Zobrazeno 1 - 10
of 22
pro vyhledávání: '"William S. Caldwell"'
Autor:
Jenny Z. Zhang, Jarrett J. Farias, Bhatti Balwinder Singh, William S. Caldwell, Jon-Paul Strachan
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:5089-5092
Diazaspirocyclic ligands have been synthesized in four steps as selective α4β2 nicotinic acetylcholine receptor antagonists. Structural assignment of 1-(pyridin-3-yl)-2-spiropyrrolidino-3,2'-1-azabiclo[2.2.1]heptane 2, was confirmed using a combina
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fe901dbe1ab3142b83b7eaf912f1776
https://doi.org/10.1016/j.bmcl.2012.05.108
https://doi.org/10.1016/j.bmcl.2012.05.108
Autor:
Rachel Pellerin, Jesus Benavides, Arielle Genevois-Borella, Leconte Jean-Pierre, Michel Laville, Gregory J. Gatto, Georg Andrees Bohme, Obinu Marie-Carmen, Odile Piot-Grosjean, Laurent Pradier, Martine Mazadier, Pascale Brunel, Sharon R. Letchworth, Merouane Bencherif, William S. Caldwell, Pierre Dubedat
Publikováno v:
Drug Development Research. 62:26-40
Nicotine activates specific receptors that are cation-permeable ionic channels located in the central and autonomous nervous systems, as well as at the neuromuscular junction. Administration of nicotine to animals and humans has been shown to enhance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::329c52b32f975a7c05482de3befc5772
https://doi.org/10.1002/ddr.10352
https://doi.org/10.1002/ddr.10352
Publikováno v:
CNS Drug Reviews. 3:325-345
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::32d706ab7994438ae0eaef5283c73043
https://doi.org/10.1111/j.1527-3458.1997.tb00331.x
https://doi.org/10.1111/j.1527-3458.1997.tb00331.x
Autor:
Peter A. Crooks, Robert Mack Riggs, K. M. Chang, J. M. Greene, J. D. Debethizy, William S. Caldwell, Bhatti Balwinder Singh, M. S. Uhrig, Gary D. Byrd
Publikováno v:
Chemical Research in Toxicology. 5:280-285
Recent studies in our laboratories have confirmed that a major unidentified metabolite of nicotine in smokers' urine was susceptible to enzymatic degradation by beta-glucuronidase to afford (S)-(-)-cotinine. In order to establish the identity of this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9aea6013f56cfa4d07fe3160fca5444e
https://doi.org/10.1021/tx00026a021
https://doi.org/10.1021/tx00026a021
Autor:
Miller Craig H, William S. Caldwell, Bhatti Balwinder Singh, Peter A. Crooks, Cynthia S. Day, Jon-Paul Strachan, Scott R. Breining, Niranjan Madhukar Deo, Persida Tahiri
Publikováno v:
The Journal of organic chemistry. 73(9)
In an attempt to generate nicotinic acetylcholine receptor (nAChR) ligands selective for the alpha4beta2 and alpha7 subtype receptors we designed and synthesized constrained versions of anabasine, a naturally occurring nAChR ligand. 2-(Pyridin-3-yl)-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6682cc68f2b68064b8dda9b4395ea4a2
https://pubmed.ncbi.nlm.nih.gov/18363376
https://pubmed.ncbi.nlm.nih.gov/18363376
Autor:
William S Caldwell, James M Conner
Publikováno v:
Journal of AOAC INTERNATIONAL. 73:783-789
Studies In our laboratory revealed artlfactual formation of Nnltrosamlnes during trapping of mainstream and sldestream tobacco smoke by the method of Hoffmann and coworkers (2, 4). Both volatile and tobacco-specific Af-nltrosamlnes were produced. Thi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::08862bec447a1264d41579ffce603333
https://doi.org/10.1093/jaoac/73.5.783
https://doi.org/10.1093/jaoac/73.5.783
Publikováno v:
Drug metabolism and drug interactions. 16(4)
[Methyl-d3]-N-1-beta-D-glucopyranosyl-(+/-)-nicotinium inner salt ((+/-)-[methyl-d3]nicotine N-1-glucuronide) was synthesized from (+/-)-[methyl-d3]nicotine via reaction with methyl-2,3,4-tri-O-acetyl-1-bromodeoxy-alpha-D-glucopyranouronate, followed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13e8a8706578170a5ef897248c0d9e8c
https://pubmed.ncbi.nlm.nih.gov/11201307
https://pubmed.ncbi.nlm.nih.gov/11201307
Publikováno v:
Biochemistry. 34(8)
Kinetic isotope effects on association have been measured using the remote label methodology developed by O'Leary and Marlier (1979). The isotope effect on V/KA for the first substrate in an obligatorily ordered mechanism is an isotope effect on its
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5683f9b8cfc1d03e2139a577a2e028ca
https://pubmed.ncbi.nlm.nih.gov/7873538
https://pubmed.ncbi.nlm.nih.gov/7873538
Autor:
Robert Mack Riggs, William S. Caldwell, Peter A. Crooks, M. S. Uhrig, Gary D. Byrd, J. D. Debethizy, Alain Ravard
Publikováno v:
Biological mass spectrometry. 23(2)
A thermospray liquid chromatographic/mass spectrometric method has been developed for direct determination of cotinine-N-glucuronide in the urine of smokers. Quantification was performed using methyl-d3-cotinine-N-glucuronide as internal standard and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82df61cd640b13d7a841e9a27104f9ed
https://pubmed.ncbi.nlm.nih.gov/8123688
https://pubmed.ncbi.nlm.nih.gov/8123688
Autor:
F. Adlkofer, J. G. Besner, Alain Ravard, Peter A. Crooks, G. Singh, Jean-Louis Horn, Min Li, B. V. Rama Sastry, Neal L. Benowitz, A. R. Tricker, H. Klus, G. P. Dobson, Gerhard Scherer, Peyton Jacob, D. Doolittle, H. Taber, C. Kutzer, Gary D. Byrd, William S. Caldwell, C. Fulp, Dorothy K. Hatsukami, Elmar Richter, J.R. Idle, Donald deBethizy, Chin K. Lee, Bhatti Balwinder Singh, Julian B. S. Leathart, E. Johnstone, N. W. McCracken, S. E. Atawodi, D. J. deBethizv, K. Yan, M.B. Chance, Herb Severson, S. Cholerton, A. Arpanahi, John H. Robinson, M. Bouhajib, M Meger, G. M. Dull, Ann K. Daly, E. Bombick, V. E. Janson, A. Pachinger, Carol Boustead, Linda P. Dwoskin
Publikováno v:
Experientia Supplementum ISBN: 9783764350871
Recently, we have shown a significantly lower excretion of α-hydroxylation products of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in the urine of rats co-administered a 500-fold higher dose of nicotine (Richter et al., Naunyn Schmiedebergs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ae0cca7b2883718a039886b04c418158
https://doi.org/10.1007/978-3-0348-7416-8_20
https://doi.org/10.1007/978-3-0348-7416-8_20
