Zobrazeno 1 - 10
of 20
pro vyhledávání: '"William R. Bensch"'
Autor:
Yue-Wei Qian, Robert J. Schmidt, Youyan Zhang, Shaoyou Chu, Aimin Lin, He Wang, Xiliang Wang, Thomas P. Beyer, William R. Bensch, Weiming Li, Mariam E. Ehsani, Deshun Lu, Robert J. Konrad, Patrick I. Eacho, David E. Moller, Sotirios K. Karathanasis, Guoqing Cao
Publikováno v:
Journal of Lipid Research, Vol 48, Iss 7, Pp 1488-1498 (2007)
Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a protease that regulates low density lipoprotein receptor (LDLR) protein levels. The mechanisms of this action, however, remain to be defined. We show here that recombinant human PCSK9 express
Externí odkaz:
https://doaj.org/article/e83e1b4f8a864a4c80a2187d406a793c
Autor:
Aiming Lin, Yue-Wei Qian, Guoqing Cao, William R. Bensch, Robert J. Schmidt, Robert J. Konrad, Mark C. Kowala, William E. Alborn, Thomas P. Beyer
Publikováno v:
Biochemical and Biophysical Research Communications. 370:634-640
Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a serine protease that is known to reduce hepatic low-density lipoprotein receptor (LDLR) levels and increase plasma LDL cholesterol. It is not clear, however, whether secreted PCSK9 degrades e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e614c60c50aac2e758a8fdbc315e0090
https://doi.org/10.1016/j.bbrc.2008.04.004
https://doi.org/10.1016/j.bbrc.2008.04.004
Autor:
Shuyu Li, Tabetha M. Bonacci, Yang Zhao, Robert J. Konrad, David S. Bredt, William R. Bensch, Yan-Qun Chen, David E. Moller, Mark C. Kowala, Guoqing Cao
Publikováno v:
Journal of Biological Chemistry. 283:8258-8265
Phosphatidylcholine (PC) is synthesized through the Kennedy pathway, but more than 50% of PC is remodeled through the Lands cycle, i.e. the deacylation and reacylation of PC to attain the final and proper fatty acids within PC. The reacylation step i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c461684e037908f265846269d9f5b789
https://doi.org/10.1074/jbc.m710422200
https://doi.org/10.1074/jbc.m710422200
Autor:
James S. Bean, Nathan Bryan Mantlo, Pam McClelland, Raymond F. Kauffman, Guoming Wang, Jai Pal Singh, Chahrzad Montrose, Asavari Wagle, William R. Bensch
Publikováno v:
Molecular Pharmacology. 68:763-768
Low high-density lipoprotein-cholesterol (HDL-c) is an important risk factor of coronary artery disease (CAD). Optimum therapy for raising HDL-c is still not available. Identification of novel HDL-raising agents would produce a major impact on CAD. I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b644f836e10ddc2144b958c06092762
https://doi.org/10.1124/mol.105.010991
https://doi.org/10.1124/mol.105.010991
Autor:
Sha Liu, Raymond F. Kauffman, Garret J. Etgen, Dale E. Mais, Allie Edward Tripp, Chahrzad Montrose-Rafizadeh, Yanping Xu, Leonard L. Winneroski, Brian A. Oldham, Patric James Hahn, Deepa Rungta, Dawn A. Brooks, William R. Bensch, Mary K. Peters, Sarah B. Wilson, Kathy M Ogilvie, Mccarthy James R, Jacob R Bosley, Samuel J. Dominianni, Christopher John Rito, Richard W. Zink, Robert J. Ardecky, James S. Bean, Anthony J. Shuker, Carol L. Broderick, Gregory A. Stephenson
Publikováno v:
Journal of Medicinal Chemistry. 47:2422-2425
The design and synthesis of the dual peroxisome proliferator activated receptor (PPAR) alpha/gamma agonist (S)-2-methyl-3-[4-[2-(5-methyl-2-thiophen-2-yl-oxazol-4-yl)ethoxy]phenyl]-2-phenoxypropionic acid (2) for the treatment of type 2 diabetes and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1308bb3472bf950182ed5ac246acab95
https://doi.org/10.1021/jm0342616
https://doi.org/10.1021/jm0342616
Autor:
Patrick I. Eacho, Timothy P. Ryan, Jiannong Dai, Hong Gao, Sotirios K. Karathanasis, Xian-Cheng Jiang, Thomas P. Beyer, Raymond F. Kauffman, Youyan Zhang, Guoqing Cao, William R. Bensch, Patricia S. Foxworthy, Robert J. Schmidt
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 309:861-868
Liver X receptors (LXRs) are master transcription factors regulating cholesterol and fatty acid metabolism. Treatment of C57B6 mice with a specific synthetic LXR agonist, N-(2,2,2-trifluoroethyl)-N-[4-[2,2,2-trifluoro-1-hydroxy-1(trifluoromethyl)-eth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa5c46def2d8d6224963946702a3f2a8
https://doi.org/10.1124/jpet.103.064535
https://doi.org/10.1124/jpet.103.064535
Autor:
Youyan Zhang, Xian-Cheng Jiang, Robert J. Schmidt, William R. Bensch, Timothy P. Ryan, Guoqing Cao, Patrick I. Eacho, Yu Liang, Xiao Ping Yang, Hong Gao, Thomas P. Beyer, Raymond F. Kauffman
Publikováno v:
Journal of Biological Chemistry. 277:39561-39565
Liver X receptors (LXR) belong to the nuclear receptor superfamily that can regulate important lipid metabolic pathways. The plasma phospholipid transfer protein (PLTP) is known to mediate transfer of phospholipids from triglyceride-rich lipoproteins
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fa2a045d91b3330f08046c97f252f75
https://doi.org/10.1074/jbc.m207187200
https://doi.org/10.1074/jbc.m207187200
Autor:
James R. Paterniti, James M. Bilakovics, Mccarthy James R, William R. Bensch, Joseph T. Brozinick, Brian A. Oldham, Garret J. Etgen, Kathleen M. Ogilvie, Sha Liu, Christopher John Rito, Carol L. Broderick, Anthony J. Shuker, Robert J. Ardecky, James S. Bean, Elizabeth A. Misener, John S. Tyhonas, Sharon L. Dana, William T. Johnson, Dawn A. Brooks, Raymond F. Kauffman, Chahrzad R. Montrose
Publikováno v:
Diabetes. 51:1083-1087
A novel nonthiazolidinedione dual peroxisome proliferator- activated receptor (PPAR)-α/γ agonist, LY465608, was designed to address the major metabolic disturbances of type 2 diabetes. LY465608 altered PPAR-responsive genes in liver and fat of db/d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5b450b25eeadc156ea632676a20dd572
https://doi.org/10.2337/diabetes.51.4.1083
https://doi.org/10.2337/diabetes.51.4.1083
Autor:
Ashraff A. Rampersaud, Archer Ra, T F Bumol, Raymond F. Kauffman, L S Beavers, Ho-Shen Lin, Pawlak Jm, William R. Bensch, Schmidt Rj, L D Apelgren
Publikováno v:
Journal of Medicinal Chemistry. 38:277-288
A new series of sterols was synthesized and tested in a CHO cell-based LDL receptor/luciferase (LDLR/Luc) assay to investigate the capability of derepressing the transcription of LDL receptor promoter in the presence of 25-hydroxycholesterol. The eff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c91c7a660d1143ede3426f54cb972acc
https://doi.org/10.1021/jm00002a010
https://doi.org/10.1021/jm00002a010
Autor:
Weiming Li, Youyan Zhang, Mariam Ehsani, Deshun Lu, Robert J. Konrad, Xiliang Wang, David E. Moller, Thomas P. Beyer, Yue-Wei Qian, Shaoyou Chu, Guoqing Cao, Patrick I. Eacho, William R. Bensch, He Wang, Sotirios K. Karathanasis, Aimin Lin, Robert J. Schmidt
Publikováno v:
Journal of Lipid Research, Vol 48, Iss 7, Pp 1488-1498 (2007)
Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a protease that regulates low density lipoprotein receptor (LDLR) protein levels. The mechanisms of this action, however, remain to be defined. We show here that recombinant human PCSK9 express
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb7b06f3284ddffe7e5aca915a6e311f
https://pubmed.ncbi.nlm.nih.gov/17449864
https://pubmed.ncbi.nlm.nih.gov/17449864