Zobrazeno 1 - 10
of 48
pro vyhledávání: '"William R. Jeck"'
BET Protein Inhibition Regulates Macrophage Chromatin Accessibility and Microbiota-Dependent Colitis
Autor:
Michelle Hoffner O’Connor, Ana Berglind, Meaghan M. Kennedy Ng, Benjamin P. Keith, Zachary J. Lynch, Matthew R. Schaner, Erin C. Steinbach, Jeremy Herzog, Omar K. Trad, William R. Jeck, Janelle C. Arthur, Jeremy M. Simon, R. Balfour Sartor, Terrence S. Furey, Shehzad Z. Sheikh
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
IntroductionIn colitis, macrophage functionality is altered compared to normal homeostatic conditions. Loss of IL-10 signaling results in an inappropriate chronic inflammatory response to bacterial stimulation. It remains unknown if inhibition of bro
Externí odkaz:
https://doaj.org/article/16bc63fbe0be4e3aa778fb80c11bd93c
Autor:
James D. Byrne, Cameron C. Young, Jacqueline N. Chu, Jennifer Pursley, Mu Xian Chen, Adam J. Wentworth, Annie Feng, Ameya R. Kirtane, Kyla A. Remillard, Cindy I. Hancox, Mandar S. Bhagwat, Nicole Machado, Tiffany Hua, Siddartha M. Tamang, Joy E. Collins, Keiko Ishida, Alison Hayward, Sarah L. Becker, Samantha K. Edgington, Jonathan D. Schoenfeld, William R. Jeck, Chin Hur, Giovanni Traverso
Publikováno v:
Advanced Science, Vol 8, Iss 12, Pp n/a-n/a (2021)
Abstract Cancer patients undergoing therapeutic radiation routinely develop injury of the adjacent gastrointestinal (GI) tract mucosa due to treatment. To reduce radiation dose to critical GI structures including the rectum and oral mucosa, 3D‐prin
Externí odkaz:
https://doaj.org/article/c0323e01371e419f83b88c37c467070f
Publikováno v:
Current Treatment Options in Oncology. 24:212-228
Publikováno v:
Clin Liver Dis (Hoboken)
Autor:
Norman E. Sharpless, Sharon L. Campbell, Bruce C. Baguley, Michael J. Miley, Daniel C. Zedek, David B. Darr, George P. Souroullas, William R. Jeck, Brit L. Martin, Kailing Fu, Kelly S. Clark, James E. Gillahan, Meriam A. Waqas, Minh V. Huynh, Wenjin Liu, Christin E. Burd
Figure S1. Generation of the LSL-N-RasQ61R allele. Figure S2. Conditional expression of N-Ras mutants does not alter melanocyte morphology. Figure S3. In both the heterozygous and homozygous state, NRasG12D fails to induce melanoma formation. Figure
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a5c3e3adfbf56270fa607f7d8df27f8
https://doi.org/10.1158/2159-8290.22530242.v1
https://doi.org/10.1158/2159-8290.22530242.v1
Autor:
Norman E. Sharpless, Sharon L. Campbell, Bruce C. Baguley, Michael J. Miley, Daniel C. Zedek, David B. Darr, George P. Souroullas, William R. Jeck, Brit L. Martin, Kailing Fu, Kelly S. Clark, James E. Gillahan, Meriam A. Waqas, Minh V. Huynh, Wenjin Liu, Christin E. Burd
NRAS mutation at codons 12, 13, or 61 is associated with transformation; yet, in melanoma, such alterations are nearly exclusive to codon 61. Here, we compared the melanoma susceptibility of an NrasQ61R knock-in allele to similarly designed KrasG12D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b07545ea77a4bfaa05fa90bb50b2e69
https://doi.org/10.1158/2159-8290.c.6546137.v1
https://doi.org/10.1158/2159-8290.c.6546137.v1
Autor:
David Dov, William R. Jeck, Kyle Lafata, Colin L. Cooke, Jeffrey I. Everitt, Carolyn Glass, Roarke Horstmeyer, Matthew Glass, Michael A. Seidman
Publikováno v:
Canadian Journal of Cardiology. 38:234-245
Machine learning has seen slow but steady uptake in diagnostic pathology over the past decade to assess digital whole slide images. Machine learning tools have incredible potential to standardize, and likely even improve, histopathologic diagnoses, b
Publikováno v:
Human Pathology. 116:63-72
Summary Primary hepatic neoplasms with neuroendocrine differentiation are extremely rare. Their clinicopathological features and molecular genetic basis are largely unknown. We identified four cases of primary hepatic neoplasms with neuroendocrine di
Publikováno v:
The Journal of Molecular Diagnostics. 23:630-636
The identification of gene fusions is a cornerstone of diagnosis and treatment decision making for tumors of many forms and primary sites. Diverse molecular approaches are currently used for the molecular diagnosis of fusions, but few permit broad, p
Autor:
James D. Byrne, David Gallo, Hannah Boyce, Sarah L. Becker, Kristi M. Kezar, Alicia T. Cotoia, Vivian R. Feig, Aaron Lopes, Eva Csizmadia, Maria Serena Longhi, Jung Seung Lee, Hyunjoon Kim, Adam J. Wentworth, Sidharth Shankar, Ghee Rye Lee, Jianling Bi, Emily Witt, Keiko Ishida, Alison Hayward, Johannes L. P. Kuosmanen, Josh Jenkins, Jacob Wainer, Aya Aragon, Kaitlyn Wong, Christoph Steiger, William R. Jeck, Dustin E. Bosch, Mitchell C. Coleman, Douglas R. Spitz, Michael Tift, Robert Langer, Leo E. Otterbein, Giovanni Traverso
Publikováno v:
Sci Transl Med
Carbon monoxide (CO) has long been considered a toxic gas but is now a recognized bioactive gasotransmitter with potent immunomodulatory effects. Although inhaled CO is currently under investigation for use in patients with lung disease, this mode of