Zobrazeno 1 - 10
of 25
pro vyhledávání: '"William R. Murphy"'
Autor:
William R. Murphy
Publikováno v:
Public Works Management & Policy. 9:190-195
This article proposes the concept of dedicated small-vehicle lanes for urban commuter traffic as a more efficient alternative to dedicated truck lanes. Small-vehicle commuter lanes (SVCLs) would help mitigate many traffic-related problems. They would
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1f153db54d025f93cc303539735df68b
https://doi.org/10.1177/1087724x04271757
https://doi.org/10.1177/1087724x04271757
Autor:
Irene M. Purcell, Teresa M. Schelhorn, William F. Holt, S S Ellery, Wester Ronald Thure, William R. Murphy, Michael L. Mangiapane, Kelly A. Simpson, Andrew H. Smith
Publikováno v:
Drug Development Research. 34:361-368
Human and monkey renin are very similar, but differ from the renin of species commonly used in screening antihypertensive agents (i.e., dog and rat). This has necessitated the evaluation of renin inhibitors (Rls) in primate models. We have found that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::82f26bf0a751ac21850b65adcd8c46a7
https://doi.org/10.1002/ddr.430340408
https://doi.org/10.1002/ddr.430340408
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 4:2005-2010
Replacement of the C-terminal isopropyl ester in the orally active norstatine renin inhibitor terlakiren (1) with dialkyl phosphonate groups provided a novel series of phosphorus norstatine inhibitors 2. Cyclic phosphonate 2f (IC50 = 0.6 nM) was prep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c2706b6f1b0ca6ef923e035748830f4a
https://doi.org/10.1016/s0960-894x(01)80553-9
https://doi.org/10.1016/s0960-894x(01)80553-9
Autor:
William F. Holt, M.A. Ravi Kiron, Robert L. Rosati, Kleinman Edward F, Andrew H. Fray, Irene M. Purcell, William R. Murphy
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 4:589-592
CP-71,362 (Boc-Phe-His-hexahydroPhe[OH]Leu-Lys-Phe) has been identified as the most potent inhibitor of rat plasma renin (IC50 = 3 nM) and dog plasma renin (IC50 = 3 pM) to date and thus can be used as an important experimental tool in the study of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bb1fae6b40c19de1b4412f1a44c47c9e
https://doi.org/10.1016/s0960-894x(01)80160-8
https://doi.org/10.1016/s0960-894x(01)80160-8
Autor:
Joseph T. MacAndrew, William F. Holt, S S Ellery, William R. Murphy, Irene M. Purcell, Kleinman Edward F, Andrew H. Smith, Michael L. Mangiapane
Publikováno v:
Clinical and Experimental Hypertension. 16:507-533
Most renin inhibitors are primate-specific. In the present paper, we describe the effects of CP-71,362, a pentapeptide which preferentially inhibits canine (and to a lesser extent, rat) plasma renin. Vs. the canine enzyme, its affinity (IC50 = 3.3 x
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1d7c7cb6cfe967135ad86d1fed081e3
https://doi.org/10.3109/10641969409067959
https://doi.org/10.3109/10641969409067959
Publikováno v:
Journal of Cardiovascular Pharmacology. 21:791-796
Renal and systemic hemodynamics were studied in rats 1 month after induction of myocardial infarction by ligation of the left coronary artery. The mean arterial pressure, heart rate, and cardiac index were not different from controls, but there were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e9cd0f7721d91804ff7361de1e7b947
https://doi.org/10.1097/00005344-199305000-00016
https://doi.org/10.1097/00005344-199305000-00016
Autor:
Laura J. Weinberg, Archie C. Swindell, Roxanne L. Barber, William R. Murphy, Albert L. Rauch, Anthony A. Fossa, Mark R. Nocerini
Publikováno v:
Journal of Cardiovascular Pharmacology. 20:75-82
The effects of coadministration of a renin inhibitor, CP-80,794, and an angiotensin converting enzyme inhibitor, captopril, on blood pressure of sodium-depleted guinea pigs was studied. Dose-response curves for CP-80,794 (0.3-3.0 mg/kg i.v.) and capt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a63b10253d0cd8f4cbbd815ef38e84d
https://doi.org/10.1097/00005344-199220010-00010
https://doi.org/10.1097/00005344-199220010-00010
Autor:
Peter J. Oates, John P. Hakkinen, William F. Holt, William R. Murphy, Lawrence A. Reiter, James J. Maciejko, Goddard Carl Joseph
Publikováno v:
Digestive Diseases and Sciences. 36:1721-1728
CP-66,948 is a histamine H2-receptor antagonist with gastric antisecretory activity and mucosal protective properties. The affinity of CP-66,948 for the guinea pig atria histamine H2-receptor is 15 times greater than that of cimetidine and seven time
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c249be3f95af077dd0a9b4907fa6765
https://doi.org/10.1007/bf01296616
https://doi.org/10.1007/bf01296616
Autor:
John A. Wagner, Aziz Karim, Dawn Harper, Kristin Roman, Stephen D. Wise, William R. Murphy, Daryl S. Sonnichsen, Caroline Loew, Thorir D. Bjornsson, Marlene S. Khouri, Dennis W. Schneck, Stuart Dombey, Dennis J. Stalker, S Donahue
Publikováno v:
Journal of clinical pharmacology. 43(9)
The International Conference on Harmonization (ICH) E5 guidelines were developed to provide a general framework for evaluating the potential impact of ethnic factors on the acceptability of foreign clinical data, with the underlying objective to faci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f4f2775cd2521aae9055d17774c71f9
https://pubmed.ncbi.nlm.nih.gov/12971027
https://pubmed.ncbi.nlm.nih.gov/12971027
Autor:
Richard M. Shepard, Gregory M. Hockel, Bruce Allen Lefker, Michael L. Mangiapane, Michael J. Gumkowski, Ward H. Smith, Jasjit S. Bindra, M. J. Gardner, Robert L. Rosati, Mark R. Nocerini, William F. Holt, Wester Ronald Thure, Dennis J. Hoover, Kleinman Edward F, William R. Murphy, Ian H. Williams
Publikováno v:
Aspartic Proteinases ISBN: 9781461357612
Oral bioavailability has been a formidable barrier to the development of drugs which mimic the structures of biologically active peptides. This report describes the discovery of potent renin inhibitors having high oral bioavailability and good plasma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a28e9ffb8993c016e2a25ca68d3790d5
https://doi.org/10.1007/978-1-4615-1871-6_21
https://doi.org/10.1007/978-1-4615-1871-6_21
