Zobrazeno 1 - 10
of 27
pro vyhledávání: '"William T. Ralvenius"'
Autor:
William T. Ralvenius, Elena Neumann, Martina Pagani, Mario A. Acuña, Hendrik Wildner, Dietmar Benke, Nina Fischer, Ana Rostaher, Simon Schwager, Michael Detmar, Katrin Frauenknecht, Adriano Aguzzi, Jed Lee Hubbs, Uwe Rudolph, Claude Favrot, Hanns Ulrich Zeilhofer
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
Chronic itch affects about 10% of the general population, however current treatments are largely ineffective. Here, the authors show that targeting of inhibitory α2 and α3GABAA receptors reduces itch in mice and in a canine model, suggesting this a
Externí odkaz:
https://doaj.org/article/8993328b421e431ca678a24d0b1b96fb
Autor:
Nader Morshed, William T Ralvenius, Alexi Nott, L Ashley Watson, Felicia H Rodriguez, Leyla A Akay, Brian A Joughin, Ping‐Chieh Pao, Jay Penney, Lauren LaRocque, Diego Mastroeni, Li‐Huei Tsai, Forest M White
Publikováno v:
Molecular Systems Biology, Vol 16, Iss 12, Pp 1-27 (2020)
Abstract Alzheimer’s disease (AD) is characterized by the appearance of amyloid‐β plaques, neurofibrillary tangles, and inflammation in brain regions involved in memory. Using mass spectrometry, we have quantified the phosphoproteome of the CK
Externí odkaz:
https://doaj.org/article/7b9677d83e734c9bb4414abb7d975e62
Autor:
Joel W. Blanchard, Leyla Anne Akay, Jose Davila-Velderrain, Djuna von Maydell, Hansruedi Mathys, Shawn M. Davidson, Audrey Effenberger, Chih-Yu Chen, Kristal Maner-Smith, Ihab Hajjar, Eric A. Ortlund, Michael Bula, Emre Agbas, Ayesha Ng, Xueqiao Jiang, Martin Kahn, Cristina Blanco-Duque, Nicolas Lavoie, Liwang Liu, Ricardo Reyes, Yuan-Ta Lin, Tak Ko, Lea R’Bibo, William T. Ralvenius, David A. Bennett, Hugh P. Cam, Manolis Kellis, Li-Huei Tsai
Publikováno v:
Nature
APOE4 is the strongest genetic risk factor for Alzheimer’s disease (AD)(1–3). Yet, the effects of APOE4 on the human brain are not fully understood, limiting opportunities to develop targeted therapeutics for APOE4 and other AD risk factors(4–8
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df54e657d5fe7daad7baaff25c0f9d13
https://europepmc.org/articles/PMC9870060/
https://europepmc.org/articles/PMC9870060/
Autor:
Jay Penney, William T Ralvenius, Anjanet Loon, Oyku Cerit, Vishnu Dileep, Blerta Milo, Hannah Woolf, Li-Huei Tsai
Genetic findings have highlighted key roles for microglia in the pathology of neurodegenerative conditions such as Alzheimer’s disease (AD). Distinct mutations in the microglial protein TREM2 (triggering receptor expressed on myeloid cells 2) are a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::404954aebcdc7e3badeb5896e5f148fa
https://doi.org/10.1101/2022.10.05.511003
https://doi.org/10.1101/2022.10.05.511003
Publikováno v:
Alzheimer's & Dementia. 17
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9ec5c8d11a2f482892c4983fb38097af
https://doi.org/10.1002/alz.052667
https://doi.org/10.1002/alz.052667
Publikováno v:
Neuropharmacology. 143:71-78
Benzodiazepines (BDZ), which potentiate the action of GABA at four subtypes of GABA receptors (α1, α2, α3, and α5GABARs), are highly effective against anxiety disorders, but also cause severe side effects greatly limiting their clinical applicati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::70478f3a8e287a4662357b8ff623ad46
https://doi.org/10.1016/j.neuropharm.2018.09.026
https://doi.org/10.1016/j.neuropharm.2018.09.026
Autor:
Leyla Anne Akay, Susan Lindquist, Agnese Graziosi, Sebastian Boland, William T. Ralvenius, Valeriya Baru, Aleksandra Alicja Arczewska, Nora Kory, Julia Maeve Bonner, Elana Lockshin, Grzegorz Sienski, Caroline A. Lewis, Priyanka Narayan, Blerta Milo, Manolis Kellis, Liang He, David M. Sabatini, Li-Huei Tsai
Publikováno v:
Sci Transl Med
PMC
PMC
Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works The E4 allele of the apolipoprotein E gene (APOE) has been established as a geneti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a4318185a6e20804c536d843839fba1
http://hdl.handle.net/11585/854127
http://hdl.handle.net/11585/854127
Autor:
Leyla Anne Akay, Fatema Abdurrob, Li-Huei Tsai, Maggie Chen, Wen-Chin Huang, Jay Penney, Lorena Pantano Rubino, William T. Ralvenius, Zhuyu Peng, Xiao Chen, Hugh P. Cam
Cyclin dependent kinase 5 (Cdk5) regulates various developmental and physiological processes in the central nervous system. Deregulation of Cdk5 activity in neurons induces severe neurodegeneration and has been implicated in Alzheimer’s disease (AD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c18e44f37dde0631c3bbcda6ca3dc03
https://doi.org/10.1101/2020.05.12.090605
https://doi.org/10.1101/2020.05.12.090605
Autor:
William T. Ralvenius, L. Ashley Watson, Jay Penney, Ping-Chieh Pao, Diego Mastroeni, Lauren LaRocque, Leyla Anne Akay, Brian A. Joughin, Forest M. White, Alexi Nott, Felicia H. Rodriguez, Li-Huei Tsai, Nader Morshed
Publikováno v:
Molecular Systems Biology, Vol 16, Iss 12, Pp n/a-n/a (2020)
Molecular Systems Biology
Molecular Systems Biology
SummaryAlzheimer’s disease (AD) is characterized by the appearance of amyloid-β plaques, neurofibrillary tangles, and inflammation in brain regions involved in memory. Using mass spectrometry, we have quantified the phosphoproteome of the CK-p25,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6232f4e01e872bbf96b9aff45f0defdd
https://doi.org/10.1101/2020.05.12.090688
https://doi.org/10.1101/2020.05.12.090688
Autor:
Laetitia, Tudeau, Mario A, Acuña, Gioele W, Albisetti, Elena, Neumann, William T, Ralvenius, Louis, Scheurer, Michael, Poe, James M, Cook, Helge C, Johannssen, Hanns Ulrich, Zeilhofer
Publikováno v:
Brain research. 1741
Diminished synaptic inhibition in the superficial spinal dorsal horn contributes to exaggerated pain responses that accompany peripheral inflammation and neuropathy. α2GABA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::84a8c122e278e081fd59b33c448ef252
https://pubmed.ncbi.nlm.nih.gov/32439345
https://pubmed.ncbi.nlm.nih.gov/32439345