Výsledky vyhledávání - "William S Blaner"

Akademický článek

Alcohol induced hepatic retinoid depletion is associated with the induction of multiple retinoid catabolizing cytochrome P450 enzymes.

Autor: Afroza Ferdouse, Rishi R Agrawal, Madeleine A Gao, Hongfeng Jiang, William S Blaner, Robin D Clugston

Publikováno v: PLoS ONE, Vol 17, Iss 1, p e0261675 (2022)

Chronic alcohol consumption leads to a spectrum of liver disease that is associated with significant global mortality and morbidity. Alcohol is known to deplete hepatic vitamin A content, which has been linked to the pathogenesis of alcoholic liver d

Externí odkaz: https://doaj.org/article/c3ccee62e41848cdb2c8d3637bc2286e

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Akademický článek

Metabolic changes in skin caused by Scd1 deficiency: a focus on retinol metabolism.

Autor: Matthew T Flowers, Chad M Paton, Sheila M O'Byrne, Kevin Schiesser, John A Dawson, William S Blaner, Christina Kendziorski, James M Ntambi

Publikováno v: PLoS ONE, Vol 6, Iss 5, p e19734 (2011)

We previously reported that mice with skin-specific deletion of stearoyl-CoA desaturase-1 (Scd1) recapitulated the skin phenotype and hypermetabolism observed in mice with a whole-body deletion of Scd1. In this study, we first performed a diet-induce

Externí odkaz: https://doaj.org/article/e0bea49653f9423780a520cbd6abd384

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Akademický článek

Retinoid-induced expression and activity of an immediate early tumor suppressor gene in vascular smooth muscle cells.

Autor: Jeffrey W Streb, Xiaochun Long, Ting-Hein Lee, Qiang Sun, Chad M Kitchen, Mary A Georger, Orazio J Slivano, William S Blaner, Daniel W Carr, Irwin H Gelman, Joseph M Miano

Publikováno v: PLoS ONE, Vol 6, Iss 4, p e18538 (2011)

Retinoids are used clinically to treat a number of hyper-proliferative disorders and have been shown in experimental animals to attenuate vascular occlusive diseases, presumably through nuclear receptors bound to retinoic acid response elements (RARE

Externí odkaz: https://doaj.org/article/140e7afc289a4e2198d80a2ce8f33b11

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Akademický článek

Distinct populations of hepatic stellate cells in the mouse liver have different capacities for retinoid and lipid storage.

Autor: Diana N D'Ambrosio, José L Walewski, Robin D Clugston, Paul D Berk, Richard A Rippe, William S Blaner

Publikováno v: PLoS ONE, Vol 6, Iss 9, p e24993 (2011)

Hepatic stellate cell (HSC) lipid droplets are specialized organelles for the storage of retinoid, accounting for 50-60% of all retinoid present in the body. When HSCs activate, retinyl ester levels progressively decrease and the lipid droplets are l

Externí odkaz: https://doaj.org/article/2880848f92ba4eed9f50e0a54e4afe1b

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Akademický článek

Retinoids stored locally in the lung are required to attenuate the severity of acute lung injury in male mice

Autor: Igor O. Shmarakov, Galina A. Gusarova, Mohammad N. Islam, María Marhuenda-Muñoz, Jahar Bhattacharya, William S. Blaner

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-21 (2023)

Retinoids can act as transcriptional regulators to regulate cell proliferation, differentiation, and other processes. Here, the authors show that uncompromised vitamin A (retinoid) metabolism and signaling in alveolar lipofibroblasts, endothelial and

Externí odkaz: https://doaj.org/article/1ee5b3c97a3e4824a8aa000e40e41209

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Akademický článek

Control by the brain of vitamin A homeostasis

Autor: Peter I. Imoesi, Cristian M. Olarte-Sánchez, Lorenzo Croce, William S. Blaner, Peter J. Morgan, Lora Heisler, Peter McCaffery

Publikováno v: iScience, Vol 26, Iss 8, Pp 107373- (2023)

Summary: Vitamin A is a micronutrient essential for vertebrate animals maintained in homeostatic balance in the body; however, little is known about the control of this balance. This study investigated whether the hypothalamus, a key integrative brai

Externí odkaz: https://doaj.org/article/ebf8a6c142a94907b312a1ef03411d65

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Akademický článek

Design and Rationale the SCAN‐MP (Screening for Cardiac Amyloidosis With Nuclear Imaging in Minority Populations) Study

Autor: Frederick L. Ruberg, William S. Blaner, Codruta Chiuzan, Lawreen H. Connors, Andrew J. Einstein, Denise Fine, Stephen Helmke, Damian Kurian, Shivda Pandey, Farbod Raiszadeh, Carlos Rodriguez, Natalia Sabogal, Sergio Teruya, Morgan Winburn, Wendy K. Chung, Elizabeth Cohn, Edward J. Miller, Jeffery W. Kelly, Mathew S. Maurer

Publikováno v: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 12, Iss 8 (2023)

Background Transthyretin amyloid cardiomyopathy (ATTR‐CM) is an important cause of heart failure in older individuals. Misfolding and deposition of transthyretin or prealbumin protein causes ATTR‐CM in the context of a normal (wild‐type) or var

Externí odkaz: https://doaj.org/article/b9c1a2b8e2904079929f27ab244cfe0a

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Akademický článek

Vitamin A regulates tissue-specific organ remodeling in diet-induced obesity independent of mitochondrial function

Autor: Ivanna Shymotiuk, Natali Froese, Christopher Werlein, Lea Naasner, Malgorzata Szaroszyk, Mark P. Kühnel, Danny D. Jonigk, William S. Blaner, Adam R. Wende, E. Dale Abel, Johann Bauersachs, Christian Riehle

Publikováno v: Frontiers in Endocrinology, Vol 14 (2023)

BackgroundPerturbed mitochondrial energetics and vitamin A (VitA) metabolism are associated with the pathogenesis of diet-induced obesity (DIO) and type 2 diabetes (T2D).MethodsTo test the hypothesis that VitA regulates tissue-specific mitochondrial

Externí odkaz: https://doaj.org/article/a7b8334c47324bfbb1423d724828512f

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