Zobrazeno 1 - 10
of 100
pro vyhledávání: '"William T. Schrader"'
Publikováno v:
Photochemistry and Photobiology. 85:1225-1232
1,2,3,4-tetrahydro-2,2-dimethyl-6-(trifluoromethyl)-8-pyridono[5,6-g]quinoline (TDPQ), a selective non-steroidal ligand of the androgen receptor (AR), is a fluorescent compound we found to be photocytotoxic. We have characterized its spectral propert
Autor:
Jyun-Hung Chen, Thomas R. Caferro, Charlotte Pooley Deckhut, Lin Zhi, Christopher M. Tegley, Keith B. Marschke, Anthony W. Thompson, James P. Edwards, E. Adam Kallel, Marquis L. Cummings, Francisco J. López, William T. Schrader, Robert I. Higuchi, Mark E. Adams, Donald S. Karanewsky
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:5442-5446
A series of androgen receptor modulators based on 8H-[1,4]oxazino[2,3-f]quinolin-8-ones was synthesized and evaluated in an androgen receptor transcriptional activation assay. The most potent analogues from the series exhibited single-digit nanomolar
Autor:
Francisco J. López, William T. Schrader, and Andrés Negro-Vilar, Keith B. Marschke, Neelakandha S. Mani, Lin Zhi, Arjan van Oeveren, Mehrnouch Motamedi
Publikováno v:
Journal of Medicinal Chemistry. 49:6143-6146
The androgen receptor is a member of the extended family of nuclear receptors and is widely distributed throughout the body. Androgen therapy is used to compensate for low levels of the natural hormones testosterone (T) and dihydrotestosterone and co
Autor:
William T. Schrader
Publikováno v:
Experimental Biology and Medicine. 228:1261-1265
Holding a Ph.D. or other doctoral degree in the biological sciences used to allow for only one main career path. Faculty positions at either research-intensive universities or at predominantly teaching institutions defined the career path very well.
Autor:
Christopher M. Tegley, Mehrnouch Motamedi, Dale E. Mais, Keith B. Marschke, Josef D. Ringgenberg, Sarah J. West, Lin Zhi, William T. Schrader, Barbara Pio, Todd K. Jones, James P. Edwards
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 13:2075-2078
A series of 1,2-dihydrochromeno[3,4-f]quinoline derivatives was synthesized and tested in biological assays to evaluate the nonsteroidal progesterone receptor modulator pharmacophore (4) as antiprogestins. A number of potent analogues were identified
Autor:
Pooley Charlotte L F, Marco M. Gottardis, West Sarah J, Charles Pathirana, Ming-Wei Wang, Lin Zhi, Todd K. Jones, William T. Schrader, James P. Edwards, Christopher M. Tegley
Publikováno v:
Journal of Medicinal Chemistry. 41:2779-2785
Two potent nonsteroidal progestins from the 5-aryl-1,2-dihydro-5H-chromeno[3,4-f]quinoline class (LG120746 and LG120747) were selected for scale-up, resolution, and biological evaluation of the purified enantiomers. For each quinoline, the levorotato
Autor:
Scott A. Ochsner, Chris M. Watkins, Edward S. Chen, David L. Steffen, Boris Risek, Irina U. Agoulnik, Nancy L. Weigel, William T. Schrader, Neil J. McKenna
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::db4df90e0660df0dda9b580ac6635abd
https://doi.org/10.1210/endo-meetings.2010.part3.p2.p3-65
https://doi.org/10.1210/endo-meetings.2010.part3.p2.p3-65
Autor:
Elisabetta Vegeto, William T. Schrader, Ming-Jer Tsai, G. F. Allan, Donald P. McDonnell, Bert W. O'Malley
Publikováno v:
Cell. 69:703-713
The human progesterone receptor form B (hPR-B) was expressed in Saccharomyces cerevisiae together with a specific reporter plasmid. To understand the mechanism underlying antagonist ligand activity, libraries of hormone binding domain (HBD)-mutated h
Publikováno v:
Science. 250:1740-1743
The progesterone receptor (PR) in the chicken oviduct is a phosphoprotein that regulates gene transcription in the presence of progesterone. Treatment with progesterone in vivo stimulates phosphorylation of the progesterone receptor. With transient t
Dimerization of the Chicken Progesterone Receptorin VitroCan Occur in the Absence of Hormone and DNA
Publikováno v:
Molecular Endocrinology. 4:1782-1790
We have analyzed the dimerization of two forms of the chicken progesterone receptor (cPRA and cPRB) by nondenaturing gradient gel electrophoresis and chemical cross-linking with dimethylpimelimidate (DMP). We demonstrate by these two methods that the