Zobrazeno 1 - 10 of 17 pro vyhledávání: '"William T. Comer"'
1
NGP 555, a γ-secretase modulator, shows a beneficial shift in the ratio of amyloid biomarkers in human cerebrospinal fluid at safe doses
Autor: Maria Z. Kounnas, William T. Comer, Joachim Herz, Murat S. Durakoglugil
Publikováno v: Alzheimer's & Dementia : Translational Research & Clinical Interventions
Introduction Currently, there is no cure for Alzheimer's disease (AD), and it is widely accepted that AD is a complex disease with multiple approaches necessary to prevent and treat the disease. Methods Using amyloid biomarkers in human cerebrospinal
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1dd8878c6995f90b648813cfe7dfe68d
https://pubmed.ncbi.nlm.nih.gov/31921961
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2
NGP 555, a γ-secretase modulator, lowers the amyloid biomarker, Aβ42, in cerebrospinal fluid while preventing Alzheimer's disease cognitive decline in rodents
Autor: Courtney Lane-Donovan, Joachim Herz, Dan W. Nowakowski, William T. Comer, Maria Z. Kounnas
Publikováno v: Alzheimer's & Dementia: Translational Research & Clinical Interventions. 3:65-73
Introduction Alzheimer's disease (AD) is defined by the progressive accumulation of amyloid plaques and neurofibrillary tangles in the brain which precedes cognitive decline by years. Methods Using amyloid biomarkers, chemical modeling, mouse behavio
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c9e40868f457cb28458d24398096ef9
https://doi.org/10.1016/j.trci.2016.09.003
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3
NGP 555, a γ-Secretase Modulator, Lowers the Amyloid Biomarker, Aβ
Autor: Maria Z, Kounnas, Courtney, Lane-Donovan, Dan W, Nowakowski, Joachim, Herz, William T, Comer
Publikováno v: Alzheimer's & Dementia : Translational Research & Clinical Interventions
Introduction Alzheimer's disease (AD) is defined by the progressive accumulation of amyloid plaques and neurofibrillary tangles in the brain which precedes cognitive decline by years. Methods Using amyloid biomarkers, chemical modeling, mouse behavio
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::78e6ccef25075f42dbff3d23eaf3563d
https://pubmed.ncbi.nlm.nih.gov/28497107
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6
Adrenergic sulfonanilides. 4. Centrally active .beta.-adrenergic agonists
Autor: L. E. Allen, D. L. Temple, H. C. Ferguson, William T. Comer
Publikováno v: Journal of Medicinal Chemistry. 19:626-633
The central nervous system (CNS) activities of a number of soterenol analogs have been investigated, and several of these compounds possessed potent morphine antagonistic and anorexiant properties. The CNS activity of these compounds was enhanced by
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b9b821e7737cf360932e49cbe1a3168
https://doi.org/10.1021/jm00227a010
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7
Synthesis and rearrangements of 2,3,4,5-tetrahydro-3-benzazocin-6(1H)ones
Autor: Stanley J. Dykstra, Charles M. Combs, John D. Call, William T. Comer, W. Lesley Matier
Publikováno v: Journal of Heterocyclic Chemistry. 10:519-525
The preparation of 3-benzenesulfonyl- and 3-benzoyl-2,3,4,5-tetrahydro-3-benzazoein-6(1H)-ones by intramolecular acylation is described. Acid catalyzed rearrangements of these 3-benzazocin-6-ones occurs by 3,4-bond cleavage, which is followed by intr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::95e6ca37fd852d132b36d1b2fe61be00
https://doi.org/10.1002/jhet.5570100417
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