Zobrazeno 1 - 10
of 22
pro vyhledávání: '"William S. Eng"'
Autor:
Daniel Bojar, David F. Smith, Lara K. Mahal, Richard D. Cummings, William S. Eng, Guanmin Meng, Lawrence Meche
Glycans are critical to every facet of biology and medicine, from viral infections to embryogenesis. Tools to study glycans are rapidly evolving, however the majority of our knowledge is deeply dependent on binding by glycan binding proteins (e.g., l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccf96840fb78bb338a0813140b9d58e0
https://doi.org/10.1101/2021.08.31.458439
https://doi.org/10.1101/2021.08.31.458439
Autor:
William S. Eng, Christina C. Spevak, Caryn J. Ha, Gaëlle H. Martin, Harold Elias, Vinagolu K. Rajasekhar, Carolien M. Woolthuis, Christopher Y. Park, Lavanya Kannan, Amanda Ernlund, Guangjie Zhao, Shanmugapriya Selvaraj, Robert J. Schneider, Mohamed A.E. Ali
Publikováno v:
Cell Stem Cell
Cell stem cell, 26(5), 755-765.e7. CELL PRESS
Cell stem cell, 26(5), 755-765.e7. CELL PRESS
Hematopoietic stem cells (HSCs) require highly regulated rates of protein synthesis, but it is unclear if they or lineage-committed progenitors preferentially recruit transcripts to translating ribosomes. We utilized polysome profiling, RNA sequencin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e920664658a771fd7e99fc26e3dcdaae
https://europepmc.org/articles/PMC9435590/
https://europepmc.org/articles/PMC9435590/
Autor:
Christopher Y. Park, Amanda Ernlund, Gaëlle H. Martin, Lavanya Kannan, Robert J. Schneider, Carolien M. Woolthuis, Harold Elias, Vinagolu K. Rajasekhar, William S. Eng, Christina C. Spevak, Shanmugapriya Selvaraj
Publikováno v:
Molecular Cancer Research. 18:PR06-PR06
Acute myeloid leukemia (AML) is a clonal disorder of hematopoiesis originating in hematopoietic/stem progenitor cells characterized by impaired differentiation and the accumulation of immature blasts in the bone marrow. While genetic, transcriptional
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fb3003f9c5d74af5a9901ad7f55d1d0e
https://doi.org/10.1158/1557-3125.pi3k-mtor18-pr06
https://doi.org/10.1158/1557-3125.pi3k-mtor18-pr06
Autor:
Ari Melnick, Ross L. Levine, Mona Khalaj, Stephen S. Chung, Montreh Tavakkoli, Martin Carroll, Wenhuo Hu, Christopher Y. Park, Virginia M. Klimek, William S. Eng, Francine E. Garrett-Bakelman
Publikováno v:
Science Translational Medicine. 9
Acute myeloid leukemia (AML) and the myelodysplastic syndromes (MDS) are initiated and sustained by self-renewing malignant stem cells; thus, eradication of AML and MDS stem cells is required for cure. We identified CD99 as a cell surface protein fre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a31610de2db32d2cf62814fc58d2acc0
https://doi.org/10.1126/scitranslmed.aaj2025
https://doi.org/10.1126/scitranslmed.aaj2025
Autor:
David R. Colquhoun, Rhoel R. Dinglasan, David R. Graham, William S. Eng, Lara K. Mahal, Yaxuan Liang
Publikováno v:
Journal of Biological Chemistry
Exosomes, also known as microvesicles (EMVs), are nano-sized membranous particles secreted from nearly all mammalian cell types. These nanoparticles play critical roles in many physiological processes including cell-cell signaling, immune activation,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ceb85db5427cd2c89d1fec0ae2466dc
https://doi.org/10.1074/jbc.m114.606269
https://doi.org/10.1074/jbc.m114.606269
Autor:
Linlin Wang, Lara K. Mahal, Jeffrey C. Gildersleeve, Richard D. Cummings, Jared Q. Gerlach, Sonia Serna, Lokesh Joshi, Núria Parera Pera, David F. Smith, William S. Eng, Niels-Christian Reichardt, Margaret E. Huflejt, Michelle Kilcoyne, Roland J. Pieters, Christopher T. Campbell
Publikováno v:
Glycobiology; Vol 24
Glycobiology
Glycobiology
Carbohydrates participate in almost every aspect of biology from protein sorting to modulating cell differentiation and cell-cell interactions. To date, the majority of data gathered on glycan expression has been obtained via analysis with either ant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adf28393d11b04483d1c95fd9a273c4a
https://doi.org/10.1093/glycob/cwu019
https://doi.org/10.1093/glycob/cwu019
Autor:
Shanmugapriya Selvaraj, William S. Eng, Gaëlle H. Martin, Guangjie Zhao, Mohamed A.E. Ali, Christopher Y. Park, Carolien M. Woolthuis, Amanda Ernlund, Harold Elias, Vinagolu K. Rajasekhar, Lavanya Kannan, Robert J. Schneider, Christina C. Spevak
Publikováno v:
Blood. 134:1180-1180
Prior studies in numerous biological systems have shown that alterations in mRNA expression frequently fail to predict changes in protein expression. This may be due to many regulatory mechanisms that occur post-transcriptionally including mRNA recru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a5a18d429505fc17bb9e4ef354539a3b
https://doi.org/10.1182/blood-2019-131333
https://doi.org/10.1182/blood-2019-131333
Autor:
William S. Eng, Karen D. Hendricks-Muñoz, Lara K. Mahal, Kanoelani T. Pilobello, Bianca S. Batista
Publikováno v:
Journal of Proteome Research. 10:4624-4633
Microvesicles (exosomes) are important mediators of intercellular communication, playing a role in immune regulation, cancer progression and the spread of infectious agents. The biological functions of these small vesicles are dependent upon their co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97c120ecee77333ad2432992872d69f6
https://doi.org/10.1021/pr200434y
https://doi.org/10.1021/pr200434y
Autor:
Claudio G. Giraudo, Ai Yamamoto, Thomas J. Melia, Alejandro Garcia-Diaz, William S. Eng, James E. Rothman
Publikováno v:
Journal of Biological Chemistry. 283:21211-21219
In regulated exocytosis, the core membrane fusion machinery proteins, the SNARE proteins, are assisted by a group of regulatory factors in order to couple membrane fusion to an increase of intracellular calcium ion (Ca2+) concentration. Complexin-I a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::647b152cee6dee48223594bfd15fb0da
https://doi.org/10.1074/jbc.m803478200
https://doi.org/10.1074/jbc.m803478200
Autor:
Thomas H. Söllner, James E. Rothman, Mariella Ravazzola, Maurizio Di Liberto, Masayoshi Fukasawa, Allen Volchuk, Thomas Engel, Lelio Orci, Oleg Varlamov, Alain Perrelet, William S. Eng
Publikováno v:
Molecular Biology of the Cell. 15:1506-1518
Genetic and biochemical evidence has established that a SNARE complex consisting of syntaxin 5 (Sed5)-mYkt6 (Ykt6)-GOS28 (Gos1)-GS15 (Sft1) is required for transport of proteins across the Golgi stack in animals (yeast). We have utilized quantitative
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c606a2c3107b34914063c4fdb91b951
https://doi.org/10.1091/mbc.e03-08-0625
https://doi.org/10.1091/mbc.e03-08-0625