Zobrazeno 1 - 10
of 26
pro vyhledávání: '"William S. Sawyer"'
Autor:
Inga Nilsson, Sheng Y. Lee, William S. Sawyer, Christopher M. Baxter Rath, Guillaume Lapointe, David A. Six
Publikováno v:
Journal of Lipid Research, Vol 61, Iss 6, Pp 870-883 (2020)
Gram-negative bacteria possess an asymmetric outer membrane (OM) composed primarily of lipopolysaccharides (LPSs) on the outer leaflet and phospholipids (PLs) on the inner leaflet. The loss of this asymmetry due to mutations in the LPS biosynthesis o
Externí odkaz:
https://doaj.org/article/27af6585350e4efba5e56966c405a8c0
Autor:
Aimee Fourie-O’Donohue, Phillip Y. Chu, Josefa dela Cruz Chuh, Robert Tchelepi, Siao Ping Tsai, John C. Tran, William S. Sawyer, Dian Su, Carl Ng, Keyang Xu, Shang-Fan Yu, Thomas H. Pillow, Jack Sadowsky, Peter S. Dragovich, Yichin Liu, Katherine R. Kozak
Publikováno v:
mAbs, Vol 12, Iss 1 (2020)
For antibody-drug conjugates to be efficacious and safe, they must be stable in circulation to carry the payload to the site of the targeted cell. Several components of a drug-conjugated antibody are known to influence stability: 1) the site of drug
Externí odkaz:
https://doaj.org/article/e46e20ec184a4063ba55b87d5b9f2d28
Autor:
Mina Mostafavi, Lisha Wang, Lili Xie, Kenneth T. Takeoka, Daryl L. Richie, Fergal Casey, Alexey Ruzin, William S. Sawyer, Christopher M. Rath, Jun-Rong Wei, Charles R. Dean
Publikováno v:
mSphere, Vol 3, Iss 5 (2018)
ABSTRACT Tight coordination of inner and outer membrane biosynthesis is very important in Gram-negative bacteria. Biosynthesis of the lipid A moiety of lipopolysaccharide, which comprises the outer leaflet of the outer membrane has garnered interest
Externí odkaz:
https://doaj.org/article/1e5ff2b427e345449955f5246fb5ce69
Autor:
Jun-Rong Wei, Daryl L. Richie, Mina Mostafavi, Louis E. Metzger, Christopher M. Rath, William S. Sawyer, Kenneth T. Takeoka, Charles R. Dean
Publikováno v:
mSphere, Vol 2, Iss 4 (2017)
ABSTRACT Acinetobacter baumannii ATCC 19606 can grow without lipid A, the major component of lipooligosaccharide. However, we previously reported that depletion of LpxH (the fourth enzyme in the lipid A biosynthetic pathway) prevented growth of this
Externí odkaz:
https://doaj.org/article/e288e2e6824e4e1d854b8e90cdc75dee
Autor:
Cong, Wu, Ryan, Cook, Ping, Wu, Neha, Srikumar, Elin, Chee, William S, Sawyer, Hua, Wang, Meredith, Hazen, Isidro, Hotzel, Elsa-Noah, N'Diaye, Ning, Ding, Yichin, Liu, John C, Tran, Zhengmao, Ye
Publikováno v:
Analytical and Bioanalytical Chemistry. 414:6601-6610
Proteases are critical proteins involved in cleaving substrates that may impact biological pathways, cellular processes, or disease progression. In the biopharmaceutical industry, modulating the levels of protease activity is an important strategy fo
Autor:
Christopher M. Rath, David A. Six, Inga Nilsson, William S. Sawyer, Guillaume Lapointe, Sheng Y. Lee
Publikováno v:
J Lipid Res
Journal of Lipid Research, Vol 61, Iss 6, Pp 870-883 (2020)
Journal of Lipid Research, Vol 61, Iss 6, Pp 870-883 (2020)
Gram-negative bacteria possess an asymmetric outer membrane (OM) composed primarily of lipopolysaccharides (LPSs) on the outer leaflet and phospholipids (PLs) on the inner leaflet. The loss of this asymmetry due to mutations in the LPS biosynthesis o
Autor:
Neha Srikumar, Joseph Carver, Christoph Spiess, John C. Tran, Ambrose Williams, Yichin Liu, Amy Shen, Phillip Y. Chu, Cong Wu, Ankai Xu, William S. Sawyer
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance While electrospray ionization–mass spectrometry (ESI-MS) provides higher resolution for larger proteins, the conventional liquid chromatography (LC)-MS method suffers from low throughput. Our described RapidFire-MS workflow demonstrate
Autor:
Ramadevi Prathapam, Alexandra Frommlet, Jacob Shaul, Dita M. Rasper, Xiaoyu Shen, Alexey Ruzin, Sharadha Subramanian, Feng Wang, Micah Steffek, Bret Benton, Jason Vo, Steven Shia, Wooseok Han, Andreas O. Frank, Charles Wartchow, Patrick Lee, Xiaolei Ma, Fergal Casey, Hanne Merritt, Carl J. Balibar, Alun Bermingham, Elizabeth Ornelas, Tsuyoshi Uehara, Andreas Lingel, Chi-Min Ho, Barbara Chie-Leon, William S. Sawyer, Min-Kyu Cho, Sylvia Ma, Katherine R Prosen, Min Li, Christopher M. Rath, Gianfranco De Pascale
Publikováno v:
Journal of the American Chemical Society. 142:4445-4455
The lipopolysaccharide biosynthesis pathway is considered an attractive drug target against the rising threat of multi-drug-resistant Gram-negative bacteria. Here, we report two novel small-molecule inhibitors (compounds 1 and 2) of the acyltransfera
Autor:
Volker Schellenberger, David Fischer, Bing Zheng, Thomas H. Pillow, Amrita V. Kamath, Carl Ng, Jan Marik, Corinna Lei, Dorothea Reilly, Shabkhaiz Masih, Kelly M. Loyet, Vladimir N. Podust, Kimberly Kajihara, Maciej Paluch, Andrew Polson, Gail Dianne Phillips, Summer Park, Luna Liu, Morisaki John Hiroshi, Kai Zheng, Guangmin Li, Dian Su, Douglas D. Leipold, Josefa Chuh, Victor Yip, Emily Dong, Shang-Fan Yu, Wouter L. W. Hazenbos, Jack Sadowsky, Geoffrey Del Rosario, Rebecca K. Rowntree, Jeff N. Tinianow, Neelie Zacharias, Min Xu, William S. Sawyer, Katherine R. Kozak, Hilda Hernandez-Barry, Jintang He, Cong Wu, Keyang Xu, Ben-Quan Shen
Antibody-drug conjugates (ADCs) enable cell-specific delivery of small molecules and are validated anti-cancer therapeutics. One factor limiting ADC advancement and broader application is the drug-to-antibody ratio (DAR), which dictates the number of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a7d05e7d54cc2ba403b546592bdee064
https://doi.org/10.21203/rs.3.rs-356231/v1
https://doi.org/10.21203/rs.3.rs-356231/v1
Autor:
Steven J. Hartman, Ying Lu, Wentao Wei, Hao Zhou, Geoffrey Del Rosario, Robert A. Blake, Xiaoyu Zhu, Nicholas Corr, Aaron Fullerton, Shang-Fan Yu, Peter S. Dragovich, Jing Wang, Rebecca K. Rowntree, Donglu Zhang, Hui Yao, Emel Adaligil, Fan Jiang, Hongyan Zhang, Jack Sadowsky, John S. Wai, Jinhua Chen, Thomas H. Pillow, Susan Kaufman, Zijin Xu, Katherine R. Kozak, Jeremy Murray, Shenhua Zhang, Leanna Staben, Josefa dela Cruz-Chuh, Pragya Adhikari, Aimee O'Donohue, Tracy Kleinheinz, Liling Liu, Melinda M. Mulvihill, William S. Sawyer, Yongxin Zhao, Binqing Wei
Publikováno v:
Journal of medicinal chemistry. 64(5)
Heterobifunctional compounds that direct the ubiquitination of intracellular proteins in a targeted manner via co-opted ubiquitin ligases have enormous potential to transform the field of medicinal chemistry. These chimeric molecules, often termed pr