Zobrazeno 1 - 10
of 14
pro vyhledávání: '"William R. Bourn"'
Autor:
Rosamund Chapman, William R Bourn, Enid Shephard, Helen Stutz, Nicola Douglass, Thandi Mgwebi, Ann Meyers, Nyasha Chin'ombe, Anna-Lise Williamson
Publikováno v:
PLoS ONE, Vol 9, Iss 7, p e103314 (2014)
Numerous features make Mycobacterium bovis BCG an attractive vaccine vector for HIV. It has a good safety profile, it elicits long-lasting cellular immune responses and in addition manufacturing costs are affordable. Despite these advantages it is of
Externí odkaz:
https://doaj.org/article/88b4227fa0fd4e378189e633d326ac10
Autor:
Helen Stutz, Anna-Lise Williamson, William R. Bourn, Paul D. van Helden, Yvette Jansen, Robin M. Warren
Publikováno v:
Tuberculosis. 87:481-488
The majority of mycobacterial plasmid vectors are derived from the pAL5000 replicon and maintained at approximately five copies per cell. We have devised a method that directly selects for high-copy-number plasmids. This involves enriching for high c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6aa3c675bcd12b3d1f789af12334c759
https://doi.org/10.1016/j.tube.2007.08.003
https://doi.org/10.1016/j.tube.2007.08.003
Autor:
Natalie M. Quanquin, Lydia Tesfa, Yongkai Mo, William R. Jacobs, Keith M. Derbyshire, William R. Bourn, Glenn J. Fennelly, Norman L. Letvin, William H. Vecino, Uma Devi K. Ranganathan
Publikováno v:
Infection and Immunity. 75:4804-4816
Mycobacteria target and persist within phagocytic monocytes and are strong adjuvants, making them attractive candidate vectors for DNA vaccines. We characterized the ability of mycobacteria to deliver transgenes to mammalian cells and the effects of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67d75e2effc2d6e775081974f26f6bbd
https://doi.org/10.1128/iai.01877-06
https://doi.org/10.1128/iai.01877-06
Autor:
Nyasha Chin'ombe, Enid G. Shephard, William R. Bourn, Ann E. Meyers, Anna-Lise Williamson, Thandi Mgwebi, Helen Stutz, Nicola Douglass, Rosamund Chapman
Publikováno v:
PLoS One
PLoS ONE, Vol 9, Iss 7, p e103314 (2014)
PLoS ONE
PLoS ONE, Vol 9, Iss 7, p e103314 (2014)
PLoS ONE
Numerous features make Mycobacterium bovis BCG an attractive vaccine vector for HIV. It has a good safety profile, it elicits long-lasting cellular immune responses and in addition manufacturing costs are affordable. Despite these advantages it is of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3406cb04d55d27658368d5934c99d12d
http://hdl.handle.net/11427/16227
http://hdl.handle.net/11427/16227
Autor:
James Maclean, Carolyn Williamson, Enid G. Shephard, Edward P. Rybicki, William R. Bourn, Ann E. Meyers, Gerald K. Chege, Robin Thomas, Clive M. Gray, Anna-Lise Williamson
Publikováno v:
Vaccine. 27(35)
Mycobacterium bovis BCG is considered an attractive live bacterial vaccine vector. In this study, we investigated the immune response of baboons to a primary vaccination with recombinant BCG (rBCG) constructs expressing the gag gene from a South Afri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cbdf1ff9d072d733a243ca21b54e8aa
https://pubmed.ncbi.nlm.nih.gov/19520196
https://pubmed.ncbi.nlm.nih.gov/19520196
Publikováno v:
Vaccine. 25(18)
Recombinant BCG expressing rotavirus VP6 was explored as an anti-rotavirus vaccine in a mouse model. Three promoters and five ribosome-binding sites were used in episomal and integrative E. coli-mycobacterium shuttle vectors to express VP6 in BCG. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f21ce83862a226ebb84d2ff1e9f99ea
https://pubmed.ncbi.nlm.nih.gov/17339069
https://pubmed.ncbi.nlm.nih.gov/17339069
Autor:
Craig D. Adams, Anna-Lise Williamson, Wendy A. Burgers, Thandiswa Mgwebi, Enid G. Shephard, Joanne van Harmelen, William R. Bourn, Tomáš Hanke, Carolyn Williamson
Publikováno v:
The Journal of general virology. 87(Pt 2)
In this study, the design and preclinical development of a multigene human immunodeficiency virus type 1 (HIV-1) subtype C DNA vaccine are described, developed as part of the South African AIDS Vaccine Initiative (SAAVI). Genetic variation remains a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dde4c3ca3a5c9106a0c9967cff2a28e9
https://pubmed.ncbi.nlm.nih.gov/16432028
https://pubmed.ncbi.nlm.nih.gov/16432028
Autor:
Anna-Lise Williamson, Bernhard Ryffel, Jo-Ann S. Passmore, Enid G. Shephard, William R. Bourn, Gerald K. Chege
Publikováno v:
Vaccine
Vaccine, Elsevier, 2005, 23, pp.5783-91
Vaccine, Elsevier, 2005, 23, pp.5783-91
Mycobacterium bovis Bacilli Calmette-Guerin (BCG) is used increasingly as an efficient vector for expression of recombinant proteins to induce a strong cell-mediated immunity. Here, we tested the immune response of Chacma baboons to the Tokyo and Pas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88986fb8f982868ad226775c7fb396f7
https://hal.archives-ouvertes.fr/hal-00094328
https://hal.archives-ouvertes.fr/hal-00094328
Autor:
R. Grundlingh, A. Harington, E G Hoal-van Helden, William R. Bourn, P. D. van Helden, Ian Wiid, Graeme Bradley
Publikováno v:
Tuberculosis (Edinburgh, Scotland). 82(2-3)
Setting : DNA repair genes assist the organism in maintaining DNA integrity in the face of environmental (mutagenic) stress. The genome sequences of M. tuberculosis and M. bovis demonstrate sequences suggestive of an O 6 -alkylguanine-DNA alkyltransf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::637370042341314231be761556a18890
https://pubmed.ncbi.nlm.nih.gov/12356454
https://pubmed.ncbi.nlm.nih.gov/12356454
Autor:
Robin M. Warren, Samantha L. Sampson, M. Richardson, H. Heersma, P. D. van Helden, William R. Bourn, G. D. van der Spuy, Winston Hide, Nulda Beyers, J. H. Hauman
Publikováno v:
ResearcherID
Setting: M. tuberculosis isolates were collected from patients attending health clinics in a high incidence urban community and in a low incidence rural setting in South Africa. Objective: To reconstruct the evolutionary history of a group of closely
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bbed170267e07b0f811b4667858c460
https://pubmed.ncbi.nlm.nih.gov/11584597
https://pubmed.ncbi.nlm.nih.gov/11584597