Zobrazeno 1 - 10
of 34
pro vyhledávání: '"William S. MacLachlan"'
Autor:
Ian R. Cooper, Ronald Grigg, Laura A. T. Cleghorn, Colin W. G. Fishwick, William S. MacLachlan, Marcello Rasparini, Visuvanathar Sridharan
Publikováno v:
Journal of Organometallic Chemistry. 687:483-493
A new general three-component Pd/In bimetallic cascade reaction with four synthetic variants involving aryl iodides, allenes and C=X compounds affording homoallylic alcohols/amines as products is described and exemplified for Class 1 processes (inter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::35a9ec6cb4deaa2328a2a6d199a20504
https://doi.org/10.1016/j.jorganchem.2003.09.047
https://doi.org/10.1016/j.jorganchem.2003.09.047
Autor:
Ronald Grigg, Laura A. T. Cleghorn, Visuvanathar Sridharan, William S. MacLachlan, Ian R. Cooper
Publikováno v:
Tetrahedron Letters. 44:7969-7973
The effect of adding 1 equiv. of an amine or 0.2 equiv. of CuI to a Pd/In bimetallic cascade reaction is described. In the class 1 cascade reaction of aldehydes, aryl iodides and allene, generating homoallylic alcohols, the reaction time is reduced f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::624225fef83fb9a97f142536fcd399ac
https://doi.org/10.1016/j.tetlet.2003.08.103
https://doi.org/10.1016/j.tetlet.2003.08.103
Autor:
Ronald Grigg, Selvaratnam Suganthan, Visuvanathar Sridharan, David MacPherson, William S. MacLachlan
Publikováno v:
Tetrahedron. 57:10335-10345
Up to four bonds and five stereocentres are created, in five component processes (five point diversity), utilising resin bound aryl iodides by hydroboration or hydrostannylation of alkynes, followed by cyclisation–anion capture involving Suzuki or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ec60848468de380a3ae40c5de0bca772
https://doi.org/10.1016/s0040-4020(01)01061-4
https://doi.org/10.1016/s0040-4020(01)01061-4
Publikováno v:
Drug Discovery Today. 5:521-527
Automation in medicinal chemistry is often seen simply as a part of the combinatorial chemistry technologies used to meet the need for large, diverse screening collections for lead generation. However, the application of automation to the lead optimi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::343c1a3d3225b9e8e05a35069b6dd1f8
https://doi.org/10.1016/s1359-6446(00)01571-3
https://doi.org/10.1016/s1359-6446(00)01571-3
Autor:
Jin Zhang, Ronald Grigg, Mark Thornton-Pett, Macpherson David T, Selvaratnam Suganthan, William S. MacLachlan, Visuvanathar Sridharan
Publikováno v:
Tetrahedron. 56:6585-6594
The tactical combination of the Pictet–Spengler reaction with Pd catalyzed reactions with allene and with carbon monoxide provides rapid access to a range of tetrahydro-β-carboline and tetrahydroisoquinoline derivatives via intramolecular trapping
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d377bf029ab42840fdeede05f946094d
https://doi.org/10.1016/s0040-4020(00)00628-1
https://doi.org/10.1016/s0040-4020(00)00628-1
Autor:
Mark Thornton-Pett, Visuvanathar Sridharan, Ronald Grigg, Selvaratnam Suganthan, Macpherson David T, William S. MacLachlan, H. Ali Dondas, Jasothara Duraisingham
Publikováno v:
Tetrahedron. 56:4063-4070
The combination of thermal or Ag(I) catalysed imine→azomethine ylide→cycloaddition cascades with a subsequent Pictet–Spengler reaction allows the assembly of polyfunctional N-heterocycles, via formation of 4 bonds and 2 rings, in good yield.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2e10b3295f932b0a9b07d23e53f7308f
https://doi.org/10.1016/s0040-4020(00)00320-3
https://doi.org/10.1016/s0040-4020(00)00320-3
Autor:
William S. MacLachlan, H. Ali Dondas, Ronald Grigg, Selveratnam Suganthan, Macpherson David T, Jasothara Markandu, Visuvanathar Sridharan
Publikováno v:
Tetrahedron Letters. 41:967-970
Up to six bonds and two rings can be created, in five component processes (five points of diversity), by AgOAc catalysed imine cycloaddition to Wang resin acrylate followed by Pictet–Spengler and Pd(0) catalysed reactions.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ef9913ef49850078cb8293b83a38bdde
https://doi.org/10.1016/s0040-4039(99)02183-8
https://doi.org/10.1016/s0040-4039(99)02183-8
Autor:
Paul Brooking, Nicholas W. Hird, Stephen Wilding, William S. MacLachlan, Simon A. Readshaw, Claire Jones, Melanie Crawshaw
Publikováno v:
Synthesis. 1999:1986-1992
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::afbf2e2149c1ed594c5fcf3f554be585
https://doi.org/10.1055/s-1999-3615
https://doi.org/10.1055/s-1999-3615
Autor:
William S. MacLachlan, Mythily Vimal, Nicholas W. Hird, Paul Grimsey, Paul Brooking, Andrew Doran
Publikováno v:
Tetrahedron Letters. 40:1405-1408
A multiple synthesiser approach to high efficiency, high throughput synthesis is described. It involves eliminating duplication in multi-step synthesis by establishing a cascade of matched synthesisers in which each machine performs a single step and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::af0bd7fddfb5a5149eef2b1fc782c394
https://doi.org/10.1016/s0040-4039(98)02620-3
https://doi.org/10.1016/s0040-4039(98)02620-3
Publikováno v:
Tetrahedron Letters. 36:1735-1738
Stereoselective hydroboration of 6 affords, after further manipulation, 13-dehydroxy-(14 S )-hydroxyamphotericin B methyl ester 9 , the first amphotericin B derivative with a saturated ether function at C-13.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c04a64ae0e4369fd041bab6c03988ce7
https://doi.org/10.1016/0040-4039(95)00105-l
https://doi.org/10.1016/0040-4039(95)00105-l