Zobrazeno 1 - 10
of 20
pro vyhledávání: '"William T Arthur"'
Autor:
Kazuhide Watanabe, Jacob Biesinger, Michael L Salmans, Brian S Roberts, William T Arthur, Michele Cleary, Bogi Andersen, Xiaohui Xie, Xing Dai
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e92317 (2014)
Deregulation of canonical Wnt/CTNNB1 (beta-catenin) pathway is one of the earliest events in the pathogenesis of colon cancer. Mutations in APC or CTNNB1 are highly frequent in colon cancer and cause aberrant stabilization of CTNNB1, which activates
Externí odkaz:
https://doaj.org/article/32b136c03a554fb59c79b7d4dc578fd6
Autor:
Willliam Conrad, Michael B Major, Michele A Cleary, Marc Ferrer, Brian Roberts, Shane Marine, Namjin Chung, William T Arthur, Randall T Moon, Jason D Berndt, Andy J Chien
Publikováno v:
F1000Research, Vol 2 (2013)
The inability of targeted BRAF inhibitors to produce long-lasting improvement in the clinical outcome of melanoma highlights a need to identify additional approaches to inhibit melanoma growth. Recent studies have shown that activation of the Wnt/β-
Externí odkaz:
https://doaj.org/article/ff1f05613bc44720a0cd8e4b015f5057
Autor:
Richard A Klinghoffer, Jason Frazier, James Annis, Jason D Berndt, Brian S Roberts, William T Arthur, Raul Lacson, Xiaohua Douglas Zhang, Marc Ferrer, Randall T Moon, Michele A Cleary
Publikováno v:
PLoS ONE, Vol 4, Iss 9, p e6892 (2009)
The multi-protein beta-catenin destruction complex tightly regulates beta-catenin protein levels by shuttling beta-catenin to the proteasome. Glycogen synthase kinase 3beta (GSK3beta), a key serine/threonine kinase in the destruction complex, is resp
Externí odkaz:
https://doaj.org/article/f7d54404600940718769d3f54263a1b4
Publikováno v:
The Journal of Cell Biology
The Ras-related GTPase Rap1 stimulates integrin-mediated adhesion and spreading in various mammalian cell types. Here, we demonstrate that Rap1 regulates cell spreading by localizing guanine nucleotide exchange factors (GEFs) that act via the Rho fam
Publikováno v:
Journal of Biological Chemistry. 277:42964-42972
Rho proteins cycle between an inactive, GDP-bound state and an active, GTP-bound state. Activation of these GTPases is mediated by guanine nucleotide exchange factors (GEFs), which promote GDP to GTP exchange. In this study we have characterized XPLN
Autor:
Keith Burridge, William T. Arthur
Publikováno v:
Molecular Biology of the Cell. 12:2711-2720
The binding of extracellular matrix proteins to integrins triggers rearrangements in the actin cytoskeleton by regulating the Rho family of small GTPases. The signaling events that mediate changes in the activity of Rho proteins in response to the ex
Publikováno v:
Microvascular Research. 55:260-270
Aging is accompanied by impaired angiogenesis and deficient expression of several angiogenic growth factors. To test the hypothesis that replacement of these factors would improve angiogenesis in aged animals, we cultured microvessels derived from th
Autor:
William T. Arthur, Krister Wennerberg, Marisa M. Menold, Keith Burridge, Adi D. Dubash, Rafael Garcia-Mata
Adhesion of cells to extracellular matrix proteins such as fibronectin initiates signaling cascades that affect cell morphology, migration and survival. Some of these signaling pathways involve the Rho family of GTPases, such as Cdc42, Rac1 and RhoA,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c00251947dc2e7371c3106cd8cff1a1
Autor:
Rafael, García-Mata, Krister, Wennerberg, William T, Arthur, Nicole K, Noren, Shawn M, Ellerbroek, Keith, Burridge
Publikováno v:
Methods in enzymology. 406
An assay was developed that allows the precipitation of the active pools of Rho-GEFs, Rho-GAPs, or effectors from cell or tissue lysates. This assay can be used to identify GEFs, GAPs, and effectors involved in specific cellular pathways to determine
Autor:
Shawn M. Ellerbroek, Rafael Garcia-Mata, Nicole K Noren, Keith Burridge, Krister Wennerberg, William T. Arthur
An assay was developed that allows the precipitation of the active pools of Rho‐GEFs, Rho‐GAPs, or effectors from cell or tissue lysates. This assay can be used to identify GEFs, GAPs, and effectors involved in specific cellular pathways to deter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::56708d12e8f9f21857caab1a21334941
https://doi.org/10.1016/s0076-6879(06)06031-9
https://doi.org/10.1016/s0076-6879(06)06031-9