Zobrazeno 1 - 10
of 214
pro vyhledávání: '"William R. Martin"'
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 5, p 1550 (2020)
Gain-of-function mutations in PCSK9 (proprotein convertase subtilisin/kexin type 9) lead to reduced uptake of LDL (low density lipoprotein) cholesterol and, therefore, increased plasma LDL levels. However, the mechanism by which these mutants reduce
Externí odkaz:
https://doaj.org/article/93a05a515ba74824a26050d48a702026
Autor:
Feixiong Cheng, William R. Martin
Publikováno v:
ChemRxiv
article-version (number) 1
article-version (status) pre
article-version (number) 1
article-version (status) pre
The ongoing global health crisis caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the virus which leads to Coronavirus Disease 2019 (COVID-19) has impacted not only the health of people everywhere, but the economy in nations ac
Autor:
Ruth A. Keri, Justin D. Lathia, Raul Rabadan, Elliott M. Antman, Felice C. Lightstone, Jessica A. Castrillon, Rui-Sheng Wang, Tong Hao, Marc Vidal, Zehui Liu, Yadi Zhou, David E. Hill, Hong Yue, Yuan Hou, Joseph Loscalzo, Jiansong Fang, Feixiong Cheng, Junfei Zhao, Yang Wang, William R. Martin, Jing Ma, Charis Eng, Weiqiang Lu, Jin Huang
Publikováno v:
Nat Genet
Technological and computational advances in genomics and interactomics have made it possible to identify how disease mutations perturb protein–protein interaction (PPI) networks within human cells. Here, we show that disease-associated germline var
Publikováno v:
Nuclear Science and Engineering. 194:1025-1043
Multigroup constants for deterministic methods that preserve the time-dependent physics of the neutron transport equations are derived. Alternative multigroup constant weighting spectra are discuss...
Publikováno v:
Curr Opin Struct Biol
The rapid increase in computing power, especially with the integration of graphics processing units, has dramatically increased the capabilities of molecular dynamics simulations. To date, these capabilities extend from running very long simulations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1aaa5768c2810580e8e8355710c2bab0
https://europepmc.org/articles/PMC8860862/
https://europepmc.org/articles/PMC8860862/
Autor:
Jipu Wang, William R. Martin, Thomas J. Downar, Brendan Kochunas, Nathan C. Andrews, Lindsay Gilkey, Erik D. Walker, Benjamin S. Collins, Martin Pilch
Publikováno v:
Annals of Nuclear Energy. 178:109365
Publikováno v:
Annals of Nuclear Energy. 128:84-93
In reactor core analysis, equilibrium delayed fission energy is often assumed except for estimating the decay heat during reactor shutdown or post-accident scenarios. In this paper, we investigated a few slow and fast transient operational conditions
Autor:
David W. Ball, William R. Martin
Publikováno v:
Journal of Energetic Materials. 37:70-79
The minimum-energy structures and thermodynamic properties of small organic fulminate molecules have been explored. The results show that while these compounds have an impressive specific energy of decomposition, other parameters like detonation pres
Autor:
Ruth Nussinov, Lang Li, Feixiong Cheng, Timothy A. Chan, Junfei Zhao, William R. Martin, Yadi Zhou, Jiansong Fang, Charis Eng
Publikováno v:
Genome Biology
Genome Biology, Vol 22, Iss 1, Pp 1-18 (2021)
Genome Biology, Vol 22, Iss 1, Pp 1-18 (2021)
Massive genome sequencing data have inspired new challenges in personalized treatments and facilitated oncological drug discovery. We present a comprehensive database, My Personal Mutanome (MPM), for accelerating the development of precision cancer m
Autor:
Brendan Kochunas, Xinyan Wang, Matthew Kabelitz, Robert Salko, Kang Seog Kim, William R. Martin, Benjamin Collins, Yuxuan Liu
Publikováno v:
EPJ Web of Conferences, Vol 247, p 02033 (2021)
The default energy deposition model in the CASL neutronics code MPACT assumes all fission energy is deposited locally in fuel rods. Furthermore, equilibrium delayed energy release is assumed for both steady-state and transient calculations. These app