Adaptation of Plasmodium falciparum to humans involved the loss of an ape-specific erythrocyte invasion ligand

Autor: William R. Proto, Sasha V. Siegel, Selasi Dankwa, Weimin Liu, Alison Kemp, Sarah Marsden, Zenon A. Zenonos, Steve Unwin, Paul M. Sharp, Gavin J. Wright, Beatrice H. Hahn, Manoj T. Duraisingh, Julian C. Rayner

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)

Here, Proto et al. show that human infective Plasmodium falciparum isolates contain an inactivating mutation in the erythrocyte invasion associated gene PfEBA165, while homologues of ape-infective Laverania species are intact, and that expression of

Externí odkaz: https://doaj.org/article/bd6dae0de5d54fc5a18cf05d76370dba

Adaptation of Plasmodium falciparum to humans involved the loss of an ape-specific erythrocyte invasion ligand

Autor: Manoj T. Duraisingh, Alison Kemp, Julian C. Rayner, Selasi Dankwa, William R. Proto, Paul M. Sharp, Gavin J. Wright, Zenon A. Zenonos, Steve Unwin, Weimin Liu, Sasha V. Siegel, Sarah Marsden, Beatrice H. Hahn

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Nature Communications
Proto, W R, Siegel, S V, Dankwa, S, Liu, W, Kemp, A, Marsden, S, Zenonos, Z A, Unwin, S, Sharp, P M, Wright, G J, Hahn, B H, Duraisingh, M T & Rayner, J C 2019, ' Adaptation of Plasmodium falciparum to humans involved the loss of an ape-specific erythrocyte invasion ligand ', Nature Communications, vol. 10, 4512 . https://doi.org/10.1038/s41467-019-12294-3

Plasmodium species are frequently host-specific, but little is currently known about the molecular factors restricting host switching. This is particularly relevant for P. falciparum, the only known human-infective species of the Laverania sub-genus,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3fceb976e82c3be8b6a3b1ae92873a3
https://doaj.org/article/bd6dae0de5d54fc5a18cf05d76370dba

Plasmodium falciparumATG8 implicated in both autophagy and apicoplast formation

Autor: William R. Proto, Graham H. Coombs, Andrew M Tomlins, Jeremy C. Mottram, Gordon Langsley, Roderick A.M. Williams, Fathia Ben-Rached, Ulrike Ruch, Isabelle Coppens, Tim W. Gilberger, Sylke Müller

Publikováno v: Autophagy; Vol 9

Amino acid utilization is important for the growth of the erythrocytic stages of the human malaria parasite Plasmodium falciparum, however the molecular mechanism that permits survival of the parasite during conditions of limiting amino acid supply i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fba54c19329c11f546de7c714a656d5
https://doi.org/10.4161/auto.25832

Trypanosoma brucei Metacaspase 4 Is a Pseudopeptidase and a Virulence Factor

Autor: Esther Castanys-Munoz, Laurence Tetley, Alana Black, William R. Proto, Jeremy C. Mottram, Luiz Juliano, Graham H. Coombs, Catherine X. Moss

Publikováno v: The Journal of Biological Chemistry
Repositório Institucional da UNIFESP
Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP

Background: Metacaspases are multifunctional cysteine peptidases. Results: Trypanosoma brucei metacaspase 4 is a catalytically inactive metacaspase homologue required for parasite virulence, which interacts with an active parasite metacaspase during

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a448158cc15e6f2e42d6e120cad8a73
https://doi.org/10.1074/jbc.m111.292334

A novel multiple-stage antimalarial agent that inhibits protein synthesis

Autor: Beatriz, Baragaña, Irene, Hallyburton, Marcus C S, Lee, Neil R, Norcross, Raffaella, Grimaldi, Thomas D, Otto, William R, Proto, Andrew M, Blagborough, Stephan, Meister, Grennady, Wirjanata, Andrea, Ruecker, Leanna M, Upton, Tara S, Abraham, Mariana J, Almeida, Anupam, Pradhan, Achim, Porzelle, Torsten, Luksch, María Santos, Martínez, Judith M, Bolscher, Andrew, Woodland, Suzanne, Norval, Fabio, Zuccotto, John, Thomas, Frederick, Simeons, Laste, Stojanovski, Maria, Osuna-Cabello, Paddy M, Brock, Tom S, Churcher, Katarzyna A, Sala, Sara E, Zakutansky, María Belén, Jiménez-Díaz, Laura Maria, Sanz, Jennifer, Riley, Rajshekhar, Basak, Michael, Campbell, Vicky M, Avery, Robert W, Sauerwein, Koen J, Dechering, Rintis, Noviyanti, Brice, Campo, Julie A, Frearson, Iñigo, Angulo-Barturen, Santiago, Ferrer-Bazaga, Francisco Javier, Gamo, Paul G, Wyatt, Didier, Leroy, Peter, Siegl, Michael J, Delves, Dennis E, Kyle, Sergio, Wittlin, Jutta, Marfurt, Ric N, Price, Robert E, Sinden, Elizabeth A, Winzeler, Susan A, Charman, Lidiya, Bebrevska, David W, Gray, Simon, Campbell, Alan H, Fairlamb, Paul A, Willis, Julian C, Rayner, David A, Fidock, Kevin D, Read, Ian H, Gilbert

Publikováno v: Nature, 522, 315-20
Nature, 522, 7556, pp. 315-20
Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid

Contains fulltext : 155278.pdf (Publisher’s version ) (Closed access) There is an urgent need for new drugs to treat malaria, with broad therapeutic potential and novel modes of action, to widen the scope of treatment and to overcome emerging drug

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::650155b8830359ee22f2a3f3f91f5354
https://doi.org/10.1038/nature14451