Zobrazeno 1 - 5
of 5
pro vyhledávání: '"William S. Bosan"'
Publikováno v:
Carcinogenesis. 7:413-418
Administration of the hepatotoxin and carcinogen, inorganic hydrazine, to rodents results in the formation of 7-methylguanine and O6-methylguanine in liver DNA; co-administration of [methyl-14C]methionine or [14C]formate with the hydrazine labels the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44ba12863798b1ca096ef2112014541b
https://doi.org/10.1093/carcin/7.3.413
https://doi.org/10.1093/carcin/7.3.413
Autor:
William S. Bosan, Ronald C. Shank
Earlier studies demonstrated that hydrazine administration to rodents results in the methylation of liver DNA guanine and that S-adenosylmethionine was the apparent methyl donor in this response. The present study characterized the hamster as an anim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::10f94185637c7a7acccfc697cec277db
https://doi.org/10.21236/ada132944
https://doi.org/10.21236/ada132944
Autor:
William S. Bosan, Ronald C. Shank
Publikováno v:
Toxicology and applied pharmacology. 70(2)
Formation of 7-methylguanine and O6-methylguanine in liver DNA was measured 24 hr after administration of various single oral doses of 15 to 120 mg hydrazine/kg body wt to Syrian golden hamsters, and at various times up to 96 hr after a single oral d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a55cb0e3da1c37a5716c12e6fc2abeff
https://pubmed.ncbi.nlm.nih.gov/6623473
https://pubmed.ncbi.nlm.nih.gov/6623473
Oral administration of the inorganic hepatotoxin, hydrazine, to male Fischer 344 or Sprague Dawley rats results in the endogenous methylation of liver DNA at the 7- and O6-positions of guanine. At doses below the LD50 (45, 60 or 75 mg hydrazine/kg bo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff3b968640aaa6887a711b2fd206b664
https://doi.org/10.21236/ada119124
https://doi.org/10.21236/ada119124
Publikováno v:
Carcinogenesis. 7(3)
Hydrazine induces methylation of target-organ DNA guanine; the methylation mechanism was proposed to involve reaction of hydrazine with endogenous formaldehyde. One possible condensation product of hydrazine and formaldehyde is tetraformyltrisazine (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c1e0c73ef17269125650268ee31ef5f
https://pubmed.ncbi.nlm.nih.gov/3948327
https://pubmed.ncbi.nlm.nih.gov/3948327