Zobrazeno 1 - 10
of 11
pro vyhledávání: '"William R. Couet"'
Publikováno v:
Journal of pharmacokinetics and biopharmaceutics. 19(3)
A pharmacokinetic model incorporating saturable rate of absorption of the Michaelis-Menten type was recently developed to fit cefatrizine (CFZ) plasma concentrations with time following oral administration of 500-mg capsules to humans. This model (MM
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4aa64f8a3e694ec9343740bc8b42e25b
https://pubmed.ncbi.nlm.nih.gov/1875282
https://pubmed.ncbi.nlm.nih.gov/1875282
Autor:
Jean-Paul Guedes, William R. Couet, Bruno G. Reigner, Thomas N. Tozer, Jean-Bernard Fourtillan
Publikováno v:
Journal of pharmacokinetics and biopharmaceutics. 18(1)
This study examined the absorption kinetics of cefatrizine, an amino-beta-lactam antibiotic, after oral administration of a single 500-mg dose to 12 healthy volunteers. Plasma concentrations were determined by high performance liquid chromatography.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56c1e3ffe3558f8293397a6a644c1e92
https://pubmed.ncbi.nlm.nih.gov/2329468
https://pubmed.ncbi.nlm.nih.gov/2329468
Autor:
D.E. Nitecki, William R. Couet, L D Tuck, Robert C. Brasch, George E. Wesbey, Thomas N. Tozer, Ulf G. Eriksson
Publikováno v:
Pharmaceutical Research. :203-209
Paramagnetic nitroxyl-containing compounds have been useful as contrast agents in magnetic resonance imaging (MRI) experiments in animals. Preliminary information on the metabolic fate, pharmacokinetic behavior, stability in tissues, and chemical red
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9069962e6bbdd693a64baf882344581c
https://doi.org/10.1023/a:1016317212601
https://doi.org/10.1023/a:1016317212601
Autor:
Indra Prakash, William R. Couet, Thomas N. Tozer, George Sosnovsky, Nuti Uma Maheswara Rao, R L Ehman, Robert C. Brasch, M T McNamara
Publikováno v:
European Journal of Medicinal Chemistry. 24:335-340
An attempt was made to develop guidelines for the design of new contrast agents using nitroxyl spin labels (NSL). The structural parameters of ring size and of substituents were correlated with the stability towards reduction and the relaxation effec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::76d8b7ac2e40070d718cf2e2d4fa447c
https://doi.org/10.1016/0223-5234(89)90075-5
https://doi.org/10.1016/0223-5234(89)90075-5
Autor:
Thomas N. Tozer, Indra Prakash, William R. Couet, C.T. Gnewech, Robert C. Brasch, C. Sosnovsky, Jan Lukszo
Publikováno v:
Tetrahedron. 41:1165-1172
The Influence of structure on the reduction of nitroxyl spin labels by ascorbic acid was examined using both piperidine and pyrrolidine nitroxyls. A five-fold molar excess of ascorbic acid and pH of 7.4 were used. The nitroxyl concentration was measu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::33c6f90a0a6cccfd42da0d16a07d053e
https://doi.org/10.1016/s0040-4020(01)96516-0
https://doi.org/10.1016/s0040-4020(01)96516-0
Publikováno v:
Magnetic Resonance Imaging. 3:83-88
Because of their paramagnetic properties, nitroxides are potentially useful as contrast agents in magnetic resonance imaging (MRI). They are reduced in vivo to their corresponding hydroxylamines which are nonparamagnetic and have no contrast enhancin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6f612af912b1e39003969813aa6ba1c
https://doi.org/10.1016/0730-725x(85)90012-8
https://doi.org/10.1016/0730-725x(85)90012-8
Publikováno v:
Pharmaceutical Research. :69-72
Two nitroxide spin labels called PCA and TES have been used experimentally as contrast enhancing agents in magnetic resonance imaging. Pharmacokinetic data for these nitroxides, after intravenous administration to three dogs at two dose levels (0.1 a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::89dd4d1902539f6aa9d63514c090840e
https://doi.org/10.1023/a:1016334510417
https://doi.org/10.1023/a:1016334510417
Autor:
George E. Wesbey, Thomas N. Tozer, Robert C. Brasch, Richard D. Williams, M T McNamara, Kirk L. Moon, William R. Couet, R L Ehman
Publikováno v:
Magnetic Resonance Imaging. 3:89-97
Nitroxyl spin labels have been shown to be effective in vivo contrast agents for magnetic resonance imaging (MRI) of the central nervous system, myocardium, and urinary tract. A new pyrrolidine nitroxyl contrast agent (PCA) with better resistance to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::892b3c5b25e9ac8e6e6c770d2812192a
https://doi.org/10.1016/0730-725x(85)90013-x
https://doi.org/10.1016/0730-725x(85)90013-x
Autor:
Bertrand Istin, Jean-jacques Floch, Jean-frédéric Sauniere, Jean-Bernard Fourtillan, Roland Laroche, William R. Couet
Publikováno v:
Europe PubMed Central
The pharmacokinetics of quinine was investigated in patients with acute falciparum malaria treated with quinine alone or in the presence of doxycycline. Twenty-six patients divided into two groups of equal number were enrolled in the study. In the ab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57fdb32b7ff2df1afccfd69693d7194b
http://europepmc.org/abstract/med/1771646
http://europepmc.org/abstract/med/1771646
Autor:
George E. Wesbey, Ulf G. Eriksson, D. Revel, T. N. Tozer, George Sosnovsky, William R. Couet, M T McNamara, R L Ehman, B. L. Engelstab, R C Brasch, Jeffrey Lovin
Publikováno v:
Investigative Radiology. 19:S20
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9f15527c104a5d53adaaba35f3b58c8d
https://doi.org/10.1097/00004424-198409000-00101
https://doi.org/10.1097/00004424-198409000-00101