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pro vyhledávání: '"William R Solvibile"'
Publikováno v:
Tetrahedron. 59:3183-3188
The aglycone of 26-O-deacetyl pavoninin-5, (25R)-cholest-5-en-3β,15α,26-triol, 5a , was synthesized in 10 steps in 17% overall yield from diosgenin, 3 . Removing mercury from the Clemmensen reduction of diosgenin 3 , gave a higher yield of (25R)-ch
Autor:
Robert J. Steffan, Mark A. Ashwell, William R. Solvibile, Edward Matelan, Elwood Largis, Stella Han, Jeffery Tillet, Ruth Mulvey
Publikováno v:
Bioorganicmedicinal chemistry letters. 12(20)
The synthesis and SAR of a series of human beta3 adrenoreceptor agonists based on a template derived from a common pharmacophore coupled with 4-aminomethylpiperidine is described. Potent and selective agents were identified such as 26 that was in vit