Lenzilumab in hospitalised patients with COVID-19 pneumonia (LIVE-AIR): a phase 3, randomised, placebo-controlled trial

Autor: Juan Pulido, Michael Boger, John Hollingsworth, Homero Paniagua, Lucas GuimarÃes, Lisa Davidson, Victor Matheus Rolim de Souzafrom, Ana Elizabeth G. Maldonado, Colleen F. Kelley, Ricardo Diaz, Caitlin Moran, Jennifer Fulton, Ana Carolina M. Beheregaray, Valeria Telles, Khang Vo, Cameron Durrant, Omar Ahmed, Alpesh Amin, Daniel Barbaro, EstevÃo Figueiredo, David Weinrib, Noah Wald-Dickler, Daniel Wagner de Castro Lima Santos, Rebeca C. Lacerda Garcia, Brian Metzger, Paulo Ferreira, Andrew Miller, Marina Andrade Lima, Wilfred Onyia, William S Aronstein, Chrisoula Politis, Maqsood Alam, Celso Silva, Ana Maria T. Ortiz, Julia Minghini, Gualter CanÇado, Charles D. Burger, Mindy Sampson, Martin Cearras, Anne Frosch, Maysa B. Alves, Roy Poblete, Felipe Dal Pizzol, Carmen Polito, TÁcito do Nascimento JÁcome, Adilson Joaquim Westheimer Cavalcante, John Burk, Camila Anton, Eveline Pipolo Milan, Cristiane Ritter, Vincent C. Marconi, Dale Chappell, Loni Dorigo, Ricardo Albaneze, Renata Bezerra Onofre, Carlos del Rio, Miki Watanabe, Joshua Berg, Claudia R. Libertin, Janine Soares de Castro, Seife Yohannes, Juvencio José Duailibe Furtado, Linda Sher, May M. Lee, Robert Orenstein, Obinna Okoye, Linh Ngo, Jeffrey Lennox, Richard Zuckerman, Stephanie Strollo, Lakshmi Sambathkumar, Jason Sniffen, Paula Pietrobom, Kiran Gajurel, Lewis McCurdy, Matheus José Barbosa Moreira, Subarna Biswas, Valeria Cantos, Ana Caroline Iglessias, Jason Baker, Leopoldo T. Trevelin, John Gharbin, Victor Barreto Garcia, Marcelo B. Vinhas, Kleber Luz, Henrikki Antila, Fernando Carvalho Neuenschwander, Zelalem Temesgen, Cheryl McDonald, Sara Zulfigar, Michael Leonard, Fabiano Ramos, Gabrielle Chappell, William Gill, Martti Anton Antila, Anandi Sheth, Meghan Lewis, Sheetal Kandiah, Michael Bowdish, Lanny Hsieh, Paulina Rebolledo, Francini Correa, Chaitanya Mandapakala, Stuart McDonald, Natalia Bacellar, Zainab Shahid, Victoria M Catterson, Matthew Robinson, Rebeca Brugnolli, Richard Lee, Marina de A. R. Da Silva, Amay Parikh, Anup Patel, Gustavo Araujo, Andrew D. Badley, Caroline Uber Ghisi, Roberto Patron, Douglass Hutcheon, Marianna M. Lago, Christopher Polk, Nestor Quezada, Lionel Lewis, Marina Salgado Miranda, Lydia Lam

Publikováno v: The Lancet. Respiratory Medicine

Summary Background The pathophysiology of COVID-19 includes immune-mediated hyperinflammation, which could potentially lead to respiratory failure and death. Granulocyte-macrophage colony-stimulating factor (GM-CSF) is among cytokines that contribute

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5365a062e325727cdb2b2d6c7a807e17
https://doi.org/10.1016/s2213-2600(21)00494-x

Dose Escalation Study of the Safety, Tolerability, and Pharmacokinetics of Nemonoxacin (TG-873870), a Novel Potent Broad-Spectrum Nonfluorinated Quinolone, in Healthy Volunteers

Autor: David T. Chung, Cheng-Yuan Tsai, Ching-Hung Hsu, Barbara Kuzmak, Luke Lin, Li-Wen Chang, Funmi Ajayi, Robert A. Lyon, William S. Aronstein

Publikováno v: Antimicrobial Agents and Chemotherapy. 54:405-410

Nemonoxacin (TG-873870) is a novel nonfluorinated quinolone with potent broad-spectrum activity against Gram-positive and Gram-negative pathogens, including methicillin-resistant Staphylococcus aureus , penicillin- and quinolone-resistant Streptococc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbcc58f8f959cadf9ebf088e40305555
https://doi.org/10.1128/aac.00682-09

QT/QTc Prolongation in Placebo-Treated Subjects: a PhRMA Collaborative Data Analysis

Autor: Margarida Geraldes, Georg Ferber, Marilyn A. Agin, Philip T. Sager, William S. Aronstein, Charles Locke

Publikováno v: Journal of Biopharmaceutical Statistics. 18:408-426

In an ongoing effort to try to understand the variability of QT/QTc data and determine how that variability would affect the design, analysis, and conclusions drawn from data collected in thorough QT/QTc studies, five Pharmaceutical Research and Manu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1084a891f6d5eae961d874cf05283847
https://doi.org/10.1080/10543400801992962

Efficacy of Darifenacin in Patients with Varying Baseline Symptom Severity

Autor: Roger R Dmochowski, Yodit Seifu, William S Aronstein, Andrea Larson-Peters

Publikováno v: UroToday International Journal.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0314ba38e8a39e1e8c25e51f5cc26b99
https://doi.org/10.3834/uij.1944-5784.2009.06.16

Development of musculoskeletal toxicity without clear benefit after administration of PG-116800, a matrix metalloproteinase inhibitor, to patients with knee osteoarthritis: a randomized, 12-month, double-blind, placebo-controlled study

Autor: Piotr Krzeski, Gary A Cline, Géza Bálint, Robert A. Lyon, William S. Aronstein, John F. Beary, Tim D. Spector, Karen J Stoner, Chris Buckland-Wright

Publikováno v: Arthritis Research & Therapy

We performed a randomized, double-blind, placebo-controlled, multicenter, parallel-group, dose-response study of the efficacy and safety of the oral administration of PG-116800, a matrix metalloproteinase (MMP) inhibitor, in patients with mild to mod

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6853898930e7e6c8a64facaa96817d04
https://doi.org/10.1186/ar2315