Zobrazeno 1 - 10
of 45
pro vyhledávání: '"William T. Bradner"'
Autor:
Irwin H. Krakoff, Karen Daugherty, Martin N. Raber, Dah Hsi Ho, William T. Bradner, Richard Pazdur
Publikováno v:
Investigational New Drugs. 9:377-382
FK973 is a novel, substituted dihydrobenzoxazine structurally similar to mitomycin. FK973 lacks cross-resistance with mitomycin, doxorubicin, and vincristine in murine tumor models. A phase I study of FK973 was initiated using a 30-minute infusion re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::939380b04063d80d600f932664af0315
https://doi.org/10.1007/bf00183587
https://doi.org/10.1007/bf00183587
Autor:
Dale A. Stringfellow, Hideo Kamei, John E. Schurig, Yuji Nishiyama, William C. Rose, William T. Bradner
Publikováno v:
Investigational new drugs. 8(1)
BMY-28175 is a novel antitumor antibiotic produced in fermentation by Actinomadura verrucosospora. The cytotoxic effects of BMY-28175 were determined using murine and human tumor cell lines in vitro. Following 72 hour exposure, the drug had IC50 valu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::276f5334f9c3a64bfafc6d3c923650df
https://pubmed.ncbi.nlm.nih.gov/2345072
https://pubmed.ncbi.nlm.nih.gov/2345072
Publikováno v:
Investigational new drugs. 8
BMY-25067, N-7[2-(4-nitrophenyldithio)-ethyl] mitomycin C was selected from a number of disulfide derivatives of the highly active compound RR150, N-7(thioethyl) mitomycin C for further study. BMY-25067 had tumor inhibitory effects equivalent to mito
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3166c8d2c8b82ccd25a49275d722ae0
https://pubmed.ncbi.nlm.nih.gov/2380013
https://pubmed.ncbi.nlm.nih.gov/2380013
Publikováno v:
The Journal of antibiotics. 43(1)
It intrigued us to see what effect two heteroatoms in a cyclic acetal form would have on antitumor activity. In this communication we report the synthesis of such derivatives and their rather remarkable antitumor activity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9592f4e7747cb2fb83db99faa0fb2325
https://pubmed.ncbi.nlm.nih.gov/2307625
https://pubmed.ncbi.nlm.nih.gov/2307625
Publikováno v:
Investigational New Drugs. 7:173-178
BMY-28090 is a novel actinomycete fermentation derived antitumor agent. The cytotoxic effect of BMY-28090 was evaluated in two murine and eight human tumor cell lines in vitro. Following 72-hour exposures, BMY-28090 was cytotoxic for all of these cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::487453a78764ac2905a08692996e302c
https://doi.org/10.1007/bf00170854
https://doi.org/10.1007/bf00170854
Autor:
Mahesh Patel, Bush James A, C. A. Claridge, Ann C. Horan, James A. Matson, Jeffery Titus, William T. Bradner, Terrence W. Doyle
Publikováno v:
The Journal of Antibiotics. 42:1547-1555
Compounds AT2433-A1 (A1), AT2433-A2 (A2), AT2433-B1 (B1), and AT2433-B2 (B2) were isolated from the cultured broth of Actinomadura melliaura sp. nov. (SCC 1655). Structurally these materials are closely related to rebeccamycin (1), an indolocarbazole
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::824e7d036fceff35a8dc1a5d74f7d818
https://doi.org/10.7164/antibiotics.42.1547
https://doi.org/10.7164/antibiotics.42.1547
Publikováno v:
Journal of Medicinal Chemistry. 32:703-708
On the basis of qualitative structure-activity relationships developed in the preceding article, a series of 32 new mitomycin A analogues were prepared and tested in antitumor screens. Seven of them gave greater prolongation of life (ILS) than mitomy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cc9fb9d4820467dc11750cd06103999
https://doi.org/10.1021/jm00123a036
https://doi.org/10.1021/jm00123a036
Autor:
Robert W. Myllymaki, Schreiber Richard H, Alonzo B. Coon, Albert L. Vulcano, William T. Bradner, Donald E. Nettleton, Bush James A, F. A. O'herron, John E. Moseley
Publikováno v:
The Journal of Antibiotics. 30:525-529
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50cb0a2eb4d96edc3881d434e81629bd
https://doi.org/10.7164/antibiotics.30.525
https://doi.org/10.7164/antibiotics.30.525
Autor:
David M. Balitz, Alonzo B. Coon, David L. Johnson, William T. Bradner, Terrence W. Doyle, Robert W. Myllymaki, John E. Moseley, F. A. O'herron, Schreiber Richard H, Donald E. Nettleton
Publikováno v:
Journal of Natural Products. 43:242-258
Six anthracycline antitumor agents, marcellomycin, musettamycin, rudolphomycin, alcindoromycin, collinemycin, and mimimycin, have now been isolated from bohemic acid complex. This has been achieved by classical column chromatography with Sephadex LH-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7824fa8db1fd37f76eee8030f70b039
https://doi.org/10.1021/np50008a003
https://doi.org/10.1021/np50008a003