Zobrazeno 1 - 10
of 42
pro vyhledávání: '"William S. Noble"'
Autor:
Robin Aguilar, Conor K. Camplisson, Qiaoyi Lin, Karen H. Miga, William S. Noble, Brian J. Beliveau
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Fluorescent in situ hybridization (FISH) is a powerful method for the targeted visualization of nucleic acids in their native contexts. Recent technological advances have leveraged computationally designed oligonucleotide (oligo) probes to i
Externí odkaz:
https://doaj.org/article/11b986022f7646e6b02f240607074f00
Autor:
Rui Yang, Arnav Das, Vianne R. Gao, Alireza Karbalayghareh, William S. Noble, Jeffrey A. Bilmes, Christina S. Leslie
Publikováno v:
Genome Biology, Vol 25, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/9e27b8675a2a42da9d2482ac953dcd45
Autor:
Rui Yang, Arnav Das, Vianne R. Gao, Alireza Karbalayghareh, William S. Noble, Jeffrey A. Bilmes, Christina S. Leslie
Publikováno v:
Genome Biology, Vol 24, Iss 1, Pp 1-26 (2023)
Abstract Recent deep learning models that predict the Hi-C contact map from DNA sequence achieve promising accuracy but cannot generalize to new cell types and or even capture differences among training cell types. We propose Epiphany, a neural netwo
Externí odkaz:
https://doaj.org/article/03e9075f1972485484f1aafb6af44eb5
Dynamic chromatin organization and regulatory interactions in human endothelial cell differentiation
Autor:
Kris G. Alavattam, Katie A. Mitzelfelt, Giancarlo Bonora, Paul A. Fields, Xiulan Yang, Han Sheng Chiu, Lil Pabon, Alessandro Bertero, Nathan J. Palpant, William S. Noble, Charles E. Murry
Publikováno v:
Stem Cell Reports, Vol 18, Iss 1, Pp 159-174 (2023)
Summary: Vascular endothelial cells are a mesoderm-derived lineage with many essential functions, including angiogenesis and coagulation. The gene-regulatory mechanisms underpinning endothelial specialization are largely unknown, as are the roles of
Externí odkaz:
https://doaj.org/article/5f7f366be7be4a3e89f754bffcd612c1
Autor:
Giancarlo Bonora, Vijay Ramani, Ritambhara Singh, He Fang, Dana L. Jackson, Sanjay Srivatsan, Ruolan Qiu, Choli Lee, Cole Trapnell, Jay Shendure, Zhijun Duan, Xinxian Deng, William S. Noble, Christine M. Disteche
Publikováno v:
Genome Biology, Vol 22, Iss 1, Pp 1-36 (2021)
Abstract Background Mammalian development is associated with extensive changes in gene expression, chromatin accessibility, and nuclear structure. Here, we follow such changes associated with mouse embryonic stem cell differentiation and X inactivati
Externí odkaz:
https://doaj.org/article/2c9de6e28d644156acdf2680b105da84
Autor:
He Fang, Giancarlo Bonora, Jordan P. Lewandowski, Jitendra Thakur, Galina N. Filippova, Steven Henikoff, Jay Shendure, Zhijun Duan, John L. Rinn, Xinxian Deng, William S. Noble, Christine M. Disteche
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Firre encodes a lncRNA involved in nuclear organization in mammals. Here, the authors find that allelic deletion of Firre on the active X chromosome (Xa) results in dose-dependent loss of histone H3K27me3 on the inactive X chromosome (Xi), along with
Externí odkaz:
https://doaj.org/article/f2fa1372c67040d5a7985930598deed0
Autor:
Alessandro Bertero, Paul A. Fields, Vijay Ramani, Giancarlo Bonora, Galip G. Yardimci, Hans Reinecke, Lil Pabon, William S. Noble, Jay Shendure, Charles E. Murry
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-19 (2019)
The spatial organization of the genome plays an important but unclearly defined role in gene regulation. Here, the authors integrate Hi-C, RNA-seq and ATAC-seq data to map cardiogenesis from pluripotent stem cells and describe an RBM20-dependent spli
Externí odkaz:
https://doaj.org/article/a51e8f8741a942b2bf348aa7a7f3475f
Autor:
Galip Gürkan Yardımcı, Hakan Ozadam, Michael E. G. Sauria, Oana Ursu, Koon-Kiu Yan, Tao Yang, Abhijit Chakraborty, Arya Kaul, Bryan R. Lajoie, Fan Song, Ye Zhan, Ferhat Ay, Mark Gerstein, Anshul Kundaje, Qunhua Li, James Taylor, Feng Yue, Job Dekker, William S. Noble
Publikováno v:
Genome Biology, Vol 20, Iss 1, Pp 1-19 (2019)
Abstract Background Hi-C is currently the most widely used assay to investigate the 3D organization of the genome and to study its role in gene regulation, DNA replication, and disease. However, Hi-C experiments are costly to perform and involve mult
Externí odkaz:
https://doaj.org/article/c5c3304bc21c457993be8f6384642f01
Autor:
Jie Liu, John T. Halloran, Jeffrey A. Bilmes, Riza M. Daza, Choli Lee, Elisabeth M. Mahen, Donna Prunkard, Chaozhong Song, Sibel Blau, Michael O. Dorschner, Vijayakrishna K. Gadi, Jay Shendure, C. Anthony Blau, William S. Noble
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Abstract A comprehensive characterization of tumor genetic heterogeneity is critical for understanding how cancers evolve and escape treatment. Although many algorithms have been developed for capturing tumor heterogeneity, they are designed for anal
Externí odkaz:
https://doaj.org/article/c58b18b457184aafaf83bba3e97a5fdf
Autor:
Joel B. Berletch, Wenxiu Ma, Fan Yang, Jay Shendure, William S. Noble, Christine M. Disteche, Xinxian Deng
Publikováno v:
Data in Brief, Vol 5, Iss C, Pp 761-769 (2015)
X chromosome inactivation (XCI) is a female-specific mechanism that serves to balance gene dosage between the sexes whereby one X chromosome in females is inactivated during early development. Despite this silencing, a small portion of genes escape i
Externí odkaz:
https://doaj.org/article/94343594b6494fc3b20a2670c75002bf