Zobrazeno 1 - 10
of 228
pro vyhledávání: '"William T Gerthoffer"'
Autor:
Steve M. Cordina, Shant Afarian, William T. Gerthoffer, Anthony Martino, Russell Wilson, Dean K. Naritoku
Publikováno v:
Frontiers in Neurology, Vol 11 (2020)
Background and Purpose: The growth and eventual rupture of intracranial aneurysms may be due to an underlying inflammatory process as evidenced by pathological examination of aneurysm walls. We hypothesize that unruptured aneurysms have an increased
Externí odkaz:
https://doaj.org/article/22d9771a213740f8a12514524a9d0f6e
Autor:
Andrew P. Ferretti, Majed Matar, Jeff Sparks, Sabrina Ramelli, William T. Gerthoffer, Lydia L. Sandy, Jason G. Fewell, Jared M. McLendon, Brian S. Comer, Robert A. Barrington
Publikováno v:
Molecular Therapy. Nucleic Acids
To address the problem of poor asthma control due to drug resistance, an antisense oligonucleotide complementary to mmu-miR-145a-5p (antimiR-145) was tested in a house dust mite mouse model of mild/moderate asthma. miR-145 was targeted to reduce infl
Autor:
Nadia Maarouf, Ayinuer Adijiang, Jingti Deng, Yong Xiang Chen, Zarah Batulan, Annegret Ulke-Lemée, Sonya Bharadwa, Vipul Shrivastava, William T. Gerthoffer, Jonathan L.E. Dean, Chunhua Shi, F. Daniel Ramirez, Alexandria Hellmich, Catherine Diao, Brenig Gwilym, Angie A. Hu, Jingwen Liu, Matthew Rosin, Edward R. O'Brien, Christopher Malozzi
Publikováno v:
Arterioscler Thromb Vasc Biol
Objective: Elevated HSP27 (heat shock protein 27) levels predict relative freedom from cardiovascular events. Over-expression or twice daily subcutaneous injections of human HSP27 in ApoE −/− mice reduces blood and plaque cholesterol levels, as w
Autor:
Sabrina Ramelli, William T. Gerthoffer
Publikováno v:
Advances in Experimental Medicine and Biology ISBN: 9783030630454
Asthma is a chronic inflammatory obstructive lung disease that is stratified into endotypes. Th2 high asthma is due to an imbalance of Th1/Th2 signaling leading to abnormally high levels of Th2 cytokines, IL-4, IL-5, and IL-13 and in some cases a red
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c7a81e42857ee7c7e018e68fac83ab50
https://doi.org/10.1007/978-3-030-63046-1_6
https://doi.org/10.1007/978-3-030-63046-1_6
Autor:
William T. Gerthoffer
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 21, Iss 9222, p 9222 (2020)
International Journal of Molecular Sciences, Vol 21, Iss 9222, p 9222 (2020)
Arterial wall remodeling underlies increased pulmonary vascular resistance and right heart failure in pulmonary arterial hypertension (PAH). None of the established vasodilator drug therapies for PAH prevents or reverse established arterial wall thic
Autor:
William T. Gerthoffer, Sonya Bharadwa, Yong-Xiang Chen, Angie Hu, Chunhua Shi, Vipul Shrivastava, Jingwen Liu, Annegret Ulke-Lemée, Edward R. O'Brien, Ayinuer Adijiang, Brenig Llwyd Gwilym, Zarah Batulan, Matthew Rosin, Jingti Deng, Alexandria Hellmich, F. Daniel Ramirez, Christopher Malozzi, Jonathan L.E. Dean, Catherine Diao, Nadia Maarouf
Elevated Heat Shock Protein 27 levels predict relative freedom from cardiovascular events. In ApoE-/- mice HSP27 over-expression or twice daily subcutaneous injections reduce blood and plaque cholesterol levels, inflammation and atherogenesis. While
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a8be053f6419227269d8dc11970508f6
https://doi.org/10.1101/2020.05.21.102350
https://doi.org/10.1101/2020.05.21.102350
Autor:
Viktor E. Eysselein, Fabio Cominelli, W. J. Snape, Yining Xie, William T. Gerthoffer, S. Narasimha Reddy
Publikováno v:
Effects of Immune Cells and Inflammation on Smooth Muscle and Enteric Nerves
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c2a0888af0c9ab9df4a44e8cb7d9d9cb
https://doi.org/10.1201/9780367813024-7
https://doi.org/10.1201/9780367813024-7
Autor:
Gang Liu, Marina Mazur, Namasivayam Ambalavanan, William T. Gerthoffer, Peng Li, William T. Harris, Tomasz Szul, Farruk M. Lutful Kabir, Brian Halloran, George M. Solomon, Steven M. Rowe, Charitharth Vivek Lal
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 197:632-643
Rationale: MicroRNAs (miRNAs) destabilize mRNA transcripts and inhibit protein translation. miR-145 is of particular interest in cystic fibrosis (CF) as it has a direct binding site in the 3′-untranslated region of CFTR (cystic fibrosis transmembra
Autor:
Naresh Singh Redhu, Ali Saleh, Lianyu Shan, William T Gerthoffer, Sam K Kung, Andrew J Halayko, Bouchaib Lamkhioued, Abdelilah S Gounni
Publikováno v:
PLoS ONE, Vol 4, Iss 7, p e6153 (2009)
BACKGROUND:The high affinity IgE receptor (FcepsilonRI) is a crucial structure for IgE-mediated allergic reactions. We have previously demonstrated that human airway smooth muscle (ASM) cells express the tetrameric (alphabetagamma2) FcepsilonRI, and
Externí odkaz:
https://doaj.org/article/febe1ff7ccd742c3a3f4595c86f6a9ca
Autor:
Yelitza A.R. Rodriguez, James M. Murphy, Hyun Kyung Kong, Jun-Sub Kim, Hyeonsoo Park, Chung-Sik Choi, Kyuho Jeong, William T. Gerthoffer, Ssang-Taek Lim, Su-Jeong Kim, Thomas M. Lincoln, Jung-Hyun Kim, David D. Schlaepfer, Eun-Young Erin Ahn, Joan M. Taylor, Jun-Lin Guan
Publikováno v:
Circulation research, vol 125, iss 2
Rationale: Neointimal hyperplasia is characterized by excessive accumulation of vascular smooth muscle cells (SMCs) leading to occlusive disorders, such as atherosclerosis and stenosis. Blood vessel injury increases growth factor secretion and matrix
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56eba75e31aa4d2892bd0f12f9b8713e
https://escholarship.org/uc/item/8t71z6h3
https://escholarship.org/uc/item/8t71z6h3