Zobrazeno 1 - 5
of 5
pro vyhledávání: '"William S. Fillers"'
Autor:
Gary M. Coppola, Xilin Liu, Robert C. Anderson, Douglas C. Knorr, William S. Fillers, James L. Stanton, Jiaping Gao, Tomaselli Hc, Christine C. Vinluan, Thomas Daniel Aicher, Carol J. Dragland, Suraj S. Shetty, Wieslawa Maniara, A. Islam, Emma L. Kaplan, William R. Mann, Leonard J. Brand, Donald Mark Sperbeck, R. E. Walter, Dominick DelGrande, R. J. Lozito
Publikováno v:
Journal of Medicinal Chemistry. 43:236-249
N‘-Methyl-N-(4-tert-butyl-1,2,5,6-tetrahydropyridine)thiourea, SDZ048-619 (1), is a modest inhibitor (IC50 = 180 μM) of pyruvate dehydrogenase kinase (PDHK). In an optimization of the N-methylcarbothioamide moiety of 1, it was discovered that amid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5a21921472d2095e7c5eea09d6d92805
https://doi.org/10.1021/jm990358+
https://doi.org/10.1021/jm990358+
Autor:
Cheon Seung Hoon, Leonard J. Brand, Jeffrey Nadelson, Christina L. Leone, Rhonda O. Deems, Howard C. Smith, Douglas C. Knorr, Philip A. Bell, William S. Fillers, Thomas Daniel Aicher, Fell Jay Bradford, Ronald Simpson, Bork Balkan, Fraser James D, Gerald G. Kahle, Jiaping Gao
Publikováno v:
Journal of Medicinal Chemistry. 41:4556-4566
A series of substituted tetrahydropyrrolo[2,1-b]oxazol-5(6H)-ones and tetrahydropyrrolo[2,1-b]thiazol-5(6H)-ones was synthesized from amino alcohols or amino thiols and keto acids. A pharmacological model based on the results obtained with these comp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb31ffd5d78f113f76722b9919a226c6
https://doi.org/10.1021/jm9803121
https://doi.org/10.1021/jm9803121
Autor:
Dario A. Otero, Philip A. Bell, Jeremy G. Dain, Thomas Daniel Aicher, Jeffrey Nadelson, Robert J. Strohschein, Leonard J. Brand, Douglas C. Knorr, James E. Foley, Douglas A. Young, Gregory Raymond Bebernitz, Ronald Simpson, William S. Fillers, Rhonda O. Deems
Publikováno v:
Journal of medicinal chemistry. 42(1)
SAH 51-641 (1) is a potent hypoglycemic agent, which acts by inhibiting hepatic gluconeogenesis. It is a prodrug of 4-(2, 2-dimethyl-1-oxopropyl)benzoic acid (2) and 4-(2, 2-dimethyl-1-hydroxypropyl)benzoic acid (3), which sequester coenzyme A (CoA)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::744d8ab1f1a528d95ddc2bf1adb00384
https://pubmed.ncbi.nlm.nih.gov/9888840
https://pubmed.ncbi.nlm.nih.gov/9888840
Autor:
William R. Mann, Philip A. Bell, William S. Fillers, Robert C. Anderson, Michael Balestra, Fraser James D, Markus Rudin, Rhonda O. Deems, Edwin Bernard Villhauer, James E. Foley
Publikováno v:
Journal of medicinal chemistry. 38(18)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9b8ff04be369119e1dceea0bb7aa902
https://pubmed.ncbi.nlm.nih.gov/7658430
https://pubmed.ncbi.nlm.nih.gov/7658430
Autor:
Samuel Chacko, William S. Fillers
Publikováno v:
Biochemistry. 26:5896-5903
Actin activation of the adenosinetriphosphatase (ATPase) of phosphorylated gizzard myosin at low (2 mM) free Mg2+ concentration and 50 mM total ionic strength continues to increase on raising the free Ca2+ concentration near pCa 3. Similar levels of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8d32ab2eb58d83bf923073f6bf0e051
https://doi.org/10.1021/bi00392a048
https://doi.org/10.1021/bi00392a048