Zobrazeno 1 - 10
of 39
pro vyhledávání: '"William R. Reay"'
Autor:
William R. Reay, Dylan J. Kiltschewskij, Maria A. Di Biase, Zachary F. Gerring, Kousik Kundu, Praveen Surendran, Laura A. Greco, Erin D. Clarke, Clare E. Collins, Alison M. Mondul, Demetrius Albanes, Murray J. Cairns
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract Retinol is a fat-soluble vitamin that plays an essential role in many biological processes throughout the human lifespan. Here, we perform the largest genome-wide association study (GWAS) of retinol to date in up to 22,274 participants. We i
Externí odkaz:
https://doaj.org/article/0c655eee8d4849408b87c1536766268d
Publikováno v:
Translational Psychiatry, Vol 12, Iss 1, Pp 1-9 (2022)
Abstract Almost half of individuals diagnosed with schizophrenia also present with a substance use disorder, however, little is known about potential molecular mechanisms underlying this comorbidity. We used genetic analyses to enhance our understand
Externí odkaz:
https://doaj.org/article/24324cca5f6c40e499d166603c3d1256
Publikováno v:
Translational Psychiatry, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract Psychiatric disorders such as schizophrenia are commonly associated with structural brain alterations affecting the cortex. Recent genetic evidence suggests circulating metabolites and other biochemical traits play a causal role in many psyc
Externí odkaz:
https://doaj.org/article/1fcff63a6e2b4238b0b84498790b36e9
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Susceptibility to pneumonia has a genetic component, but specific genes involved remain poorly understood. In this study, genetic signals associated with pneumonia susceptibility are identified, providing information about disease biology and potenti
Externí odkaz:
https://doaj.org/article/b1b60a51cd964f04b60d6c7905cc9091
Publikováno v:
Human Mutation. 43:2153-2169
Psychiatric disorders and other complex traits have a polygenic architecture, often associated with dozens or even hundreds of independent genomic loci. As each of these have a relatively small influence on the trait, the dissection of their biologic
Autor:
William R. Reay, Michael P. Geaghan, Joshua R. Atkins, Vaughan J. Carr, Melissa J. Green, Murray J. Cairns
Publikováno v:
The American Journal of Human Genetics. 109:1620-1637
Genetically informed drug development and repurposing is an attractive prospect for improving patient outcomes in psychiatry; however, the effectiveness of these endeavors is confounded by heterogeneity. We propose an approach that links intervention
Autor:
William R. Reay, Rebecca Haslam, Murray J. Cairns, George Moschonis, Erin Clarke, John Attia, Clare Elizabeth Collins
Publikováno v:
Journal of Human Nutrition and Dietetics. 35:675-688
Background: The interplay between cardiovascular disease (CVD) genetic risk indexed by a polygenic risk score (PRS) and diet quality still requires further investigation amongst older adults or those with established or treated CVD. The present study
Autor:
William R. Reay, Murray J. Cairns
Publikováno v:
Nature Reviews Genetics. 22:658-671
Genome-wide association studies (GWAS) have revealed important biological insights into complex diseases, which are broadly expected to lead to the identification of new drug targets and opportunities for treatment. Drug development, however, remains
Background Anorexia nervosa (AN) is a psychiatric disorder associated with marked morbidity. Whilst AN genetic studies could identify novel treatment targets, integration of functional genomics data, including transcriptomics and proteomics, would as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62a09dd67e8c1ee4af0183c10112731c
https://doi.org/10.1101/2022.06.04.22275898
https://doi.org/10.1101/2022.06.04.22275898
Autor:
William R. Reay, Dylan J. Kiltschewskij, Michael P. Geaghan, Joshua R. Atkins, Vaughan J. Carr, Melissa J. Green, Murray J. Cairns
Publikováno v:
Science Advances. 8
There is a long-standing interest in exploring the relationship between blood-based biomarkers and psychiatric disorders, despite their causal role being difficult to resolve in observational studies. In this study, we leverage genome-wide associatio