Zobrazeno 1 - 10 of 83 pro vyhledávání: '"William R. Morton"'
1
Serendipitous Insights Involving Nonhuman Primates
Autor: Kathryn Swindler, William R. Morton
Publikováno v: ILAR Journal. 46:346-351
Serendipity is discussed as a form of controlled chaos, a phenomenon in a class with synchronicity and other actions affecting research in terms of theory versus observation (e.g., "optional stopping"). Serendipity is a fundamental aspect of basic re
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd5211d7ccf4a9fcc2b49a57e82a6ae2
https://doi.org/10.1093/ilar.46.4.346
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2
HIV in central nervous system and behavioral development
Autor: Helle Bielefeldt-Ohmann, Rodney J. Y. Ho, William R. Morton, David M. Anderson, Jennifer Leigh, Bradley D. Anderson, Shiu Lok Hu, Loren Kinman, Julie M. Worlein
Publikováno v: AIDS. 18:1363-1370
To determine which route of inoculation produced consistent and frequent HIV infection in the central nervous system (CNS) and alterations in cognitive and motor development in infant macaques.Infant macaques (Macaca nemestrina) were inoculated with
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da4424c5ef3fe0b8ad6a5c09675ad62c
https://doi.org/10.1097/01.aids.0000131307.62828.a1
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3
Cyanovirin-N Inhibits AIDS Virus Infections in Vaginal Transmission Models
Autor: Ann Schmidt, Che Chung Tsai, Michael B. Agy, William R. Morton, Peter Emau, Robin J. Shattock, Kirk R. Gustafson, Michael R. Boyd, Yonghou Jiang
Publikováno v: AIDS Research and Human Retroviruses. 20:11-18
The cyanobacterial protein cyanovirin-N (CV-N) potently inactivates diverse strains of HIV-1 and other lentiviruses due to irreversible binding of CV-N to the viral envelope glycoprotein gp120. In this study, we show that recombinant CV-N effectively
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e3808fc3c8b8fc18e9feb66e2d6db6d
https://doi.org/10.1089/088922204322749459
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4
Post-exposure chemoprophylaxis (PECP) against SIV infection of macaques as a model for protection from HIV infection
Autor: Joseph C. Sun, Peter Emau, William R. Morton, Norbert Bischofberger, Kathryn E. Follis, Thomas W. Beck, Chy-Anh Tran, Che-Chung Tsai
Publikováno v: Journal of Medical Primatology. 29:248-258
We report that simian immunodeficiency virus (SIV) infection in macaques is a valuable animal model for studying post-exposure chemoprophylaxis (PECP). PECP with the acyclic nucleoside reverse transcriptase inhibitors 9-(2-phosphonylmetho-xyethyl)ade
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::25ed6f449b193d137651b664e4db69a9
https://doi.org/10.1034/j.1600-0684.2000.290318.x
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5
Enhanced safety and efficacy of live attenuated SIV vaccines by prevaccination with recombinant vaccines
Autor: William R. Morton, Shabbir Ahmad, Leslie A. Jones, Tilahun Yilma, Richard Grant, Paulo H. Verardi, Kenneth S. Chan
Publikováno v: Journal of Medical Primatology. 29:231-239
The only vaccines shown to be protective against intravenous challenge with virulent virus in the simian immunodeficiency virus (SIV)/macaque model are attenuated live SIVs. However, these vaccines have several disadvantages: 1) they persist indefini
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::939f62175a2e63efbd5be46c092bc2c1
https://doi.org/10.1034/j.1600-0684.2000.290316.x
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6
Derivation and characterization of a highly pathogenic isolate of human immunodeficiency virus type 2 that causes rapid CD4+ cell depletion in Macaca nemestrina
Autor: William R. Morton, Jeannette Bannink, Ann Schmidt, David M. Anderson, Janela McClure, Che Chung Tsai, Marie Anne Rey-Cuille, Lynda Misher, Shiu Lok Hu
Publikováno v: Journal of Medical Primatology. 29:114-126
With few exceptions, humans are the only species known to develop acquired immunodeficiency syndrome (AIDS) after human immunodeficiency virus (HIV) infection. We report here that an isolate of HIV type 2, EHO, readily established persistent infectio
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::24991a5fdd523fda7c6ff8cd539e426c
https://doi.org/10.1034/j.1600-0684.2000.290304.x
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7
Enhanced replication of HIV-1 in vivo in pigtailed macaques (Macaca nemestrina)
Autor: William R. Morton, Jiangli Chen, Mary Jo Florey, Marnix L. Bosch, Michael B. Agy, Ann Schmidt
Publikováno v: Journal of Medical Primatology. 29:107-113
Non-human primate models for acquired immunodeficiency syndrome (AIDS) are important for studies of prevention and intervention strategies. Ideally, such models would make use of human immunodeficiency virus type 1 (HIV-1) and animals that are readil
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2733ce35eba34ebc9f051b553b553f37
https://doi.org/10.1034/j.1600-0684.2000.290303.x
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8
Viral dynamics of early HIV infection in neonatal macaques after oral exposure to HIV-2287 : an animal model with implications for maternal-neonatal HIV transmission
Autor: John B. Lynch, Ann Schmidt, Michael B. Agy, Michael N. Robertson, C. Sherbert, William R. Morton, Michael S. Rabin, David M. Anderson, Arnd M. Herz, P. D. Greenberg, Shiu Lok Hu
Publikováno v: Journal of Medical Primatology. 31:29-39
A model of vertical HIV transmission was developed using oral HIV-2 2 8 7 exposure of newborn Macaca nemestrina. The minimal Animal Infectious Dose for this oral route was found to be 10-fold higher than that for atraumatic viral transmission across
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a097d41140d3983432032f942950293c
https://doi.org/10.1034/j.1600-0684.2002.1o005.x
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10
Suppression of Maternal Virus Load With Zidovudine, Didanosine, and Indinavir Combination Therapy Prevents Mother-to-Fetus HIV Transmission in Macaques
Autor: Xiao Y. Wang, Jashvant D. Unadkat, Connie Nosbisch, C. Sherbert, Michael B. Agy, William R. Morton, Arnd M. Herz, Kay Larsen, David Anderson, Rodney J. Y. Ho, Eric E. Finn, Ann Schmidt, Tot Bui
Publikováno v: JAIDS Journal of Acquired Immune Deficiency Syndromes. 25:140-149
Recently, we developed a maternal-fetal macaque model using a highly pathogenic HIV-2 strain, HIV-2 287 , to study the time course of HIV transmission in utero. Most pregnant macaques (Macaca nemestrina) infected with HIV-2 287 (10-10 3 infective dos
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d42b2513600756c15b544b5f8fbd7b68
https://doi.org/10.1097/00126334-200010010-00008
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