Zobrazeno 1 - 10
of 56
pro vyhledávání: '"William R. Lieb"'
Autor:
Marco Gruss, Nicholas P. Franks, Alistair Mathie, William R. Lieb, Trevor J. Bushell, Damian P. Bright
Publikováno v:
Molecular Pharmacology. 65:443-452
Nitrous oxide, xenon, and cyclopropane are anesthetic gases that have a distinct pharmacological profile. Whereas the molecular basis for their anesthetic actions remains unclear, they behave very differently to most other general anesthetics in that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e1631def547af3a50add5325ca267dd
https://doi.org/10.1124/mol.65.2.443
https://doi.org/10.1124/mol.65.2.443
Publikováno v:
Neuropharmacology. 44:864-872
The effects of general anaesthetics and temperature on carbachol-evoked gamma oscillations in the rat hippocampal brain slice preparation were investigated. The frequency of the oscillations was found to be dependent on temperature in the range 32-25
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e7742d26eae54d17d2b4028019ff583
https://doi.org/10.1016/s0028-3908(03)00083-2
https://doi.org/10.1016/s0028-3908(03)00083-2
Publikováno v:
Anesthesiology. 96:884-892
Background There is conflicting evidence concerning the extent to which the intravenous general anesthetic thiopental acts by enhancing inhibitory gamma-aminobutyric acid-mediated (GABAergic) synaptic transmission or by inhibiting excitatory glutamat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2700ea795c19e77a061be325db9892fc
https://doi.org/10.1097/00000542-200204000-00016
https://doi.org/10.1097/00000542-200204000-00016
Publikováno v:
Anesthesiology. 93:837-843
Background Although it is accepted widely that optically active intravenous general anesthetics produce stereoselective effects in animals, the situation regarding volatile agents is confused. Conventional studies with scarce isoflurane enantiomers h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7574e04d2b22dab78051d8eb9649ea0
https://doi.org/10.1097/00000542-200009000-00035
https://doi.org/10.1097/00000542-200009000-00035
Publikováno v:
Anesthesiology. 92:1055-1066
Background The mechanisms by which the inhalational general anesthetics isoflurane and xenon exert their effects are unknown. Moreover, there have been surprisingly few quantitative studies of the effects of these agents on central synapses, with vir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3acd226be288f4e5e465f7815b15633a
https://doi.org/10.1097/00000542-200004000-00024
https://doi.org/10.1097/00000542-200004000-00024
Publikováno v:
Anesthesiology. 90:484-491
Background Potentiation of the activity of the gamma-aminobutyric acid type A (GABA(A)) receptor channel by volatile anesthetic agents is usually studied in vitro at room temperature. Systematic variation of temperature can be used to assess the rele
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9a682e086954032cc8fd28d4cc0654a
https://doi.org/10.1097/00000542-199902000-00024
https://doi.org/10.1097/00000542-199902000-00024
Publikováno v:
Biophysical Journal. 75:2205-2211
The firefly luciferase enzyme from Photinus pyralis is probably the best-characterized model system for studying anesthetic-protein interactions. It binds a diverse range of general anesthetics over a large potency range, displays a sensitivity to an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ab4f5a9940244bf1aa631c8b28b5e48
https://doi.org/10.1016/s0006-3495(98)77664-7
https://doi.org/10.1016/s0006-3495(98)77664-7
Publikováno v:
British Journal of Pharmacology. 125:309-318
1 K+ currents activated by volatile general anaesthetics (IK(An)) and by the neuropeptide FMRFamide (IK(FMRFa)) were studied under voltage clamp in isolated identified neurones from the pond snail Lymnaea stagnalis. 2 IK(An) was activated by all the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::05f6e931235d8fe6e76dc2f06741aefe
https://doi.org/10.1038/sj.bjp.0702069
https://doi.org/10.1038/sj.bjp.0702069
Publikováno v:
Anesthesiology. 88:708-717
Background The intravenous anesthetic etomidate is optically active and exists in two mirror-image enantiomeric forms. However, although the R(+) isomer is used as a clinical anesthetic, quantitative information on the relative potencies of the R(+)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::53d17c1113257320ecdab6432f38288e
https://doi.org/10.1097/00000542-199803000-00022
https://doi.org/10.1097/00000542-199803000-00022
Publikováno v:
British Journal of Pharmacology. 118:493-502
1. Glycine responses were studied under voltage clamp in Xenopus oocytes injected with cDNA encoding mammalian glycine receptor subunits and in rat medullary neurones. Bath application of glycine gave strychnine-sensitive currents which reversed clos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95d08c8d6fef83fd177d089a065ec7ae
https://doi.org/10.1111/j.1476-5381.1996.tb15430.x
https://doi.org/10.1111/j.1476-5381.1996.tb15430.x