Zobrazeno 1 - 10
of 506
pro vyhledávání: '"William R. Wilson"'
Publikováno v:
Journal of Vascular Surgery Cases and Innovative Techniques, Vol 10, Iss 3, Pp 101460- (2024)
Free-floating aortic mural thrombus in the minimally diseased or nonaneurysmal aorta is a rare, clinically significant source of peripheral embolism. We describe a 41-year-old woman with a history of left brachial thromboembolectomy who presented aty
Externí odkaz:
https://doaj.org/article/9d9dd500c4fd43cb9c4af99e0ee6b47d
Autor:
Stephen M.F. Jamieson, Peter Tsai, Maria K. Kondratyev, Pratha Budhani, Arthur Liu, Neil N. Senzer, E. Gabriela Chiorean, Shadia I. Jalal, John J. Nemunaitis, Dennis Kee, Avik Shome, Way W. Wong, Dan Li, Nooriyah Poonawala-Lohani, Purvi M. Kakadia, Nicholas S. Knowlton, Courtney R.H. Lynch, Cho R. Hong, Tet Woo Lee, Reidar A. Grénman, Laura Caporiccio, Trevor D. McKee, Mark Zaidi, Sehrish Butt, Andrew M.J. Macann, Nicholas P. McIvor, John M. Chaplin, Kevin O. Hicks, Stefan K. Bohlander, Bradly G. Wouters, Charles P. Hart, Cristin G. Print, William R. Wilson, Michael A. Curran, Francis W. Hunter
Publikováno v:
JCI Insight, Vol 8, Iss 4 (2023)
Externí odkaz:
https://doaj.org/article/b8265d5c0ed44e2583f6823d2b9a7cc0
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 21, Iss 2, Pp 159-171 (2019)
Tumor hypoxia contributes to resistance to anticancer therapies. Hypoxia-activated prodrugs (HAPs) selectively target hypoxic cells and their activity can extend to well-oxygenated areas of tumors via diffusion of active metabolites. This type of bys
Externí odkaz:
https://doaj.org/article/53e75c1e4b27467093f27e07ff59634b
Autor:
Cho R. Hong, Gib Bogle, Jingli Wang, Kashyap Patel, Frederik B. Pruijn, William R. Wilson, Kevin O. Hicks
Publikováno v:
Frontiers in Pharmacology, Vol 9 (2018)
Intra-tumor heterogeneity represents a major barrier to anti-cancer therapies. One strategy to minimize this limitation relies on bystander effects via diffusion of cytotoxins from targeted cells. Hypoxia-activated prodrugs (HAPs) have the potential
Externí odkaz:
https://doaj.org/article/764b9ed66dd64296903affcf0c72e274
Autor:
Chris P. Guise, Maria R. Abbattista, Robert F. Anderson, Dan Li, Rana Taghipouran, Angela Tsai, Su Jung Lee, Jeff B. Smaill, William A. Denny, Michael P. Hay, William R. Wilson, Kevin O. Hicks, Adam V. Patterson
Publikováno v:
Molecules, Vol 25, Iss 21, p 4888 (2020)
Hypoxia is an adverse prognostic feature of solid cancers that may be overcome with hypoxia-activated prodrugs (HAPs). Tirapazamine (TPZ) is a HAP which has undergone extensive clinical evaluation in this context and stimulated development of optimiz
Externí odkaz:
https://doaj.org/article/5febd59fbfbd4a7e9055143bd569de28
Autor:
Yongchuan Gu, Tony T.-A. Chang, Jingli Wang, Jagdish K. Jaiswal, David Edwards, Noel J. Downes, H. D. Sarath Liyanage, Courtney R. H. Lynch, Frederik B. Pruijn, Anthony J. R. Hickey, Michael P. Hay, William R. Wilson, Kevin O. Hicks
Publikováno v:
Frontiers in Pharmacology, Vol 8 (2017)
3-(3-Morpholinopropyl)-7,8-dihydro-6H-indeno[5,6-e][1,2,4]triazine 1,4-dioxide (SN30- 000), an analog of the well-studied bioreductive prodrug tirapazamine (TPZ), has improved activity against hypoxic cells in tumor xenografts. However, little is kno
Externí odkaz:
https://doaj.org/article/61f746173a7f46688ef3bd8d99214fa6
Autor:
Julia K. Harms, Tet-Woo Lee, Tao Wang, Amy Lai, Dennis Kee, John M. Chaplin, Nick P. McIvor, Francis W. Hunter, Andrew M. J. Macann, William R. Wilson, Stephen M.F. Jamieson
Publikováno v:
Cells, Vol 8, Iss 7, p 717 (2019)
Tumour hypoxia is a marker of poor prognosis and failure of chemoradiotherapy in head and neck squamous cell carcinoma (HNSCC), providing a strategy for therapeutic intervention in this setting. To evaluate the utility of the hypoxia-activated prodru
Externí odkaz:
https://doaj.org/article/dd7ebfffd5a142ad8a67293e0040e022
Autor:
Michael P. Hay, Hong Nam Shin, Way Wua Wong, Wan Wan Sahimi, Aaron T.D. Vaz, Pooja Yadav, Robert F. Anderson, Kevin O. Hicks, William R. Wilson
Publikováno v:
Molecules, Vol 24, Iss 14, p 2524 (2019)
Extracellular acidification is an important feature of tumor microenvironments but has yet to be successfully exploited in cancer therapy. The reversal of the pH gradient across the plasma membrane in cells that regulate intracellular pH (pHi) has po
Externí odkaz:
https://doaj.org/article/f817294cf9cf4d298cd9a829268a2ea3
Publikováno v:
Molecules, Vol 24, Iss 8, p 1559 (2019)
Poly(ADP-ribose)polymerase (PARP) inhibitors (PARPi) have recently been approved for the treatment of breast and ovarian tumors with defects in homologous recombination repair (HRR). Although it has been demonstrated that PARPi also sensitize HRR com
Externí odkaz:
https://doaj.org/article/b80c2b79d75e40bd967de4297eef8b2a
Autor:
Marina Konopleva, Peter F. Thall, Cecilia Arana Yi, Gautam Borthakur, Andrew Coveler, Carlos Bueso-Ramos, Juliana Benito, Sergej Konoplev, Yongchuan Gu, Farhad Ravandi, Elias Jabbour, Stefan Faderl, Deborah Thomas, Jorge Cortes, Tapan Kadia, Steven Kornblau, Naval Daver, Naveen Pemmaraju, Hoang Q. Nguyen, Jennie Feliu, Hongbo Lu, Caimiao Wei, William R. Wilson, Teresa J. Melink, John C. Gutheil, Michael Andreeff, Elihu H. Estey, Hagop Kantarjian
Publikováno v:
Haematologica, Vol 100, Iss 7 (2015)
We previously demonstrated vast expansion of hypoxic areas in the leukemic microenvironment and provided a rationale for using hypoxia-activated prodrugs. PR104 is a phosphate ester that is rapidly hydrolyzed in vivo to the corresponding alcohol PR-1
Externí odkaz:
https://doaj.org/article/9b9128ff96344fda8aed35d1dfe2946a