Zobrazeno 1 - 10
of 384
pro vyhledávání: '"William S, Sly"'
Publikováno v:
The Journal of Physiology. 601:257-274
Carbonic anhydrase V (CA V), a mitochondrial enzyme, was first isolated from guinea pig liver and subsequently identified in mice and humans. Later, studies revealed that the mouse genome contains two mitochondrial CA sequences, named Car5A and Car5B
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04fb95f9e7e1e695b78fc6df98dee3c1
https://doi.org/10.1113/jp283579
https://doi.org/10.1113/jp283579
Autor:
Jessica Schmiesing, Stephan Storch, Ann-Cathrin Dörfler, Michaela Schweizer, Georgia Makrypidi-Fraune, Melanie Thelen, Marc Sylvester, Volkmar Gieselmann, Catherine Meyer-Schwesinger, Friedrich Koch-Nolte, Henning Tidow, Chris Mühlhausen, Abdul Waheed, William S. Sly, Thomas Braulke
Publikováno v:
Cell Reports, Vol 24, Iss 11, Pp 2946-2956 (2018)
Summary: Lysine glutarylation (Kglu) of mitochondrial proteins is associated with glutaryl-CoA dehydrogenase (GCDH) deficiency, which impairs lysine/tryptophan degradation and causes destruction of striatal neurons during catabolic crisis with subseq
Externí odkaz:
https://doaj.org/article/b3476a6f49174f2f967f25a8a25f0543
Autor:
Roberto Giugliani, Uma Ramaswami, Anna Tylki‐Szymańska, Barbara K. Burton, James Davison, Chris Hendriksz, Young Bae Sohn, Paul Harmatz, Erin Jozwiak, Torayuki Okuyama, Adriana M. Montaño, William S. Sly, Barbara Triggs‐Raine, Promita Ghosh, Marvin Natowicz
Publikováno v:
Lysosomal Storage Disorders. :155-193
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bbc6ce87b2f7cff0874dcc7b0991eaa6
https://doi.org/10.1002/9781119697312.ch16
https://doi.org/10.1002/9781119697312.ch16
Autor:
Adrian L. Harris, Pawel Swietach, Richard D. Vaughan-Jones, William S. Sly, Kevin Gatter, Cameron Snell, Russell Leek, Helen Turley, Ioanna Ledaki, Ji-liang Li, Simon Wigfield, Shalini Patiar, Alan McIntyre
(72 KB)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fdc789bf64d005a58a39783951b9ca3
https://doi.org/10.1158/1078-0432.22443911
https://doi.org/10.1158/1078-0432.22443911
Autor:
Adrian L. Harris, Pawel Swietach, Richard D. Vaughan-Jones, William S. Sly, Kevin Gatter, Cameron Snell, Russell Leek, Helen Turley, Ioanna Ledaki, Ji-liang Li, Simon Wigfield, Shalini Patiar, Alan McIntyre
Purpose: Bevacizumab, an anti-VEGFA antibody, inhibits the developing vasculature of tumors, but resistance is common. Antiangiogenic therapy induces hypoxia and we observed increased expression of hypoxia-regulated genes, including carbonic anhydras
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f44ccc35304b124147cf4893c476a8a3
https://doi.org/10.1158/1078-0432.c.6520010.v1
https://doi.org/10.1158/1078-0432.c.6520010.v1
Autor:
Adrian L. Harris, Pawel Swietach, Richard D. Vaughan-Jones, William S. Sly, Kevin Gatter, Cameron Snell, Russell Leek, Helen Turley, Ioanna Ledaki, Ji-liang Li, Simon Wigfield, Shalini Patiar, Alan McIntyre
(1543 KB) - Analysis of the viable tumour volume at the first endpoint of the HCT116 and HT29 xenograft and spheroid experiments revealed that the CAIX expressors had increased viable tissue in HCT116 (A) xenografts (40% more viable tissue at day 14,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::046b047b2dfb1cebd9a0eb2a4a3ce9fa
https://doi.org/10.1158/1078-0432.22443923.v1
https://doi.org/10.1158/1078-0432.22443923.v1
Autor:
Adrian L. Harris, Pawel Swietach, Richard D. Vaughan-Jones, William S. Sly, Kevin Gatter, Cameron Snell, Russell Leek, Helen Turley, Ioanna Ledaki, Ji-liang Li, Simon Wigfield, Shalini Patiar, Alan McIntyre
(244 KB) - Bar chart of scoring of immunohistochemistry and representative immunohistochemistry images of HT29 shCA9 and EV xenografts with and without Bevacizumab treatment. CAIX expression (**p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::234dcc6a320157bc675025f7a876c7de
https://doi.org/10.1158/1078-0432.22443917
https://doi.org/10.1158/1078-0432.22443917
Autor:
Adrian L. Harris, Pawel Swietach, Richard D. Vaughan-Jones, William S. Sly, Kevin Gatter, Cameron Snell, Russell Leek, Helen Turley, Ioanna Ledaki, Ji-liang Li, Simon Wigfield, Shalini Patiar, Alan McIntyre
(8129 KB) - Bar chart of scoring of immunohistochemistry and representative immunohistochemistry images of HT29 xenografts with and without acetazolomide and/or Bevacizumab treatment. CAIX expression (vehicle (DMSO) *p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12b78679de9bfe3d82a5e2e8daaa850b
https://doi.org/10.1158/1078-0432.22443914.v1
https://doi.org/10.1158/1078-0432.22443914.v1
Autor:
Adrian L. Harris, Pawel Swietach, Richard D. Vaughan-Jones, William S. Sly, Kevin Gatter, Cameron Snell, Russell Leek, Helen Turley, Ioanna Ledaki, Ji-liang Li, Simon Wigfield, Shalini Patiar, Alan McIntyre
(1056 KB) - Analysis of CA9 RNA expression in U87 xenografts untreated and with chronic Bevacizumab treatment. Bevacizumab treatement increased CA9 expression (***p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c7449a2b7910b2df8a92e5174d66b2f
https://doi.org/10.1158/1078-0432.22443920.v1
https://doi.org/10.1158/1078-0432.22443920.v1
Autor:
Ashok Aspatwar, Martti E. E. Tolvanen, Harlan Barker, Leo Syrjänen, Susanna Valanne, Sami Purmonen, Abdul Waheed, William S. Sly, Seppo Parkkila
Publikováno v:
Physiological reviews. 102(3)
During the past three decades, mice, zebrafish, fruit flies, and Caenorhabditis elegans have been the primary model organisms used for the study of various biological phenomena. These models have also been adopted and developed to investigate the phy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53b9633c4f133256e15dc670e51a1a90
https://pubmed.ncbi.nlm.nih.gov/35166161
https://pubmed.ncbi.nlm.nih.gov/35166161