Zobrazeno 1 - 10
of 39
pro vyhledávání: '"William S. Denney"'
Autor:
Jocelyn H. Leu, An Vermeulen, Claudia Abbes, Santiago Arroyo, William S. Denney, Leona E. Ling
Publikováno v:
Frontiers in Neuroscience, Vol 18 (2024)
IntroductionNipocalimab is a high-affinity, fully human, aglycosylated, effectorless, immunoglobulin G (IgG) 1 monoclonal antibody that targets the neonatal Fc receptor (FcRn), decreases systemic IgG including autoantibodies, and is under development
Externí odkaz:
https://doaj.org/article/b0db3a96072d4cefb2aece1ceaf0708f
Autor:
Mark R. Charbonneau, William S. Denney, Nicholas G. Horvath, Pasquale Cantarella, Mary J. Castillo, Marja K. Puurunen, Aoife M. Brennan
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
Mark Charbonneau et al. develop a mathematical model that describes the behavior of an engineered bacterial therapeutic, SYNB1618, in the human gastrointestinal tract and its effects on plasma phenylalanine (Phe) levels. This model enables the author
Externí odkaz:
https://doaj.org/article/9c842b6d19dd4ea5ab162237138ababd
Publikováno v:
Cell Reports Medicine, Vol 1, Iss 4, Pp 100057- (2020)
Summary: Experimental fibroblast growth factor 21 (FGF21) analogs can improve lipid profiles in patients with metabolic diseases. However, their effects on markers of insulin sensitivity appear to be minimal, potentially because of insufficient expos
Externí odkaz:
https://doaj.org/article/ff70adc410394e34a7243a26c6816dac
Autor:
Aoife M. Brennan, Larry Blankstein, Mark R. Charbonneau, Mary Castillo, John A. Phillips, Benjamin D. Goodlett, William S. Denney, Caroline B. Kurtz, David A. Wagner, Jerry Vockley, Marja K. Puurunen, Stephanie Sacharow, Vincent M. Isabella, Vasu V. Sethuraman, Richard Riese, Shawn Searle
Publikováno v:
Nature Metabolism. 3:1125-1132
Phenylketonuria (PKU) is a rare disease caused by biallelic mutations in the PAH gene that result in an inability to convert phenylalanine (Phe) to tyrosine, elevated blood Phe levels and severe neurological complications if untreated. Most patients
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1342478a5d170a500dcfa6ea1b086228
https://doi.org/10.1038/s42255-021-00430-7
https://doi.org/10.1038/s42255-021-00430-7
Autor:
Caroline B. Kurtz, Richard Riese, Shawn Searle, Aoife M. Brennan, Sushama Scalera, William S. Denney, David Lubkowicz, Andrew Marsh, Marja K. Puurunen
Publikováno v:
Journal of Urology. 206
INTRODUCTION AND OBJECTIVE:High urinary oxalate levels (UOx) in patients with enteric hyperoxaluria (EH) can lead to recurrent kidney stones, nephrocalcinosis and chronic kidney disease (CKD). Ther...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::112530009ec3c293263a9a925e57b172
https://doi.org/10.1097/ju.0000000000002010.10
https://doi.org/10.1097/ju.0000000000002010.10
Autor:
Aoife M. Brennan, Nicholas G. Horvath, William S. Denney, Mary Castillo, Pasquale Cantarella, Mark R. Charbonneau, Marja K. Puurunen
Publikováno v:
Communications Biology
Communications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
Communications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
The development of therapeutics depends on predictions of clinical activity from pre-clinical data. We have previously described SYNB1618, an engineered bacterial therapeutic (synthetic biotic) for the treatment of Phenylketonuria (PKU), a rare genet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d96870b0f2136283ec18a8b4d6c36f2
https://doi.org/10.1038/s42003-021-02183-1
https://doi.org/10.1038/s42003-021-02183-1
Autor:
Marja K. Puurunen, Jerry Vockley, Shawn L. Searle, Stephanie J. Sacharow, John A. Phillips, William S. Denney, Benjamin D. Goodlett, David A. Wagner, Larry Blankstein, Mary J. Castillo, Mark R. Charbonneau, Vincent M. Isabella, Vasu V. Sethuraman, Richard J. Riese, Caroline B. Kurtz, Aoife M. Brennan
Publikováno v:
Nature Metabolism. 4:1214-1214
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::05de650ff6c47d4b608240b7940f8363
https://doi.org/10.1038/s42255-022-00635-4
https://doi.org/10.1038/s42255-022-00635-4
Autor:
Marja K, Puurunen, Jerry, Vockley, Shawn L, Searle, Stephanie J, Sacharow, John A, Phillips, William S, Denney, Benjamin D, Goodlett, David A, Wagner, Larry, Blankstein, Mary J, Castillo, Mark R, Charbonneau, Vincent M, Isabella, Vasu V, Sethuraman, Richard J, Riese, Caroline B, Kurtz, Aoife M, Brennan
Publikováno v:
Nature metabolism. 3(8)
Phenylketonuria (PKU) is a rare disease caused by biallelic mutations in the PAH gene that result in an inability to convert phenylalanine (Phe) to tyrosine, elevated blood Phe levels and severe neurological complications if untreated. Most patients
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f82627a32b8de2935eacdf630d65bebf
https://pubmed.ncbi.nlm.nih.gov/35974248
https://pubmed.ncbi.nlm.nih.gov/35974248
Autor:
Heather K Knych, William S. Denney, Vernon C. Langston, Robert E. Meyer, Claudio Correa Natalini, Robin L. Fontenot, Sarah E. Shane, Robert W. Wills
Publikováno v:
Journal of veterinary pharmacology and therapeuticsREFERENCES. 44(4)
An ideal dexmedetomidine protocol has yet to be determined for standing sedation in horses. It was hypothesized that an IV bolus followed by CRI dexmedetomidine would have a quicker increase in plasma concentrations compared with repeated IM injectio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16a169389df8d6c161bac9c75e172756
https://pubmed.ncbi.nlm.nih.gov/33576078
https://pubmed.ncbi.nlm.nih.gov/33576078
Publikováno v:
Molecular Genetics and Metabolism. 135:295
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5a0b470a021265d8d3251a844c7eeaf0
https://doi.org/10.1016/j.ymgme.2022.01.079
https://doi.org/10.1016/j.ymgme.2022.01.079