Výsledky vyhledávání - "William T. Noonan"

Akademický článek

Comparison of the Pharmacological Effects of Paricalcitol and Doxercalciferol on the Factors Involved in Mineral Homeostasis

Autor: J. Ruth Wu-Wong, Masaki Nakane, Gerard D. Gagne, Kristin A. Brooks, William T. Noonan

Publikováno v: International Journal of Endocrinology, Vol 2010 (2010)

Vitamin D receptor agonists (VDRAs) directly suppress parathyroid hormone (PTH) mRNA expression. Different VDRAs are known to have differential effects on serum calcium (Ca), which may also affect serum PTH levels since serum Ca regulates PTH secreti

Externí odkaz: https://doaj.org/article/664dce7350114f72b3ff59fb53a26a72

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Effect of the Multitargeted Receptor Tyrosine Kinase Inhibitor, ABT-869 [N-(4-(3-Amino-1H-indazol-4-yl)phenyl)-N′-(2-fluoro-5-methylphenyl)urea], on Blood Pressure in Conscious Rats and Mice: Reversal with Antihypertensive Agents and Effect on Tumor Growth Inhibition

Autor: Bryan F. Cox, Steven K. Davidsen, Daniel H. Albert, William T. Noonan, Deborah L. Widomski, Paul Tapang, Gary A. Gintant, Pamela H. Franklin, Ryan M. Fryer, Jason A. Segreti, Patricia N. Banfor, Kelly J. Larson

Publikováno v: Journal of Pharmacology and Experimental Therapeutics. 329:928-937

ABT-869 [N-(4-(3-amino-1H-indazol-4-yl)phenyl)-N'-(2-fluoro-5-methylphenyl)urea] is a novel multitargeted inhibitor of the vascular endothelial growth factor (VEGF) and platelet-derived growth factor (PDGF) receptor tyrosine kinase family members. AB

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::511ec23ea8a2a42e3086cda5b3ea3409
https://doi.org/10.1124/jpet.108.144816

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Differential effects of vitamin D receptor activators on aortic calcification and pulse wave velocity in uraemic rats

Autor: Glenn A. Reinhart, Masaki Nakane, Doug Dixon, Junli Ma, Antoinette L. Bolin, William T. Noonan, Kristin A. Koch

Publikováno v: Nephrology Dialysis Transplantation. 23:3824-3830

Vascular calcification is associated with an increase in cardiovascular mortality in stage 5 chronic kidney disease. To determine if vitamin D receptor activators (VDRAs) have differential effects in the pathogenesis of aortic calcification, we asses

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::498018cb7a6021e6e8716745b9576375
https://doi.org/10.1093/ndt/gfn375

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Role of Phosphorus and Vitamin D Analogs in the Pathogenesis of Vascular Calcification

Autor: Glenn A. Reinhart, Doug Dixon, J. Ruth Wu-Wong, Junli Ma, Masaki Nakane, William T. Noonan, Steve Postl, Antoinette L. Bolin, Sherry J. Morgan, Kristin A. Koch

Publikováno v: Journal of Pharmacology and Experimental Therapeutics. 318:90-98

Vascular calcification is a mortality risk factor for stage 5 chronic kidney disease patients. We investigated the role of phosphorus and vitamin D analogs in the pathogenesis of vascular calcification using in vivo, ex vivo, and in vitro models. Our

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a44d860e6211c4518063ffc934d07ba3
https://doi.org/10.1124/jpet.106.101261

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Altered Renal Hemodynamics in Mice Overexpressing the Parathyroid Hormone (PTH)/PTH-Related Peptide Type 1 Receptor in Smooth Muscle

Autor: John N. Lorenz, Jin Qian, William D. Stuart, Thomas L. Clemens, William T. Noonan

Publikováno v: Endocrinology. 144:4931-4938

PTH-related protein (PTHrP) is an autocrine/paracrine peptide expressed in renal tubules and vasculature and may play an important role in regulating overall renal function. To evaluate the potential role of endogenous PTHrP in the control of renal h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd953062dd65b8ccb8210b0495b69958
https://doi.org/10.1210/en.2003-0351

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The Role of Nitric Oxide in Saline‐Induced Natriuresis and Diuresis in Rats

Autor: Robert O. Banks, William T. Noonan

Publikováno v: Proceedings of the Society for Experimental Biology and Medicine. 221:376-381

This study was designed to determine to what extent nitric oxide (NO) mediates the natriuretic and diuretic responses to acute isotonic saline (0.9 gram % NaCl) volume expansion (SVE, 0.5 ml min-1 kg-1). Studies were performed on 49 pentobarbital ane

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef63cc19517b8c1552c9cfe21a8ab058
https://doi.org/10.1046/j.1525-1373.1999.d01-95.x

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Vitamin D Receptor Activation Mitigates the Impact of Uremia on Endothelial Function in the 5/6 Nephrectomized Rats

Autor: Masaki Nakane, Bryan F. Cox, James S. Polakowski, William T. Noonan, J. Ruth Wu-Wong, Kristin A. Brooks, Jason A. Segreti

Publikováno v: International Journal of Endocrinology, Vol 2010 (2010)
International Journal of Endocrinology

Endothelial dysfunction increases cardiovascular disease risk in chronic kidney disease (CKD). This study investigates whether VDR activation affects endothelial function in CKD. The 5/6 nephrectomized (NX) rats with experimental chronic renal insuff

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5256a45f5f2594ce9597144bfaf6c059

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Comparison of the pharmacological effects of paricalcitol and doxercalciferol on the factors involved in mineral homeostasis

Autor: Masaki Nakane, Gerard D. Gagne, William T. Noonan, Kristin A. Brooks, J. Ruth Wu-Wong

Publikováno v: International Journal of Endocrinology
International Journal of Endocrinology, Vol 2010 (2010)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::867b2a9c7b7f15ef5320dcc4ff2f949d
https://pubmed.ncbi.nlm.nih.gov/20204178

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Development of late-stage diabetic nephropathy in OVE26 diabetic mice

Autor: Susan Coventry, Edward C. Carlson, Naira Metreveli, Shirong Zheng, Paul N. Epstein, William T. Noonan, Patricia M. Kralik

Publikováno v: Diabetes. 53(12)

OVE26 mice are a transgenic model of severe early-onset type 1 diabetes. These mice develop diabetes within the first weeks of life and can survive well over a year with no insulin treatment, and they maintain near normal body weight. To determine wh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::660a1415e16982e10b72f7beb26cdd9d
https://pubmed.ncbi.nlm.nih.gov/15561957

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Blood pressure maintenance in NHE3-deficient mice with transgenic expression of NHE3 in small intestine

Autor: Patrick J. Schultheis, Alison L. Woo, Vikram Prasad, Gary E. Shull, William T. Noonan, John N. Lorenz, Michelle L. Nieman

Publikováno v: American journal of physiology. Regulatory, integrative and comparative physiology. 288(3)

NHE3 Na+/H+ exchanger knockout ( Nhe3−/−) mice have severe absorptive deficits in the kidney proximal tubule and intestinal tract. The resulting hypovolemia has confounded efforts to carefully evaluate the specific effects of NHE3 deficiency on k

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bf357ba3ac943d2bc33eb5c4ef2acd9
https://pubmed.ncbi.nlm.nih.gov/15550620

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