Zobrazeno 1 - 10
of 105
pro vyhledávání: '"William S Chen"'
Publikováno v:
Journal of Biological Engineering, Vol 18, Iss 1, Pp 1-13 (2024)
Abstract Adenosine triphosphate (ATP) assays have a faster turnaround time and higher sensitivity than traditional cultivation methods for microbial monitoring. Challenges implementing ATP testing include incompatibility with chlorine quenching agent
Externí odkaz:
https://doaj.org/article/a8af5ac2d1444444a135b784740be81c
Autor:
Kenneth Jung, Paea LePendu, William S Chen, Srinivasan V Iyer, Ben Readhead, Joel T Dudley, Nigam H Shah
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e89324 (2014)
Off-label drug use, defined as use of a drug in a manner that deviates from its approved use defined by the drug's FDA label, is problematic because such uses have not been evaluated for safety and efficacy. Studies estimate that 21% of prescriptions
Externí odkaz:
https://doaj.org/article/80dea625c4fb4e498a30e576c2453ec4
Autor:
Naohiro Kawamura, Fumitaka Kugimiya, Yasushi Oshima, Shinsuke Ohba, Toshiyuki Ikeda, Taku Saito, Yusuke Shinoda, Yosuke Kawasaki, Naoshi Ogata, Kazuto Hoshi, Toru Akiyama, William S Chen, Nissim Hay, Kazuyuki Tobe, Takashi Kadowaki, Yoshiaki Azuma, Sakae Tanaka, Kozo Nakamura, Ung-il Chung, Hiroshi Kawaguchi
Publikováno v:
PLoS ONE, Vol 2, Iss 10, p e1058 (2007)
Bone mass and turnover are maintained by the coordinated balance between bone formation by osteoblasts and bone resorption by osteoclasts, under regulation of many systemic and local factors. Phosphoinositide-dependent serine-threonine protein kinase
Externí odkaz:
https://doaj.org/article/b087c7a6b12e40778f05568f6ac44d6b
Autor:
Nicholas R. Rydzewski, Erik Peterson, Joshua M. Lang, Menggang Yu, S. Laura Chang, Martin Sjöström, Hamza Bakhtiar, Gefei Song, Kyle T. Helzer, Matthew L. Bootsma, William S. Chen, Raunak M. Shrestha, Meng Zhang, David A. Quigley, Rahul Aggarwal, Eric J. Small, Daniel R. Wahl, Felix Y. Feng, Shuang G. Zhao
Publikováno v:
npj Genomic Medicine, Vol 6, Iss 1, Pp 1-9 (2021)
Abstract We are now in an era of molecular medicine, where specific DNA alterations can be used to identify patients who will respond to specific drugs. However, there are only a handful of clinically used predictive biomarkers in oncology. Herein, w
Externí odkaz:
https://doaj.org/article/683460200e2546bd8518fb156fad7efa
Autor:
Rajdeep Das, Martin Sjöström, Raunak Shrestha, Christopher Yogodzinski, Emily A. Egusa, Lisa N. Chesner, William S. Chen, Jonathan Chou, Donna K. Dang, Jason T. Swinderman, Alex Ge, Junjie T. Hua, Shaheen Kabir, David A. Quigley, Eric J. Small, Alan Ashworth, Felix Y. Feng, Luke A. Gilbert
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
It is hypothesized that there are a number of tumor specific driver genes for metastatic prostate cancer. Here, the authors perform genome-wide CRISPRi screens and integrate these data with metastatic prostate cancer functional and clinical genomics
Externí odkaz:
https://doaj.org/article/fa65632946e846318209a6540b59b6ba
Autor:
Felix Y. Feng, Eric J. Small, Christopher A. Maher, Paul L. Nguyen, Daniel E. Spratt, Shruti Jolly, Edwin M. Posadas, Linda R. Duska, Elai Davicioni, Yang Liu, Ewan A. Gibb, Brandon A. Mahal, Travis J. Barnard, Ha X. Dang, David A. Quigley, Jonathan Chou, Scott A. Tomlins, S. Laura Chang, Rajdeep Das, William S. Chen, Shuang G. Zhao
Supplemental Tables 1-7
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bae6906bc2fa43dcb6bd5bc6635a5fb8
https://doi.org/10.1158/1078-0432.22471452.v1
https://doi.org/10.1158/1078-0432.22471452.v1
Autor:
Joshi J. Alumkal, Zheng Xia, Eric J. Small, Felix Y. Feng, Joshua M. Stuart, Alana S. Weinstein, Jack Youngren, William S. Chen, Adam Foye, David A. Quigley, Rahul R. Aggarwal, Jiaoti Huang, George V. Thomas, Tomasz M. Beer, Martin Gleave, Primo Lara, Christopher P. Evans, Matthew Rettig, Robert Evan Reiter, Joshua A. Urrutia, Eric Lu, Duanchen Sun, Xiangnan Guan
Figure S1 shows that copy number alterations of well-described prostate cancer tumor suppressor genes are not different between enzalutamide-naïve and -resistant tumors.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80b5f097f4baec4e0f37a6670b89656a
https://doi.org/10.1158/1078-0432.22476762
https://doi.org/10.1158/1078-0432.22476762
Autor:
Felix Y. Feng, Eric J. Small, Christopher A. Maher, Paul L. Nguyen, Daniel E. Spratt, Shruti Jolly, Edwin M. Posadas, Linda R. Duska, Elai Davicioni, Yang Liu, Ewan A. Gibb, Brandon A. Mahal, Travis J. Barnard, Ha X. Dang, David A. Quigley, Jonathan Chou, Scott A. Tomlins, S. Laura Chang, Rajdeep Das, William S. Chen, Shuang G. Zhao
Purpose:Carcinomas originate from epithelial tissues, which have apical (luminal) and basal orientations. The degree of luminal versus basal differentiation in cancer has been shown to be biologically important in some carcinomas and impacts treatmen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36e7530b6b2bb3f86ab74fca6019c0ae
https://doi.org/10.1158/1078-0432.c.6527901.v1
https://doi.org/10.1158/1078-0432.c.6527901.v1
Autor:
Felix Y. Feng, John C. Shon, David Y. Oh, Antoni Ribas, Patrick S. Daugherty, Eric J. Small, Rahul Aggarwal, Alan Ashworth, Joshi J. Alumkal, Robert E. Reiter, Kim N. Chi, Primo Lara, Christopher P. Evans, Martin Gleave, Matthew Rettig, Tomasz M. Beer, Jonathan Chou, David A. Quigley, Martin Sjöström, Shuang G. Zhao, Meng Zhang, Ivan Perez Garcilazo, Ignacio Baselga Carretero, Adam Foye, Minlu Zhang, Raunak Shrestha, Agustin Vega-Crespo, Kathy Kamath, Rebecca Waitz, Winston A. Haynes, William S. Chen
Purpose:Autoantibody responses in cancer are of great interest, as they may be concordant with T-cell responses to cancer antigens or predictive of response to cancer immunotherapies. Thus, we sought to characterize the antibody landscape of metastat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5af44d37d107e4ca4b490fcf564a77c3
https://doi.org/10.1158/1078-0432.c.6529490
https://doi.org/10.1158/1078-0432.c.6529490
Autor:
Felix Y. Feng, Paul L. Nguyen, Eric J. Small, Karen E. Knudsen, Christopher A. Maher, Philip W. Kantoff, Timothy R. Rebbeck, Elai Davicioni, Ting Wei, David A. Quigley, Brandon A. Mahal, Yang Liu, Shuang G. Zhao, Mohammed Alshalalfa, William S. Chen
Purpose:Rb-pathway disruption is of great clinical interest, as it has been shown to predict outcomes in multiple cancers. We sought to develop a transcriptomic signature for detecting biallelic RB1 loss (RBS) that could be used to assess the clinica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9db79fe7f82d63e89349907ab771206
https://doi.org/10.1158/1078-0432.c.6528218
https://doi.org/10.1158/1078-0432.c.6528218