Zobrazeno 1 - 10
of 139
pro vyhledávání: '"William S. Trimble"'
Autor:
Christopher J. Stefan, William S. Trimble, Sergio Grinstein, Guillaume Drin, Karin Reinisch, Pietro De Camilli, Sarah Cohen, Alex M. Valm, Jennifer Lippincott-Schwartz, Tim P. Levine, David B. Iaea, Frederick R. Maxfield, Clare E. Futter, Emily R. Eden, Delphine Judith, Alexander R. van Vliet, Patrizia Agostinis, Sharon A. Tooze, Ayumu Sugiura, Heidi M. McBride
Publikováno v:
BMC Biology, Vol 15, Iss 1, Pp 1-24 (2017)
Abstract Discoveries spanning several decades have pointed to vital membrane lipid trafficking pathways involving both vesicular and non-vesicular carriers. But the relative contributions for distinct membrane delivery pathways in cell growth and org
Externí odkaz:
https://doaj.org/article/57743286285748dc972d7417983b6f72
Autor:
John L. Rubinstein, William S. Trimble, Samir Benlekbir, Oliva Palander, Yadu Balachandran, Richard Collins, Moshe S. Kim, Forooz Soroor
Publikováno v:
Molecular Biology of the Cell
Septins are conserved GTP-binding cytoskeletal proteins that polymerize into filaments by end-to-end joining of heterooligomeric complexes. In human cells, both hexamers and octamers exist, and crystallography studies predicted the order of the hexam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d987443e310fca1d4e100ccca02d038
https://doi.org/10.1091/mbc.e20-06-0398
https://doi.org/10.1091/mbc.e20-06-0398
Autor:
Darya Safavian, Moshe S. Kim, Hong Xie, Lu Dai, Richard F. Collins, Carol Froese, Koh-ichi Nagata, William S. Trimble
Septins are filamentous GTPases that play important, but poorly characterized roles in ciliogenesis. Here, we show that SEPTIN9 regulates RhoA signaling at the base of cilia by binding and activating the RhoA guanine nucleotide exchange factor, ARHGE
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::164d65a58e6a57d7b35b3826cb42b74e
https://doi.org/10.1101/2022.05.20.492811
https://doi.org/10.1101/2022.05.20.492811
Publikováno v:
BioEssays : news and reviews in molecular, cellular and developmental biologyREFERENCES. 44(3)
Hedgehog (Hh) signaling is a widely studied signaling pathway because of its critical roles during development and in cell homeostasis. Vertebrate canonical and non-canonical Hh signaling are typically assumed to be distinct and occur in different ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6739de733e2a6092f0bb450e9c97465
https://pubmed.ncbi.nlm.nih.gov/35001404
https://pubmed.ncbi.nlm.nih.gov/35001404
Autor:
Dante Neculai, Saskia Heybrock, Sergio Grinstein, Régis Pomès, Renate Lüllmann-Rauch, Ying Meng, Christopher Ing, Kristiina Kanerva, Paul Saftig, Michael Schwake, Joerg Heeren, Wim Annaert, William S. Trimble, Anna Liang, Xialian Weng, Elina Ikonen, Gilbert G. Privé, Richard F. Collins, Young Ah Kim, Zi-Jian Xiong
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Nature Communications
Nature Communications
The intracellular transport of cholesterol is subject to tight regulation. The structure of the lysosomal integral membrane protein type 2 (LIMP-2, also known as SCARB2) reveals a large cavity that traverses the molecule and resembles the cavity in S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41bbdbaeac257aa9248e7b354a2c063e
https://doaj.org/article/7ad18a0cfcb742e09b108e2916ba4cfd
https://doaj.org/article/7ad18a0cfcb742e09b108e2916ba4cfd
Autor:
Tara Akhshi, William S. Trimble
Publikováno v:
The Journal of Cell Biology
Hedgehog (Hh) is an essential signaling pathway for embryonic development and adulthood. Here, we show that noncanonical Hh induces the formation of primary cilia, the critical signaling hubs whose absence leads to a variety of severe disorders, via
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f81a04691423f5cae4e431e195fd3e0
https://doi.org/10.1083/jcb.202004179
https://doi.org/10.1083/jcb.202004179
Autor:
Cosmin L Pocanschi, Sepehr Ehsani, Mohadeseh Mehrabian, Holger Wille, William Reginold, William S Trimble, Hansen Wang, Adelinda Yee, Cheryl H Arrowsmith, Zoltán Bozóky, Lewis E Kay, Julie D Forman-Kay, James M Rini, Gerold Schmitt-Ulms
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e72446 (2013)
The cellular prion protein (PrP(C)) was recently observed to co-purify with members of the LIV-1 subfamily of ZIP zinc transporters (LZTs), precipitating the surprising discovery that the prion gene family descended from an ancestral LZT gene. Here,
Externí odkaz:
https://doaj.org/article/7f14ae4f541049da90c33b65e26c100e
Autor:
William S. Trimble, Oliva Palander
Publikováno v:
FASEB journal : official publication of the Federation of American Societies for Experimental BiologyREFERENCES. 34(12)
Primary cilia are critical hubs for several signaling pathways, and defects in ciliogenesis or cilia maintenance produce a range of diseases collectively known as ciliopathies. Ciliogenesis requires vesicle trafficking along a network of microtubules
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::655d28fae997791de4a0d9ef4b8757b9
https://pubmed.ncbi.nlm.nih.gov/33124112
https://pubmed.ncbi.nlm.nih.gov/33124112
Autor:
William S. Trimble, Forooz Soroor, Carol D. Froese, Maximiliano Giuliani, Adriano Vissa, Moshe S. Kim, Christopher M. Yip, Peter K. Kim
Publikováno v:
Cytoskeleton. 76:63-72
Septins are a conserved family of GTPases that associate with numerous components of the cytoskeleton and the inner leaflet of the plasma membrane. These proteins are involved in many biological processes, including cell division and membrane traffic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8635b21c6e751847e86ef0ee5bed5ea0
https://doi.org/10.1002/cm.21481
https://doi.org/10.1002/cm.21481
Publikováno v:
The Journal of Biological Chemistry
Primary cilia are hubs for several signaling pathways, and disruption in cilia function and formation leads to a range of diseases collectively known as ciliopathies. Both ciliogenesis and cilia maintenance depend on vesicle trafficking along a netwo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c6f8ae30521795c25176a8f3be080f1
https://doi.org/10.1016/j.jbc.2021.100680
https://doi.org/10.1016/j.jbc.2021.100680