Zobrazeno 1 - 10
of 59
pro vyhledávání: '"William R. A. Osborne"'
Autor:
Lihua Chen, Allison DeWispelaere, Frank Dastvan, William R A Osborne, Christine Blechner, Sabine Windhorst, Guenter Daum
Publikováno v:
PLoS ONE, Vol 11, Iss 5, p e0155726 (2016)
Smooth muscle alpha-actin (SMA) is a marker for the contractile, non-proliferative phenotype of adult smooth muscle cells (SMCs). Upon arterial injury, expression of SMA and other structural proteins decreases and SMCs acquire a pro-migratory and pro
Externí odkaz:
https://doaj.org/article/fc3ad2d2a80e43ef9de26e3323bf0076
Autor:
Ian R. Sweet, Benjamin J. Reed, Huiliang Zhang, Austin M. Rountree, Adam S. Neal, Kelly Kernan, William R. A. Osborne, Brian Van Yserloo, Wang Wang
Publikováno v:
Biochemical Journal. 473:4443-4456
A real-time method to measure intracellular hydrogen peroxide (H 2 O 2 ) would be very impactful in characterizing rapid changes that occur in physiologic and pathophysiologic states. Current methods do not provide the sensitivity, specificity and sp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1733a903ea26e917f9bd4a6678ee23c2
https://doi.org/10.1042/bcj20160481
https://doi.org/10.1042/bcj20160481
Autor:
Maria C. de Beer, Savitha Subramanian, Tomas Vaisar, Keith B. Elkon, Kevin D. O’Brien, Chang Yeop Han, Chongren Tang, Shari Wang, Myriam E. Guevara, Hao Wei, Tomasz Wietecha, Mohamed Omer, Frederick C. de Beer, Santica M. Marcovina, William R. A. Osborne, Alan Chait, Thomas N. Wight, Baohai Shao
Publikováno v:
Journal of Clinical Investigation. 126:266-281
HDL from healthy humans and lean mice inhibits palmitate-induced adipocyte inflammation; however, the effect of the inflammatory state on the functional properties of HDL on adipocytes is unknown. Here, we found that HDL from mice injected with AgNO3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3663867bf3074a4e4002edab4fa1b5d
https://doi.org/10.1172/jci83475
https://doi.org/10.1172/jci83475
Publikováno v:
Human Gene Therapy. 23:1136-1143
Cyclic neutropenia occurs in humans and gray collie dogs, is characterized by recurrent neutropenia, and is treated by repeated injections of recombinant granulocyte colony-stimulating factor (rG-CSF). As dose escalation of lentivirus may be clinical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6d6bec592ffedb2ae775b07dbaf277a
https://doi.org/10.1089/hum.2012.045
https://doi.org/10.1089/hum.2012.045
Autor:
Daniel H. Moralejo, William R. A. Osborne, Richard A. Jensen, Jessica M. Fuller, Anne E. Kwitek, Brian Van Yserloo, Ruth A. Ettinger, Åke Lernmark, Elizabeth A. Rutledge
Publikováno v:
Life Sciences; 89(19-20), pp 748-754 (2011)
Aims: The Gimap gene family has been shown to be integral to T cell survival and development. A frameshift mutation in Gimap5, one of seven members of the Gimap family, results in lymphopenia and is a prerequisite for spontaneous type 1 diabetes (T1D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b2f993d19d4ba9e70e03202a6331fc5
https://doi.org/10.1016/j.lfs.2011.08.016
https://doi.org/10.1016/j.lfs.2011.08.016
Autor:
Terry D. Tupling, Ofer Yanay, Åke Lernmark, Ian R. Sweet, Jessica M. Fuller, Merle L. Gilbert, Lanaya Waldron, William R. A. Osborne
Publikováno v:
Journal of Cellular and Molecular Medicine
Immunoprotection of islets using bioisolator systems permits introduction of allogeneic cells to diabetic patients without the need for immunosuppression. Using TheraCyte™ immunoisolation devices, we investigated two rat models of type 1 diabetes m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2869c0657d1ba5b2541fd7c99c928430
https://doi.org/10.1111/j.1582-4934.2008.00322.x
https://doi.org/10.1111/j.1582-4934.2008.00322.x
Publikováno v:
The Journal of Gene Medicine. 9:571-578
Towards gene therapy treatment of patients with neutropenia, characterized by neutrophil counts500 cells/microl, we investigated the ability of lentivirus vectors to provide sustained granulocyte colony-stimulating factor (G-CSF) delivery and to perm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09e9f58eb61ea6f73dee5f9046fd1da1
https://doi.org/10.1002/jgm.1050
https://doi.org/10.1002/jgm.1050
Autor:
Sabine Windhorst, Allison DeWispelaere, Christine Blechner, Frank Dastvan, William R. A. Osborne, Guenter Daum, Lihua Chen
Publikováno v:
PLoS ONE
PLoS ONE, Vol 11, Iss 5, p e0155726 (2016)
PLoS ONE, Vol 11, Iss 5, p e0155726 (2016)
Smooth muscle alpha-actin (SMA) is a marker for the contractile, non-proliferative phenotype of adult smooth muscle cells (SMCs). Upon arterial injury, expression of SMA and other structural proteins decreases and SMCs acquire a pro-migratory and pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1416da2ded414e204dc63ce9d533598
https://pubmed.ncbi.nlm.nih.gov/27176050
https://pubmed.ncbi.nlm.nih.gov/27176050
Publikováno v:
Journal of Inflammation Research
Ofer Yanay,1,2 Adam L Bailey,3 Kelly Kernan,1 Jerry J Zimmerman,1,2 William R Osborne1 1Department of Pediatrics, University of Washington, 2Division of Pediatric Critical Care Medicine, Seattle Children's Hospital, Seattle, WA, 3Medical Scientist Tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::946525ead142f7ea789d400cb9363b60
https://www.dovepress.com/effects-of-exendin-4-a-glucagon-like-peptide-1-receptor-agonist-on-neu-peer-reviewed-article-JIR
https://www.dovepress.com/effects-of-exendin-4-a-glucagon-like-peptide-1-receptor-agonist-on-neu-peer-reviewed-article-JIR
Autor:
Simon C. Barry, Ofer Yanay, William R. A. Osborne, Lisa Y. Flint, Randall W. Barton, Margaret Brzezinski
Publikováno v:
Human Gene Therapy. 14:1587-1593
Recombinant erythropoietin (EPO) is widely administered for long-term treatment of anemia associated with renal failure and other chronic diseases. The ability to deliver EPO by gene therapy would have clinical and economic benefit. We compared autol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::406049b8bbe8c7cf4ff70ba7def63494
https://doi.org/10.1089/104303403322542239
https://doi.org/10.1089/104303403322542239