Zobrazeno 1 - 10
of 97
pro vyhledávání: '"William R. Mundy"'
Autor:
William R. Mundy, Kevin M Crofton
Publikováno v:
EFSA Supporting Publications. 18
Autor:
Theresa F Freudenrich, William R. Mundy, Kathleen Wallace, Moritz Mall, Jorge Davila, Daniel Haag, Marius Wernig, Timothy J. Shafer, Lorena Saavedra
Publikováno v:
Toxicological sciences : an official journal of the Society of Toxicology. 180(2)
Assessment of neuroactive effects of chemicals in cell-based assays remains challenging as complex functional tissue is required for biologically relevant readouts. Recent in vitro models using rodent primary neural cultures grown on multielectrode a
Autor:
Christopher L. Frank, Timothy J. Shafer, Kathleen Wallace, Jasmine P. Brown, William R. Mundy
Publikováno v:
Toxicological Sciences. 160:121-135
Less than 1% of environmental chemicals have been evaluated for developmental neurotoxicity (DNT). Current guideline DNT studies are resource intensive and not amenable to screening large numbers of compounds for hazard. As part of evaluating a batte
Autor:
Andrew D. Kraft, Frances A. Champagne, Carol Starkey, Christina Sobin, Michele Taylor, Laura M. Carlson, Laura Dishaw, Susan L. Makris, Deborah Segal, William R. Mundy, Deborah A. Cory-Slechta, Elaine M. Faustman
Publikováno v:
Neurotoxicol Teratol
A key challenge in systematically incorporating mechanistic data into human health assessments is that, compared to studies of apical health endpoints, these data are both more abundant (mechanistic studies routinely outnumber other studies by severa
Autor:
Kathleen Wallace, Timothy J. Shafer, William R. Mundy, Ellese Cotterill, Stephen J. Eglen, Diana Hall
Publikováno v:
Journal of Biomolecular Screening
We examined neural network ontogeny using microelectrode array (MEA) recordings made in multiwell MEA (mwMEA) plates over the first 12 days in vitro (DIV). In primary cortical cultures, action potential spiking activity developed rapidly between DIV
Autor:
Julie R. Rice, Timothy J. Shafer, William R. Mundy, Jonathan H. Freedman, Mamta Behl, K.A. Jarema, Raymond R. Tice, Windy A. Boyd, Jui-Hua Hsieh, Stephanie Padilla, E. Sidney Hunter
Publikováno v:
Neurotoxicology and Teratology. 52:181-193
Due to their toxicity and persistence in the environment, brominated flame retardants (BFRs) are being phased out of commercial use, leading to the increased use of alternative chemicals such as the organophosphorus flame retardants (OPFRs). There is
Autor:
Theresa M. Freudenrich, Kathleen Wallace, Kenneth R. Ball, William R. Mundy, Timothy J. Shafer, Joshua A. Harrill
Publikováno v:
Toxicology and applied pharmacology. 354
Medium- to high-throughput in vitro assays that recapitulate the critical processes of nervous system development have been proposed as a means to facilitate rapid testing and identification of chemicals which may affect brain development. In vivo ne
Publikováno v:
NeuroToxicology. 49:79-85
Microelectrode array (MEA) recordings are increasingly being used as an in vitro method to detect and characterize the ability of drugs, chemicals and particles to cause neurotoxicity. While compound effects on spontaneous network activity are easily
Autor:
Marina V. Evans, William R. Mundy, Timothy J. Shafer, Chris R. Eklund, Andrew F.M. Johnstone, Rex A. Pegram, Cina M. Mack, Edward L. Croom
Publikováno v:
Toxicology and Applied Pharmacology. 283:9-19
Approaches for extrapolating in vitro toxicity testing results for prediction of human in vivo outcomes are needed. The purpose of this case study was to employ in vitro toxicokinetics and PBPK modeling to perform in vitro to in vivo extrapolation (I
Publikováno v:
Neural networks : the official journal of the International Neural Network Society. 95
Recordings of neural network activity in vitro are increasingly being used to assess the development of neural network activity and the effects of drugs, chemicals and disease states on neural network function. The high-content nature of the data der