Zobrazeno 1 - 7
of 7
pro vyhledávání: '"William R. Hays"'
Autor:
Jennifer S. Janssen, Bryan R. Haugen, William R. Hays, Meenakshi Singh, Vibha Sharma, Reid P. Bissonnette, Andrew Berenz, Umarani Pugazhenthi, Joshua P. Klopper
Publikováno v:
Clinical Cancer Research. 14:589-596
Purpose: Anaplastic thyroid carcinoma is rare, yet lethal despite aggressive therapy. Molecular targeting may be beneficial using the rexinoid LGD1069, a retinoid X receptor–selective agonist, as a novel treatment. In this report, we describe the e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df54fe78c87d8b4c6165a9de7b921247
https://doi.org/10.1158/1078-0432.ccr-07-0269
https://doi.org/10.1158/1078-0432.ccr-07-0269
Autor:
Wojciech Krezel, Bryan R. Haugen, Pierre Chambon, Vibha Sharma, Dalan R. Jensen, Leslie K. Pulawa, Robert H. Eckel, William R. Hays
Publikováno v:
Endocrinology
Endocrinology, 2004, 145 (8), pp.3679-3685. ⟨10.1210/en.2003-1401⟩
Endocrinology, 2004, 145 (8), pp.3679-3685. ⟨10.1210/en.2003-1401⟩
Retinoids, derivatives of vitamin A, induce hypertriglyceridemia through decreased clearance of very low-density lipoprotein by a lipoprotein lipase (LPL)-dependent pathway. The retinoid X receptor (RXR) gamma isotype, which is highly expressed in sk
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::858a6dcc5780282c50dd06d6aa433cb4
https://doi.org/10.1210/en.2003-1401
https://doi.org/10.1210/en.2003-1401
Autor:
Joshua P. Klopper, William R. Hays, Vibha Sharma, Margaret A. Baumbusch, Jerome M. Hershman, Bryan R. Haugen
Publikováno v:
Molecular Cancer Therapeutics. 3:1011-1020
Poorly differentiated, metastatic thyroid cancer is difficult to treat. These tumors often do not concentrate radioactive iodine and may require chemotherapy, which is suboptimal and toxic. Nuclear hormone receptors peroxisome proliferator-activated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4607d20d69f5d26e47529f130801d18d
https://doi.org/10.1158/1535-7163.1011.3.8
https://doi.org/10.1158/1535-7163.1011.3.8
Autor:
William R. Hays, Vibha Sharma, Lori Lee Larson, Joshua P. Klopper, Cynthia A. Kramer, Bryan R. Haugen, Umarani Pugazhenthi
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 89:272-280
Therapy for patients with advanced thyroid carcinoma is limited. Clinical and in vitro studies suggest that some patients with advanced thyroid cancer may respond to therapy with retinoic acid. mRNA expression of the six retinoic acid (RAR) and retin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a87a04251c1269b431d16e371b0d332a
https://doi.org/10.1210/jc.2003-030770
https://doi.org/10.1210/jc.2003-030770
Autor:
Vibha Sharma, Antonio C. Bianco, Donald L. St. Germain, William R. Hays, Umarani Pugazhenthi, William M. Wood, Pierre Chambon, Bryan R. Haugen, Wojciech Krezel
Publikováno v:
Endocrinology
Endocrinology, Endocrine Society, 2006, 147 (3), pp.1438-51. ⟨10.1210/en.2005-0706⟩
ResearcherID
Endocrinology, Endocrine Society, 2006, 147 (3), pp.1438-51. ⟨10.1210/en.2005-0706⟩
ResearcherID
International audience; Retinoid X receptor (RXR)-selective retinoids (rexinoids) can cause central hypothyroidism in humans, and this effect has been confirmed in rodent models. In this report, we characterized the effect of rexinoids on the hypotha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5827bbc3c53a5aa5363a9b99fbecde23
https://hal.archives-ouvertes.fr/hal-00188142
https://hal.archives-ouvertes.fr/hal-00188142
Autor:
Joshua P, Klopper, William R, Hays, Vibha, Sharma, Margaret A, Baumbusch, Jerome M, Hershman, Bryan R, Haugen
Publikováno v:
Molecular cancer therapeutics. 3(8)
Poorly differentiated, metastatic thyroid cancer is difficult to treat. These tumors often do not concentrate radioactive iodine and may require chemotherapy, which is suboptimal and toxic. Nuclear hormone receptors peroxisome proliferator-activated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3d7bd3cf1cec3275b57380806389e469
https://pubmed.ncbi.nlm.nih.gov/15299084
https://pubmed.ncbi.nlm.nih.gov/15299084
Autor:
Michele M Loi, Vibha Sharma, Umarani Pugazhenthi, Bryan R. Haugen, Sherif Said, Andrew Berenz, Joshua P. Klopper, William R. Hays
Publikováno v:
Molecular Cancer, Vol 8, Iss 1, p 16 (2009)
Molecular Cancer
Molecular Cancer
Background Metastatic melanoma has a high mortality rate and suboptimal therapeutic options. Molecular targeting may be beneficial using the rexinoid LGD1069, a retinoid × receptor selective agonist, and thiazolidinediones (TZD), PPARγ selective li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd544e354d9a29d24281c223999ff45e