Zobrazeno 1 - 10
of 89
pro vyhledávání: '"William S. Baldwin"'
Autor:
Lanie A. Williams, Matthew C. Hamilton, Matthew L. Edin, Fred B. Lih, Jazmine A. Eccles-Miller, Nishanth Tharayil, Elizabeth Leonard, William S. Baldwin
Publikováno v:
Toxics, Vol 12, Iss 2, p 106 (2024)
Perfluorooctanesulfonate (PFOS) is a widespread environmental pollutant with a long half-life and clearly negative outcomes on metabolic diseases such as fatty liver disease and diabetes. Male and female Cyp2b-null and humanized CYP2B6-transgenic (hC
Externí odkaz:
https://doaj.org/article/c3a5bf7bc665410d9bd1806137db76a4
Publikováno v:
Data in Brief, Vol 41, Iss , Pp 108013- (2022)
Cytochrome P450 2B6 (CYP2B6) is a human enzyme important in chemical detoxification, steroid and fatty acid metabolism that is primarily hepatic. Therefore, induction or inhibition of CYP2B6 may perturb endo- and xenobiotic metabolism and cause adver
Externí odkaz:
https://doaj.org/article/12de062068304dfeab0bf6c687867507
Autor:
Melissa M. Heintz, Jazmine A. Eccles, Emily M. Olack, Kristal M. Maner-Smith, Eric A. Ortlund, William S. Baldwin
Publikováno v:
PLoS ONE, Vol 17, Iss 12 (2022)
Multiple factors in addition to over consumption lead to obesity and non-alcoholic fatty liver disease (NAFLD) in the United States and worldwide. CYP2B6 is the only human detoxification CYP whose loss is associated with obesity, and Cyp2b-null mice
Externí odkaz:
https://doaj.org/article/a8fba9fa4b8445c4aea5682d63887a42
Publikováno v:
Journal of Lipids, Vol 2022 (2022)
Increases in traditional serum lipid profiles are associated with obesity, cancer, and cardiovascular disease. Recent lipidomic analysis has indicated changes in serum lipidome profiles, especially in regard to specific phosphatidylcholines, associat
Externí odkaz:
https://doaj.org/article/c25dd50b9a7a4058be8a42064267d301
Autor:
Jazmine A. Eccles, William S. Baldwin
Publikováno v:
Cells, Vol 12, Iss 1, p 82 (2022)
This manuscript reviews the CYP-mediated production of oxylipins and the current known function of these diverse set of oxylipins with emphasis on the detoxification CYPs in families 1–3. Our knowledge of oxylipin function has greatly increased ove
Externí odkaz:
https://doaj.org/article/57cc123a2f82456fb1d191dd150e124d
Autor:
Emily E. Gessner, Manav H. Shah, Bricen N. Ghent, Nathaniel E. Westbrook, Peter van den Hurk, William S. Baldwin
Publikováno v:
Ecotoxicology
Carmofur is an antineoplastic agent that inhibits ceramidase, a key enzyme in the sphingolipid pathway. Previous research suggests carmofur represses reproductive maturity in Daphnia magna. The purpose of this experiment was to confirm carmofur’s e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d525d03da95984f2dd15dcb271dc6c9b
https://europepmc.org/articles/PMC9233140/
https://europepmc.org/articles/PMC9233140/
Publikováno v:
J Nutr Biochem
Obesity is an endemic problem in the United States and elsewhere, and data indicate that in addition to overconsumption, exposure to specific chemicals enhances obesity. CYP2B metabolizes multiple endo- and xenobiotics, and recent data suggests that
Autor:
Melissa M. Heintz, Emily Marques, Marisa Pfohl, William S. Baldwin, Matthew C. Hamilton, Angela L. Slitt, Lucie Ford
Publikováno v:
Food Chem Toxicol
PFOS is a persistent, fluorosurfactant used in multiple products. Murine Cyp2b's are induced by PFOS and high-fat diets (HFD) and therefore we hypothesized that human CYP2B6 may alleviate PFOS-induced steatosis. Cyp2b-null and hCYP2B6-Tg mice were tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4fcd69a304d10cda3a62064ebd905bd
https://europepmc.org/articles/PMC8154739/
https://europepmc.org/articles/PMC8154739/
Autor:
William S. Baldwin, Brittany E. Harlow, Maslyn A Greene, Jack P. Goodman, J. L. Britt, James R Strickland, Susan K. Duckett, James L. Klotz, John May, F. Neal Schrick
Publikováno v:
Translational Animal Science
Gestating ewes consuming ergot alkaloids, from endophyte-infected (E+) tall fescue seed, suffer from intrauterine growth restriction and produce smaller lambs. Arginine (Arg) supplementation has been shown to increase birth weight and oral citrulline
Autor:
Maslyn A Greene, James L Klotz, Jack P Goodman, John B May, Brittany M Harlow, William S Baldwin, James R Strickland, Jessica L Britt, F. N. Schrick, Susan K Duckett
Background: Gestating ewes consuming ergot alkaloids, from endophyte-infected (E+) tall fescue seed, produce smaller lambs suffering from intrauterine growth restriction. Arginine (Arg) supplementation has been shown to increase birth weight and oral
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e4a06e1aae76f00a9741d6dc4e5b58b2
https://doi.org/10.21203/rs.3.rs-63431/v1
https://doi.org/10.21203/rs.3.rs-63431/v1