Zobrazeno 1 - 10
of 18
pro vyhledávání: '"William R. Cantrell"'
Autor:
Tony E. Reeves, Jonathan Bohmann, William E. Bauta, Donald M. Maxwell, Bismarck Campos, Michael W. Tidwell, Stanton F. McHardy, Michael R. Corbett, Richard E. Sweeney, Ambrosio Lopez, William R. Cantrell, John McDonough, Karen M. Brecht, Christopher J. Bemben, Tony A. Menchaca, Paul M. Thompson
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 24:1711-1714
The goal of this research was to identify structurally novel, non-quaternarypyridinium reactivators of GF (cyclosarin)-inhibited hAChE that possess the capacity to mediate in vitro reactivation of GF-inhibited human acetylcholinesterase (hAChE). New
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfcd5b41e8cf482b063cb4808aef97ff
https://doi.org/10.1016/j.bmcl.2014.02.049
https://doi.org/10.1016/j.bmcl.2014.02.049
Autor:
Michelle Busch, James E. Stefano, Beverly A. Teicher, Dennis Lovett, William E. Bauta, Steven Schmid, Diego A. Gianolio, Peng Pan, Cecile Rouleau, Roy Krumbholz, Paul Wolstenholme-Hogg, James Goebel, Stephanie Roth, Antonio Recio, Hildegard M. Kramer, William R. Cantrell
Publikováno v:
Cancer Chemotherapy and Pharmacology. 70:439-449
Targeting tubulin binders to cancer cells using antibody–drug conjugates (ADCs) has great potential to become an effective cancer treatment with low normal tissue toxicity. The nature of the linker used to tether the tubulin binder to the antibody
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f2ac46d3af853564d3611cf7f3ff1a8
https://doi.org/10.1007/s00280-012-1925-8
https://doi.org/10.1007/s00280-012-1925-8
Publikováno v:
Organic Process Research & Development. 16:967-975
Doxercalciferol (1α-hydroxyvitamin D2) is a commercially approved vitamin D derivative used to treat chronic kidney disease (CKD) patients whose kidneys cannot metabolically introduce a hydroxyl gr...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::07a36aa24427f9e4c682c184006f7223
https://doi.org/10.1021/op200346g
https://doi.org/10.1021/op200346g
Publikováno v:
Molecules
Volume 23
Issue 7
Molecules, Vol 23, Iss 7, p 1791 (2018)
Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry
Volume 23
Issue 7
Molecules, Vol 23, Iss 7, p 1791 (2018)
Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry
Wortmannin is a potent covalent inhibitor of PI3K that shows substantial in vivo toxicity and thus is unsuitable for systemic therapeutic applications. One possible approach to minimize systemic toxicity is to generate a latent wortmannin pro-drug th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77dae277715cea7beaffe1b5557bcc66
https://doi.org/10.3390/molecules23071791
https://doi.org/10.3390/molecules23071791
Isolation, Synthesis, and Characterization of Impurities and Degradants from the Clofarabine Process
Publikováno v:
Organic Process Research & Development. 12:1229-1237
The identification of clofarabine process impurities and their subsequent isolation, synthesis, and characterization is described. Two isomeric process impurities resulting from N6-attachment of a fluoroarabinose to clofarabine were found. Clofarabin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::408be24a8609ca3085ecaca142ed57ad
https://doi.org/10.1021/op800182x
https://doi.org/10.1021/op800182x
Autor:
Larry Arthaud, Steven D. Weitman, Peter L. Bonate, William R. Cantrell, Katherine Stephenson, John A. Secrist
Publikováno v:
Nature Reviews Drug Discovery. 5:855-863
Despite considerable progress in the treatment of paediatric leukaemias, a major need still exists for therapies for patients who relapse. Bonate and colleagues describe the discovery and development of the nucleoside analogue clofarabine, which is t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::049544cfee7c634ee1375322dab8a4e4
https://doi.org/10.1038/nrd2055
https://doi.org/10.1038/nrd2055
Autor:
Brian Burke, Jose Puente, James Goebel, Brian E. Schulmeier, Dennis Lovett, William R. Cantrell, Dumitru Ionescu, Bruce T. Anderson, Ruichao Guo, William E. Bauta
Publikováno v:
Organic Process Research & Development. 8:889-896
Clofarabine is a promising DNA polymerase inhibitor currently in clinical trials for a variety of liquid and solid tumor indications. The efforts for development of a new manufacturing process for clofarabine are presented. This new process allows fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0f68a7f1e934dbe97610a7b9682e3532
https://doi.org/10.1021/op049884n
https://doi.org/10.1021/op049884n
Publikováno v:
The Journal of Organic Chemistry. 68:5967-5973
We report the formal synthesis of angiogenesis inhibitor NM-3 (1) in six steps from either of the 2,4-dimethoxyhalobenzenes 13a,b or 3,5-dimethoxychlorobenzene (13c). The first key reaction is the regiospecific alkylation/rearrangement between the ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::409e118ef0a41f7017e0895350b18020
https://doi.org/10.1021/jo034165c
https://doi.org/10.1021/jo034165c
Publikováno v:
Tetrahedron Letters. 47:4249-4251
Addition of aqueous hydrogen peroxide significantly accelerates the substitution reactions of hydroxide salts with haloarenes bearing electron withdrawing substituents. A similar effect is observed in the reactions of hydroxide salts with halogenated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6547495501abff6e4ec4f59d765ec1e5
https://doi.org/10.1016/j.tetlet.2006.04.020
https://doi.org/10.1016/j.tetlet.2006.04.020
Publikováno v:
Journal of Organometallic Chemistry. 472:195-204
Reactions of (η 5 -C 5 H 5 )Re(NO)(PPh 3 )(OTf) and the cyclic amines H NCH 2 CH 2 (C H 2 ) n -4 give adducts [(η 5 -C 5 H 5 )-Re(NO)(PPh 3 )(HNCH 2 CH 2 CH 2 (CH 2 ) n -4 )] + TfO − ; ( 3a-e + TfO − ; n = a , 3; b , 4; c , 5; d , 6; e , 7) in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::899ecd16c7e354d71cdd5b42b98b2359
https://doi.org/10.1016/0022-328x(94)80206-8
https://doi.org/10.1016/0022-328x(94)80206-8