Zobrazeno 1 - 10
of 28
pro vyhledávání: '"William T, Simonson"'
Autor:
Paul Nghiem, Jürgen C. Becker, Michele A. Cleary, Mary L. Disis, James S. Hardwick, Shigetoshi Sano, Hideki Nakajima, Shailender Bhatia, Margaret Madeleine, David M. Koelle, Aaron Seo, William T. Simonson, Kotaro Nagase, Renee Thibodeau, Shinichi Koba, David Schrama, Olga K. Afanasiev, Jayasri G. Iyer, Christoph Willmes, Andrew Tegeder, Kelly G. Paulson
Allred proportion (ranging from 0-5) and intensity (ranging from 0-3) scores for each tumor. The median score among triplicate TMA cores and reviewers was utilized. Most MCC tumors with an Allred score of 7 continued to express MHC class I in all tum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e21b37ae9a8a91c6b8254cd93dad3a6
https://doi.org/10.1158/2326-6066.22536656
https://doi.org/10.1158/2326-6066.22536656
Autor:
Paul Nghiem, Jürgen C. Becker, Michele A. Cleary, Mary L. Disis, James S. Hardwick, Shigetoshi Sano, Hideki Nakajima, Shailender Bhatia, Margaret Madeleine, David M. Koelle, Aaron Seo, William T. Simonson, Kotaro Nagase, Renee Thibodeau, Shinichi Koba, David Schrama, Olga K. Afanasiev, Jayasri G. Iyer, Christoph Willmes, Andrew Tegeder, Kelly G. Paulson
Merkel cell carcinoma (MCC) is an aggressive, polyomavirus-associated skin cancer. Robust cellular immune responses are associated with excellent outcomes in patients with MCC, but these responses are typically absent. We determined the prevalence an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::01f16f5f51fe223535e73684730546ab
https://doi.org/10.1158/2326-6066.c.6548198.v1
https://doi.org/10.1158/2326-6066.c.6548198.v1
Autor:
Deborah I. Ritter, Ata S. Moshiri, Mark H. Wener, Masaoki Kawasumi, Jayasri G. Iyer, Aaron Lisberg, Erica S. Tarabadkar, William T. Simonson, Lola Mudgistratova, C. Lewis, Chihiro Morishima, Joseph J. Carter, Kelly G. Paulson, Astrid Blom, Paul Nghiem, Denise A. Galloway, Kathleen Hutchinson, Shailender Bhatia, Mary W. Redman
Publikováno v:
Cancer. 123:1464-1474
BACKGROUND Merkel cell carcinoma (MCC) is an aggressive skin cancer with a recurrence rate of >40%. Of the 2000 MCC cases per year in the United States, most are caused by the Merkel cell polyomavirus (MCPyV). Antibodies to MCPyV oncoprotein (T-antig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ccf0947240672527e4e4f1991abee4f0
https://doi.org/10.1002/cncr.30475
https://doi.org/10.1002/cncr.30475
Autor:
Jennifer Vetrovs, William T. Simonson, Najwa Al-Bustani, Michael D. Weiss, Mark H. Wener, Leo H. Wang, Desiree A. Marshall
Publikováno v:
Journal of Clinical Neuromuscular Disease. 17:63-68
Objective To evaluate the role of paraneoplastic autoantibody testing in the diagnosis of motor neuron disease (MND). Background There have been rare case reports of paraneoplastic MND that have prompted many physicians to test for paraneoplastic aut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e587ee701c4de5f2c6bd63473d8bd90c
https://doi.org/10.1097/cnd.0000000000000080
https://doi.org/10.1097/cnd.0000000000000080
Autor:
Jayasri G. Iyer, Stephanie Pietromonaco, William T. Simonson, Kelly G. Paulson, Renee Thibodeau, Monica Sokil, Astrid Blom, Maryam M. Asgari, Miranda Schmidt, E. Margaret Warton, Paul Nghiem
Publikováno v:
American Journal of Clinical Pathology. 142:452-458
Merkel cell carcinoma (MCC) is a skin cancer with a reported incidence rate that has almost quadrupled in the past two decades in the United States1 and has an often-aggressive disease course (disease-associated mortality of 46%).2 Although recently
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b01adbc5f6ca7f284675316505a987b2
https://doi.org/10.1309/ajcpikdzm39crpnc
https://doi.org/10.1309/ajcpikdzm39crpnc
Autor:
Rachael A. Clark, David M. Koelle, Paul Nghiem, Kotaro Nagase, Olga K. Afanasiev, Astrid Blom, William T. Simonson, Natalie Vandeven
Publikováno v:
Journal of Investigative Dermatology. 133:2065-2073
Merkel cell carcinoma (MCC) is an aggressive, polyomavirus-linked skin cancer. Although CD8 lymphocyte infiltration into the tumor is strongly correlated with improved survival, these cells are absent or sparse in most MCCs. We investigated whether s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43da047abf2011f9c66ba2e75db9f0e6
https://doi.org/10.1038/jid.2013.36
https://doi.org/10.1038/jid.2013.36
Autor:
Kelly G, Paulson, Christopher W, Lewis, Mary W, Redman, William T, Simonson, Aaron, Lisberg, Deborah, Ritter, Chihiro, Morishima, Kathleen, Hutchinson, Lola, Mudgistratova, Astrid, Blom, Jayasri, Iyer, Ata S, Moshiri, Erica S, Tarabadkar, Joseph J, Carter, Shailender, Bhatia, Masaoki, Kawasumi, Denise A, Galloway, Mark H, Wener, Paul, Nghiem
Publikováno v:
Cancer. 123(8)
Merkel cell carcinoma (MCC) is an aggressive skin cancer with a recurrence rate of40%. Of the 2000 MCC cases per year in the United States, most are caused by the Merkel cell polyomavirus (MCPyV). Antibodies to MCPyV oncoprotein (T-antigens) have bee
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b7082593bf466feb1d1044a8a8adbc8a
https://pubmed.ncbi.nlm.nih.gov/27925665
https://pubmed.ncbi.nlm.nih.gov/27925665
PIPKIγ90 Negatively Regulates LFA-1–Mediated Adhesion and Activation in Antigen-Induced CD4+ T Cells
Publikováno v:
The Journal of Immunology. 185:4714-4723
T cell activation requires the formation and maintenance of stable interactions between T cells and APCs. The formation of stable T cell–APC contacts depends on the activation of the integrin LFA-1 (CD11aCD18). Several positive regulators of LFA-1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56650c2564c96e6a5e050fe50e720476
https://doi.org/10.4049/jimmunol.1001445
https://doi.org/10.4049/jimmunol.1001445
Autor:
Xiuxu Chen, Sarah A. Wernimont, Anna Huttenlocher, Amy R. Howell, Xiaohua Wang, Darren Gibson, Gurdyal S. Besra, Rachel M. Ndonye, William T. Simonson, Natacha Veerapen, Lance A. Rodenkirch, Jenny E. Gumperz, Gavin F. Painter
Publikováno v:
Blood. 112:4128-4138
Natural killer T (NKT) cells are innate-like T cells that recognize specific microbial antigens and also display autoreactivity to self-antigens. The nature of NKT-cell autoreactive activation remains poorly understood. We show here that the mitogen-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7629bba482399f90b28141441b8bd552
https://doi.org/10.1182/blood-2008-05-157529
https://doi.org/10.1182/blood-2008-05-157529
Publikováno v:
The Journal of Immunology. 177:7707-7714
The leukocyte integrin LFA-1 plays a critical role in T cell trafficking and T cell adhesion to APCs. It is known that integrin-mediated adhesion is regulated by changes in integrin ligand-binding affinity and valency through inside-out signaling. Ho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aac15bcfe4b36464b7a4f44805303fbe
https://doi.org/10.4049/jimmunol.177.11.7707
https://doi.org/10.4049/jimmunol.177.11.7707