Zobrazeno 1 - 8
of 8
pro vyhledávání: '"William Reiley"'
Autor:
Minying Zhang, Wei Jin, Ato Wright, Emmanuel M. Paul, Geetha R. Babu, William Reiley, Jun You, Mikyoung Chang, Andrew J. Lee, Shao Cong Sun
Publikováno v:
Journal of Clinical Investigation. 118:1858-1866
Osteoclastogenesis is a tightly regulated biological process, and deregulation can lead to severe bone disorders such as osteoporosis. The regulation of osteoclastic signaling is incompletely understood, but ubiquitination of TNF receptor–associate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4177f466277adcfad24af612867abdd
https://doi.org/10.1172/jci34257
https://doi.org/10.1172/jci34257
Autor:
William Reiley, Minying Zhang, Xuefeng Wu, Eric F. Tewalt, Christopher C. Norbury, Timothy O. Leonard, Ato Wright, Wei Jin, Shao Cong Sun, Andrew J. Lee, Leo R. Fitzpatrick
Publikováno v:
The Journal of Experimental Medicine
The deubiquitinating enzyme CYLD has recently been implicated in the regulation of signal transduction, but its physiological function and mechanism of action are still elusive. In this study, we show that CYLD plays a pivotal role in regulating T ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e2a777c38ed80b33e2a9561eff811cc
https://doi.org/10.1084/jem.20062694
https://doi.org/10.1084/jem.20062694
Autor:
Minying Zhang, Ato Wright, Wei Jin, William Reiley, Andrew J. Lee, Shao Cong Sun, Mikyoung Chang
Publikováno v:
Developmental cell. 13(5)
Spermatogenesis involves an early wave of germ cell apoptosis, which is required for maintaining the balance between germ cells and supporting Sertoli cells. However, the signaling mechanism regulating this apoptotic event is poorly defined. Here we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57b2c8d4a2ba2472cf3c389010403626
https://pubmed.ncbi.nlm.nih.gov/17981127
https://pubmed.ncbi.nlm.nih.gov/17981127
Autor:
Mandy K. Losiewicz, Christopher C. Norbury, Keri B. Donohue, Wei Jin, Minying Zhang, William Reiley, Shao Cong Sun
Publikováno v:
Nature immunology. 7(4)
T cell receptor signaling is essential for the generation and maturation of T lymphocyte precursors. Here we identify the deubiquitinating enzyme CYLD as a positive regulator of proximal T cell receptor signaling in thymocytes. CYLD physically intera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a42d98e38c28c7ef91fac1b5d8039d90
https://pubmed.ncbi.nlm.nih.gov/16550202
https://pubmed.ncbi.nlm.nih.gov/16550202
Publikováno v:
The Journal of biological chemistry. 280(11)
BAFF receptor (BAFFR) is a member of the TNF receptor (TNFR) superfamily that regulates the survival and maturation of B cells. BAFFR exerts its signaling function by inducing activation of NF-kappaB, although the underlying mechanism has not been we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80f740ea4d40f7a49f05e4de77af7618
https://pubmed.ncbi.nlm.nih.gov/15644327
https://pubmed.ncbi.nlm.nih.gov/15644327
Publikováno v:
The Journal of biological chemistry. 279(53)
CYLD is a tumor suppressor that is mutated in familial cylindromatosis, an autosomal dominant predisposition to multiple tumors of the skin appendages. Recent studies suggest that transfected CYLD has deubiquitinating enzyme activity and inhibits the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4588ff14d054ceb64831faabe77ff84
https://pubmed.ncbi.nlm.nih.gov/15496400
https://pubmed.ncbi.nlm.nih.gov/15496400
Publikováno v:
Molecular and cellular biology. 24(13)
IkappaB kinase (IKK), a key regulator of immune and inflammatory responses, is known as an effector kinase mediating activation of the transcription factor NF-kappaB. Whether IKK also participates in other signaling events is not known. Here we show
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7df9c2bf987c95fbd82479805ec882b6
https://pubmed.ncbi.nlm.nih.gov/15199157
https://pubmed.ncbi.nlm.nih.gov/15199157
Autor:
Jacob Kohlmeier, William Reiley, Georgia Perona-Wright, Michael Freeman, Yager Eric, Lisa Connor, Erik Brincks, Tres Cookenham, Alan Roberts, Claire Burkum, Gary Winslow, Marcia Blackman, Markus Mohrs, David Woodland
Publikováno v:
The Journal of Immunology. 186:150.3-150.3
The development of T cell memory from naïve precursors is a complex process influenced by molecular cues received during T cell activation and differentiation. In the present study, we describe a novel role for the chemokine receptors CCR5 and CXCR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::30c3723e1bea5009ec7fa45a11d42c89
https://doi.org/10.4049/jimmunol.186.supp.150.3
https://doi.org/10.4049/jimmunol.186.supp.150.3