Zobrazeno 1 - 10
of 261
pro vyhledávání: '"William Ritchie"'
Autor:
Claudio Lorenzi, Sylvain Barriere, Katharina Arnold, Reini F. Luco, Andrew J. Oldfield, William Ritchie
Publikováno v:
Genome Biology, Vol 22, Iss 1, Pp 1-13 (2021)
Abstract Accurate quantification and detection of intron retention levels require specialized software. Building on our previous software, we create a suite of tools called IRFinder-S, to analyze and explore intron retention events in multiple sample
Externí odkaz:
https://doaj.org/article/6aefeefa1b79441d91cb3a8aab7fe382
Autor:
Jean-Philippe Villemin, Claudio Lorenzi, Marie-Sarah Cabrillac, Andrew Oldfield, William Ritchie, Reini F. Luco
Publikováno v:
BMC Biology, Vol 19, Iss 1, Pp 1-19 (2021)
Abstract Background Breast cancer is amongst the 10 first causes of death in women worldwide. Around 20% of patients are misdiagnosed leading to early metastasis, resistance to treatment and relapse. Many clinical and gene expression profiles have be
Externí odkaz:
https://doaj.org/article/4eaadcae7c514907b1f1dfa56b8108c6
Autor:
Claudio Lorenzi, Sylvain Barriere, Jean-Philippe Villemin, Laureline Dejardin Bretones, Alban Mancheron, William Ritchie
Publikováno v:
Genome Biology, Vol 21, Iss 1, Pp 1-19 (2020)
Abstract iMOKA (interactive multi-objective k-mer analysis) is a software that enables comprehensive analysis of sequencing data from large cohorts to generate robust classification models or explore specific genetic elements associated with disease
Externí odkaz:
https://doaj.org/article/657a9813fae846e0823e869ad4951436
Autor:
Lucile Broseus, William Ritchie
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 18, Iss , Pp 501-508 (2020)
Intron retention (IR) occurs when an intron is transcribed into pre-mRNA and remains in the final mRNA. An increasing body of literature has demonstrated a major role for IR in numerous biological functions and in disease. Here we give an overview of
Externí odkaz:
https://doaj.org/article/fd21c79c38904c859e562c1fa45cc28f
Autor:
Megha Rajasekhar, Ulf Schmitz, Stephane Flamant, Justin J.-L. Wong, Charles G. Bailey, William Ritchie, Jeff Holst, John E. J. Rasko
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-15 (2018)
Abstract Myelopoiesis involves differentiation of hematopoietic stem cells to cellular populations that are restricted in their self-renewal capacity, beginning with the common myeloid progenitor (CMP) and leading to mature cells including monocytes
Externí odkaz:
https://doaj.org/article/5130f8e3f39c40e099172e258a4f2129
Autor:
Ulf Schmitz, Natalia Pinello, Fangzhi Jia, Sultan Alasmari, William Ritchie, Maria-Cristina Keightley, Shaniko Shini, Graham J. Lieschke, Justin J-L Wong, John E. J. Rasko
Publikováno v:
Genome Biology, Vol 18, Iss 1, Pp 1-15 (2017)
Abstract Background While intron retention (IR) is now widely accepted as an important mechanism of mammalian gene expression control, it remains the least studied form of alternative splicing. To delineate conserved features of IR, we performed an e
Externí odkaz:
https://doaj.org/article/9b968d71e3be43b4a85b98ccc47c942e
Autor:
Justin J. -L. Wong, Dadi Gao, Trung V. Nguyen, Chau-To Kwok, Michelle van Geldermalsen, Rob Middleton, Natalia Pinello, Annora Thoeng, Rajini Nagarajah, Jeff Holst, William Ritchie, John E. J. Rasko
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Intron retention is a conserved mechanism that controls gene expression but its regulation is poorly understood. Here, the authors provide evidence that DNA methylation regulates intron retention and find reduced MeCP2 occupancy and splicing factor r
Externí odkaz:
https://doaj.org/article/119a506ca1a641cd82f6def9763f7671
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 5, Iss C (2016)
The regulation of function of endothelial cell–cell junctions is fundamental in sustaining vascular integrity. The polycistronic microRNA (miR) complexes containing miR-23a-27a-24-2, and 23b-27b-24-1 are predicted to target the majority of major en
Externí odkaz:
https://doaj.org/article/d5ce49bcb71c46cca8edb4ddd75dc84c
Autor:
David G Hancock, Elena Shklovskaya, Thomas V Guy, Reza Falsafi, Chris D Fjell, William Ritchie, Robert E W Hancock, Barbara Fazekas de St Groth
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e100613 (2014)
Dendritic cells (DCs) are critical for regulating CD4 and CD8 T cell immunity, controlling Th1, Th2, and Th17 commitment, generating inducible Tregs, and mediating tolerance. It is believed that distinct DC subsets have evolved to control these diffe
Externí odkaz:
https://doaj.org/article/117bf5d8a4c744028ff45d77176fdb29
Autor:
Richard D Bagnall, Tatiana Tsoutsman, Rhian E Shephard, William Ritchie, Christopher Semsarian
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e44744 (2012)
MicroRNAs (miRNAs) regulate post-transcriptional gene expression during development and disease. We have determined the miRNA expression levels of early- and end-stage hypertrophic cardiomyopathy (HCM) in a severe, transgenic mouse model of the disea
Externí odkaz:
https://doaj.org/article/54c9e277339248f1b3d06f906e6953ef