Zobrazeno 1 - 6
of 6
pro vyhledávání: '"William Shu Ching Ngai"'
Publikováno v:
CCS Chemistry. 5:802-813
Autor:
William Shu Ching Ngai, Shaojun Yang, Xiangmei Zeng, Yanjun Liu, Feng Lin, Xin Wang, Heng Zhang, Xinyuan Fan, Peng R. Chen
Publikováno v:
Journal of the American Chemical Society. 144:5411-5417
Pyroptosis is an inflammatory cell death form triggered by protease-mediated truncation and release of the N-terminal pore-forming domain of the gasdermin (GSDM) family proteins in various cell types. We report a Bioorthogonally ACtivatable Base edit
Autor:
Huixin Luo, Wei Tang, Hongyu Liu, Xiangmei Zeng, William Shu Ching Ngai, Rui Gao, Heyun Li, Ran Li, Huangtao Zheng, Jianting Guo, Fangfei Qin, Gang Wang, Kexin Li, Xinyuan Fan, Peng Zou, Peng R. Chen
Publikováno v:
Angewandte Chemie. 134
The dynamic interactions between RNAs and proteins play crucial roles in regulating diverse cellular processes. Proteome-wide characterization of these interactions in their native cellular context remains desirable but challenging. Herein, we develo
Publikováno v:
CCS Chemistry. 1:226-236
Current antibody–drug conjugates (ADCs) suffer from low tissue penetration and significant side effects, largely due to the permanent linkage and/or premature release of cytotoxic payloads. Herein, we developed a prodrug–antibody conjugate (ProAD
Autor:
Xin Wang, William Shu Ching Ngai, Yanjun Liu, Gong Zhang, Peng Chen, Jian Lin, Heng Zhang, Xinyuan Fan, Jiaofeng Li, Jie Wang
Publikováno v:
Journal of the American Chemical Society. 141(43)
Temporal and reversible control over protein and cell conjugations holds great potential for traceless release of antibody-drug conjugates (ADCs) on tumor sites as well as on-demand altering or removal of targeting elements on cell surface. We herein
Autor:
Xinyuan Fan, Feng Lin, Gong Zhang, Jie Wang, Yun Ge, Peng Chen, Zhi Lin, William Shu Ching Ngai, Yang Yang, Jingyi Zhao, Siqi Zheng, Jie Li
Publikováno v:
Angewandte Chemie International Edition. 55:14046-14050
The inverse-electron-demand Diels-Alder (iDA) reaction has recently been repurposed as a bioorthogonal decaging reaction by accelerating the elimination process after an initial cycloaddition between trans-cyclooctene (TCO) and tetrazine (TZ). Herein