Zobrazeno 1 - 10
of 105
pro vyhledávání: '"William S Kerwin"'
Autor:
Joyoti Dey, William S Kerwin, Marc O Grenley, Joseph R Casalini, Ilona Tretyak, Sally H Ditzler, Derek J Thirstrup, Jason P Frazier, Daniel W Pierce, Michael Carleton, Richard A Klinghoffer
Publikováno v:
PLoS ONE, Vol 11, Iss 6, p e0158617 (2016)
While advances in high-throughput screening have resulted in increased ability to identify synergistic anti-cancer drug combinations, validation of drug synergy in the in vivo setting and prioritization of combinations for clinical development remain
Externí odkaz:
https://doaj.org/article/3dfa9d0784154a92b30e5d49cad7c9c4
Autor:
Jinnan Wang, Maobin Guan, Kiyofumi Yamada, Daniel S Hippe, William S Kerwin, Chun Yuan, Peter Börnert, Xihai Zhao
Publikováno v:
PLoS ONE, Vol 11, Iss 2, p e0149130 (2016)
Simultaneous Non-contrast Angiography and intraPlaque hemorrhage (SNAP) technique was recently proposed for joint MRA and intraplaque hemorrhage (IPH) imaging. The purpose of this study is to validate SNAP's MRA performance in patients with suspected
Externí odkaz:
https://doaj.org/article/c70ba928bd0d48cf86e4ef290a032fa4
Autor:
Esben Laugesen, Pernille Høyem, Samuel Thrysoe, Esben Søvsø Szocska Hansen, Anders F. Stegmann Mikkelsen, William S. Kerwin, Per L. Poulsen, Troels K. Hansen, W. Yong Kim
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 7, Iss 16 (2018)
Background Ischemic stroke from carotid plaque embolism remains a major cause of morbidity in patients with type 2 diabetes mellitus (T2DM). However, the effect of early T2DM and obesity on carotid remodeling and plaque burden remains elusive. We ass
Externí odkaz:
https://doaj.org/article/ba3e45cd254243369e6671eeb167d2ac
Autor:
Jessica A. Bertout, Kimberly H.W. Sottero, Richard A. Klinghoffer, Jason Frazier, Howard J. Goodman, Matthew J. Thompson, Gary B. Deutsch, Daniel C. Ramirez, Joyoti Dey, Marc Grenley, Mee Young Lee, Kenneth R. Gundle, William S. Kerwin, Micah Ellison, Jessica L. Davis, Robert G. Maki, Seth M. Pollack, Emily Beirne
Publikováno v:
Clinical Cancer Research. 26:3958-3968
Purpose: A persistent issue in cancer drug development is the discordance between robust antitumor drug activity observed in laboratory models and the limited benefit frequently observed when patients are treated with the same agents in clinical tria
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0c1d6980abd02bcb1b9f58a80547b972
https://doi.org/10.1158/1078-0432.ccr-20-0614
https://doi.org/10.1158/1078-0432.ccr-20-0614
Autor:
Kate C. Gillespie, Thomas L. Deckwerth, Richard A. Klinghoffer, Joseph Casalini, Joyoti Dey, Edward F. Kleinman, Sally Ditzler, Marc Grenley, Emily Beirne, Chantel P. Dixon, Angela Merrell, Connor Burns, William S. Kerwin
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Scientific Reports
Scientific Reports
Aberrant regulation of BCL-2 family members enables evasion of apoptosis and tumor resistance to chemotherapy. BCL-2 and functionally redundant counterpart, MCL-1, are frequently over-expressed in high-risk diffuse large B-cell lymphoma (DLBCL). Whil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46350778d35faa88995b3d2c527bb77d
http://link.springer.com/article/10.1038/s41598-017-18368-w
http://link.springer.com/article/10.1038/s41598-017-18368-w
Publikováno v:
Seminars in Vascular Surgery. 30:54-61
The emergence of the concept of high-risk atherosclerotic plaque has led to considerable interest in noninvasive imaging techniques to identify high-risk features before clinical sequelae. For plaques in the carotid arteries, magnetic resonance imagi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e57ab3b3d736f52844adb29a0f77a64
https://doi.org/10.1053/j.semvascsurg.2017.04.009
https://doi.org/10.1053/j.semvascsurg.2017.04.009
Publikováno v:
Vessel Based Imaging Techniques ISBN: 9783030252489
Image processing plays a key role in vessel wall imaging. Vessel wall analysis typically requires multiple contrast-weighted imaging, image registration, and both qualitative and quantitative measurements to assess vessel wall status for disease. Ima
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::06a69ef21fd3922e4522baadddcc276c
https://doi.org/10.1007/978-3-030-25249-6_14
https://doi.org/10.1007/978-3-030-25249-6_14
Publikováno v:
Neuroimaging Clinics of North America. 26:13-28
Plaque imaging by MR imaging provides a wealth of information on the characteristics of individual plaque that may reveal vulnerability to rupture, likelihood of progression, or optimal treatment strategy. T1-weighted and T2-weighted images among oth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44896201e13c2cd126b6be6878fdd0ef
https://doi.org/10.1016/j.nic.2015.09.002
https://doi.org/10.1016/j.nic.2015.09.002
Autor:
Amy Wang, Jinnan Wang, Chun Yuan, William S. Kerwin, Daniel S. Hippe, Thomas S. Hatsukami, Jin Liu, Marina S. Ferguson, Niranjan Balu, Jie Sun
Publikováno v:
J Magn Reson Imaging
Background Presence of intraplaque hemorrhage (IPH) is a known risk factor for stroke and plaque progression. Accurate and reproducible measurement of IPH volume are required for further risk stratification. Purpose To develop a semiautomatic method
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b67a87b168337ef4d728db33057c734
https://pubmed.ncbi.nlm.nih.gov/30861249
https://pubmed.ncbi.nlm.nih.gov/30861249
Autor:
Ilona Tretyak, Richard A. Klinghoffer, William S. Kerwin, Marc Grenley, Sheng You, Derek Thirstrup, Beryl A. Hatton, Alicia Moreno-Gonzalez
Publikováno v:
Magnetic Resonance in Medicine. 76:946-952
Purpose To facilitate decision making in the oncology clinic, technologies have recently been developed to independently inject and assess multiple anticancer agents directly in a patient's tumor. To increase the flexibility of this approach beyond h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a16f407117e0a25dacddd879eb484d50
https://doi.org/10.1002/mrm.25978
https://doi.org/10.1002/mrm.25978