Report on the international workshop on alternatives to the murine histamine sensitization test (HIST) for acellular pertussis vaccines: State of the science and the path forward

Autor: Vivian W. Doelling, Warren Casey, Sue Nelson, Dorothy Xing, Brett Jones, Jean-Michel Chapsal, William S. Stokes, Christina Bache, Marlies Halder, Catherine S. Sprankle, Lori Rinckel, Richard McFarland, Amélie Castiaux, Angele Costanzo, Richard Isbrucker, Nelson W Johnson, Juan Arciniega, Marieke Hoonakker

Publikováno v: Biologicals. 42:114-122

Regulatory authorities require safety and potency testing prior to the release of each production lot of acellular pertussis (aP)-containing vaccines. Currently, the murine histamine sensitization test (HIST) is used to evaluate the presence of resid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::64823bb1795120fddeaa6e05eb344e94
https://doi.org/10.1016/j.biologicals.2013.11.011

Report on the international workshop on alternative methods for human and veterinary rabies vaccine testing: State of the science and planning the way forward

Autor: Marlies Halder, Brett Jones, Warren Casey, Timothy J. Miller, Jodie Kulpa-Eddy, Peter S. Wunderli, Karen Brown, David L. Reed, Richard Hill, Vivian W. Doelling, Hajime Kojima, Jean-Michel Chapsal, William S. Stokes, Fabrizio De Mattia, Charles E. Rupprecht, Robin Levis, Lukas Bruckner, Gayle Pulle, Sunil Gairola, Richard McFarland, Nelson W Johnson, Donna M. Gatewood, Lori Rinckel, Koichiro Gamoh, Charles E. Lewis, Alexander Gaydamaka, David J. Allen, Lorraine M. McElhinney, Elisabeth Kamphuis

Publikováno v: Biologicals. 40:369-381

Potency testing of most human and veterinary rabies vaccines requires vaccination of mice followed by a challenge test using an intracerebral injection of live rabies virus. NICEATM, ICCVAM, and their international partners organized a workshop to re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::21245106107495c333506a0d6d6216ef
https://doi.org/10.1016/j.biologicals.2012.07.005

Non-animal replacement methods for veterinary vaccine potency testing: state of the science and future directions

Autor: Brett Jones, Jodie Kulpa-Eddy, Vivian W. Doelling, Ivo Claassen, Glen Gifford, Jeffrey Galvin, Karen Brown, James Roth, Marlies Halder, Geetha Srinivas, Ralph Woodland, William S. Stokes, Richard Hill, Hans Draayer

Publikováno v: Procedia in Vaccinology

NICEATM and ICCVAM convened an international workshop to review the state of the science of human and veterinary vaccine potency and safety testing methods and to identify opportunities to advance new and improved methods that can further reduce, ref

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::157f7788a8195f999f1904827e201b2d
https://doi.org/10.1016/j.provac.2011.10.005

Improving animal welfare and reducing animal use for veterinary vaccine potency testing: state of the science and future directions

Autor: Glen Gifford, Ralph Woodland, William S. Stokes, Hans Draayer, Brett Jones, Ivo Claassen, Jeffrey Galvin, Jodie Kulpa-Eddy, Geetha Srinivas, Vivian W. Doelling, Karen Brown, Marlies Halder

Publikováno v: Procedia in Vaccinology. 5:84-105

Veterinary vaccines contribute to improved human and animal health and welfare by preventing diseases and deaths caused by a wide range of infectious agents. However, testing necessary to ensure vaccine effectiveness and safety can involve large numb

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afc25ac2e7560402c660b0460fb9b89e

A global initiative to refine acute inhalation studies through the use of ‘evident toxicity’ as an endpoint : Towards adoption of the fixed concentration procedure

Autor: Ian Indans, Jason Smedley, Graham W. Horgan, Anne Braun, Terry Kenny, Gary Wnorowski, Paul Smith, Brian S. Anderson, Ian Ragan, Hajime Kojima, William S. Stokes, Fiona Sewell, Robert Guest, Ngaire Dennison, David Griffiths, Warren Casey, Pilar Prieto, Ton van Huygevoort, Kyuhong Lee, Tim Marczylo, Tom Holmes

Publikováno v: Regulatory Toxicology and Pharmacology
Regulatory Toxicology and Pharmacology, Elsevier, 2015, 73 (3), pp.770-779. ⟨10.1016/j.yrtph.2015.10.018⟩

Acute inhalation studies are conducted in animals as part of chemical hazard identification and characterisation, including for classification and labelling purposes. Current accepted methods use death as an endpoint (OECD TG403 and TG436), whereas t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77030a14b4dce07859ac827d19793736
https://hal-ineris.archives-ouvertes.fr/ineris-01855133