Zobrazeno 1 - 10
of 330
pro vyhledávání: '"William T. Curry"'
Autor:
Gust Vandecandelaere, Rishab Ramapriyan, Matthew Gaffey, Leland Geoffrey Richardson, Samuel Jeffrey Steuart, Masih Tazhibi, Adrian Kalaw, Eric P. Grewal, Jing Sun, William T. Curry, Bryan D. Choi
Publikováno v:
Cells, Vol 13, Iss 17, p 1480 (2024)
Immunotherapy represents a transformative shift in cancer treatment. Among myriad immune-based approaches, chimeric antigen receptor (CAR) T-cell therapy has shown promising results in treating hematological malignancies. Despite aggressive treatment
Externí odkaz:
https://doaj.org/article/868cd5c799464249a0cfb3e80f9d4e04
Autor:
Priscilla K. Brastianos, Albert E. Kim, Anita Giobbie-Hurder, Eudocia Quant Lee, Nancy Wang, April F. Eichler, Ugonma Chukwueke, Deborah A. Forst, Isabel C. Arrillaga-Romany, Jorg Dietrich, Zachary Corbin, Jennifer Moliterno, Joachim Baehring, Michael White, Kevin W. Lou, Juliana Larson, Magali A. de Sauvage, Kathryn Evancic, Joana Mora, Naema Nayyar, Jay Loeffler, Kevin Oh, Helen A. Shih, William T. Curry, Daniel P. Cahill, Fred G. Barker, Elizabeth R. Gerstner, Sandro Santagata
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-7 (2022)
Abstract High-grade meningiomas are associated with neuro-cognitive morbidity and have limited treatments. High-grade meningiomas harbor an immunosuppressive tumor microenvironment (TME) and programmed death-ligand 1 (PD-L1) expression may contribute
Externí odkaz:
https://doaj.org/article/151a61114ef3419098315fb6862b5008
Autor:
Rishab Ramapriyan, Jing Sun, Annabel Curry, Leland G. Richardson, Tarun Ramesh, Matthew A. Gaffey, Patrick C. Gedeon, Elizabeth R. Gerstner, William T. Curry, Bryan D. Choi
Publikováno v:
Antibodies, Vol 12, Iss 4, p 74 (2023)
This review explores the evolving landscape of antibody-based therapies in neuro-oncology, in particular, immune checkpoint inhibitors and immunomodulatory antibodies. We discuss their mechanisms of action, blood-brain barrier (BBB) penetration, and
Externí odkaz:
https://doaj.org/article/5ff1171fc4b74dadbda7953a870d9548
Autor:
Yiqiao Song, Ina Ly, Qiuyun Fan, Aapo Nummenmaa, Maria Martinez-Lage, William T. Curry, Jorg Dietrich, Deborah A. Forst, Bruce R. Rosen, Susie Y. Huang, Elizabeth R. Gerstner
Publikováno v:
Frontiers in Physics, Vol 10 (2022)
Diffusion MRI is widely used for the clinical examination of a variety of diseases of the nervous system. However, clinical MRI scanners are mostly capable of magnetic field gradients in the range of 20–80 mT/m and are thus limited in the detection
Externí odkaz:
https://doaj.org/article/a31556a2d88849fdabb89d633c1ebd5e
Autor:
Bryan D. Choi, Xiaoling Yu, Ana P. Castano, Henia Darr, Daniel B. Henderson, Amanda A. Bouffard, Rebecca C. Larson, Irene Scarfò, Stefanie R. Bailey, Genevieve M. Gerhard, Matthew J. Frigault, Mark B. Leick, Andrea Schmidts, Jason G. Sagert, William T. Curry, Bob S. Carter, Marcela V. Maus
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-8 (2019)
Abstract Despite remarkable success in the treatment of hematological malignancies, CAR T-cell therapies for solid tumors have floundered, in large part due to local immune suppression and the effects of prolonged stimulation leading to T-cell dysfun
Externí odkaz:
https://doaj.org/article/987e2dc848b84c4ebabd4c5eacf43cbb
Autor:
Grishma Pawar, Neha N. Parayath, Aditya A. Sharma, Carlos Coito, Olga Khorkova, Jane Hsiao, William T. Curry, Mansoor M. Amiji, Benjamin S. Bleier
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
The most significant obstacle in the treatment of neurological disorders is the blood-brain barrier (BBB), which prevents 98% of all potential neuropharmaceuticals from reaching the central nervous system (CNS). Brain derived neurotrophic factor (BDN
Externí odkaz:
https://doaj.org/article/9b947b7cd50b4beeabc74e2eb9f6ea57
Autor:
Leland G. Richardson, Linda T. Nieman, Anat O. Stemmer-Rachamimov, Xijin S. Zheng, Khalifa Stafford, Hiroaki Nagashima, Julie J. Miller, Juri Kiyokawa, David T. Ting, Hiroaki Wakimoto, Daniel P. Cahill, Bryan D. Choi, William T. Curry
Publikováno v:
OncoImmunology, Vol 9, Iss 1 (2020)
The metabolic gene isocitrate dehydrogenase 1 (IDH1) is commonly mutated in lower grade glioma (LGG) and secondary glioblastoma (GBM). Regulatory T cells (Tregs) play a significant role in the suppression of antitumor immunity in human glioma. Given
Externí odkaz:
https://doaj.org/article/881a93cea13a4640b79c9f16c7672038
Autor:
Daniel K. Lee, Evelina Fedorenko, Mirela V. Simon, William T. Curry, Brian V. Nahed, Dan P. Cahill, Ziv M. Williams
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Functional morphemes allow us to express details about objects, events, and their relationships. Here, authors show that inhibiting a small cortical area within left posterior superior temporal lobe selectively impairs the ability to produce function
Externí odkaz:
https://doaj.org/article/0de41e3b2c9b4bb2b113ea090f0f4f4d
Publikováno v:
OncoImmunology, Vol 8, Iss 5 (2019)
Single-agent immunotherapy, including with immune checkpoint inhibition with anti-PD-1 antibody, has not extended survival in patients with malignant glioma. However, PD-1 inhibition may still play a role in combination immunotherapy with multiple ag
Externí odkaz:
https://doaj.org/article/15fce58dd49a4163abf65983b02d66b7
Publikováno v:
Journal of Neurological Surgery Reports, Vol 77, Iss 04, Pp e151-e155 (2016)
Abstract Objectives While bacterial meningitis is a concerning complication after endoscopic skull base surgery, the diagnosis can be made without consideration for aseptic meningitis. This article aims to (1) present a patient with recurrent crani
Externí odkaz:
https://doaj.org/article/f744a590878846ae94feec09c7daff39