Zobrazeno 1 - 10
of 101
pro vyhledávání: '"William T. O'Brien"'
Autor:
Lauren P. Giesler, William T. O'Brien, Georgia F. Symons, Sabrina Salberg, Gershon Spitz, Robb Wesselingh, Terence J. O'Brien, Richelle Mychasiuk, Sandy R. Shultz, Stuart J. McDonald
Publikováno v:
Neurotrauma Reports, Vol 5, Iss 1, Pp 74-80 (2024)
Traumatic brain injuries (TBIs) and concussions are prevalent in collision sports, and there is evidence that levels of exposure to such sports may increase the risk of neurological abnormalities. Elevated levels of fluid-based biomarkers have been o
Externí odkaz:
https://doaj.org/article/12b7caa5a7f249388a0e051cc18bdca7
Autor:
Josh Allen, Louise Pham, Simon T. Bond, William T. O’Brien, Gershon Spitz, Sandy R. Shultz, Brian G. Drew, David K. Wright, Stuart J. McDonald
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 16 (2023)
IntroductionMild traumatic brain injuries (mTBIs) are the most common form of acquired brain injury. Symptoms of mTBI are thought to be associated with a neuropathological cascade, potentially involving the dysregulation of neurometabolites, lipids,
Externí odkaz:
https://doaj.org/article/7adb297148da47d298204a3936049e59
Autor:
Stuart J. McDonald, William T. O’Brien, Georgia F. Symons, Zhibin Chen, Jesse Bain, Brendan P. Major, Daniel Costello, Glenn Yamakawa, Mujun Sun, Rhys D. Brady, Biswadev Mitra, Richelle Mychasiuk, Terence J. O’Brien, Sandy R. Shultz
Publikováno v:
Biomarker Research, Vol 9, Iss 1, Pp 1-9 (2021)
Abstract Background Biomarkers that can objectively guide the diagnosis of sports-related concussion, and consequent return-to-play decisions, are urgently needed. In this study, we aimed to determine the temporal profile and diagnostic ability of se
Externí odkaz:
https://doaj.org/article/9ecca60453b544baa22c71ff9fafd25b
Autor:
Stefan Piantella, William T. O'Brien, Matthew W. Hale, Paul Maruff, Stuart J. McDonald, Bradley J. Wright
Publikováno v:
Comprehensive Psychoneuroendocrinology, Vol 10, Iss , Pp 100131- (2022)
Jockeys work in high-risk environments that rely heavily on attention- and decision-making to perform well and safely. Workplace stress literature has often overlooked the impact of stress on cognition, and designs that include physiological measures
Externí odkaz:
https://doaj.org/article/fff6b85beabc4568af9fd19bf2c099bf
Autor:
William T. O’Brien, Louise Pham, Georgia F. Symons, Mastura Monif, Sandy R. Shultz, Stuart J. McDonald
Publikováno v:
Journal of Neuroinflammation, Vol 17, Iss 1, Pp 1-12 (2020)
Abstract There is a great clinical need to identify the underlying mechanisms, as well as related biomarkers, and treatment targets, for traumatic brain injury (TBI). Neuroinflammation is a central pathophysiological feature of TBI. NLRP3 inflammasom
Externí odkaz:
https://doaj.org/article/a1bb0c6461bd448c8601bfbb5729f59a
Autor:
Lucy Vivash, Charles B. Malpas, Christian Meletis, Meghan Gollant, Dhamidhu Eratne, Qiao‐Xin Li, Stuart McDonald, William T. O'Brien, Amy Brodtmann, David Darby, Christopher Kyndt, Mark Walterfang, Christopher M. Hovens, Dennis Velakoulis, Terence J. O'Brien
Publikováno v:
Alzheimer’s & Dementia: Translational Research & Clinical Interventions, Vol 8, Iss 1, Pp n/a-n/a (2022)
Abstract Introduction Sodium selenate increases tau dephosphorylation through protein phosphatase 2 activation. Here we report an open‐label Phase 1b study of sodium selenate as a disease‐modifying treatment for behavioral variant frontotemporal
Externí odkaz:
https://doaj.org/article/2208b7c2a982408199bac2e4e96fdce6
Autor:
Louise Pham, David K. Wright, William T. O'Brien, Jesse Bain, Cheng Huang, Mujun Sun, Pablo M. Casillas-Espinosa, Anup D. Shah, Ralf B. Schittenhelm, Christopher G. Sobey, Rhys D. Brady, Terence J. O'Brien, Richelle Mychasiuk, Sandy R. Shultz, Stuart J. McDonald
Publikováno v:
Neurobiology of Disease, Vol 148, Iss , Pp 105151- (2021)
A history of mild traumatic brain injury (mTBI) is linked to a number of chronic neurological conditions, however there is still much unknown about the underlying mechanisms. To provide new insights, this study used a clinically relevant model of rep
Externí odkaz:
https://doaj.org/article/0242553506df4e8a87f3334e2abe75b1
Autor:
Brendan P. Major, Stuart J. McDonald, William T. O'Brien, Georgia F. Symons, Meaghan Clough, Daniel Costello, Mujun Sun, Rhys D. Brady, Jesse Mccullough, Roxanne Aniceto, I-Hsuan Lin, Meng Law, Richelle Mychasiuk, Terence J. O'Brien, Denes V. Agoston, Sandy R. Shultz
Publikováno v:
Frontiers in Neurology, Vol 11 (2020)
Studies have indicated that concussive and sub-concussive brain injuries that are frequent during collision sports may lead to long-term neurological abnormalities, however there is a knowledge gap on how biological sex modifies outcomes. Blood-based
Externí odkaz:
https://doaj.org/article/50c758058b344030b048d1c9b11dba97
Autor:
Jared D. Kirkland, William T. O’Brien
Publikováno v:
Journal of Clinical and Diagnostic Research, Vol 9, Iss 8, Pp TJ01-TJ02 (2015)
Externí odkaz:
https://doaj.org/article/8d2b2724ff77423a804786f49bc1828d
Autor:
William T. O'Brien
This fully revised second edition of Top 3 Differentials in Radiology provides a comprehensive core exam review of frequently encountered imaging gamuts in all major radiological subspecialties. Author William O'Brien utilizes the widely acclaimed fo
