Zobrazeno 1 - 10
of 12
pro vyhledávání: '"William R Jacobs Jr"'
Autor:
Welkin H Pope, Charles A Bowman, Daniel A Russell, Deborah Jacobs-Sera, David J Asai, Steven G Cresawn, William R Jacobs Jr, Roger W Hendrix, Jeffrey G Lawrence, Graham F Hatfull, Science Education Alliance Phage Hunters Advancing Genomics and Evolutionary Science, Phage Hunters Integrating Research and Education, Mycobacterial Genetics Course
Publikováno v:
eLife, Vol 4 (2015)
The bacteriophage population is large, dynamic, ancient, and genetically diverse. Limited genomic information shows that phage genomes are mosaic, and the genetic architecture of phage populations remains ill-defined. To understand the population str
Externí odkaz:
https://doaj.org/article/3bc1b58b6d124a06a5de0dee6ee7b7f3
Autor:
Christopher Petro, Pablo A González, Natalia Cheshenko, Thomas Jandl, Nazanin Khajoueinejad, Angèle Bénard, Mayami Sengupta, Betsy C Herold, William R Jacobs Jr
Publikováno v:
eLife, Vol 4 (2015)
Subunit vaccines comprised of glycoprotein D (gD-2) failed to prevent HSV-2 highlighting need for novel strategies. To test the hypothesis that deletion of gD-2 unmasks protective antigens, we evaluated the efficacy and safety of an HSV-2 virus delet
Externí odkaz:
https://doaj.org/article/beb874f5e9584b4bb6fcff4c07eebbf6
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 19 (2023)
First achieved in 1998 by Cole et al., the complete genome sequence of Mycobacterium tuberculosis continues to provide an invaluable resource to understand tuberculosis (TB), the leading cause of global infectious disease mortality. At the 25-year an
Externí odkaz:
https://doaj.org/article/5b86af80b7844a519e94f7b350324bc6
Autor:
William R. Jacobs Jr.
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 18 (2022)
Tuberculosis (TB), caused by Mycobacterium tuberculosis infection, remains a leading cause of death from an infectious agent, resulting in more than a million deaths per year. Despite vaccines and chemotherapies, patients often harbor persister M. tu
Externí odkaz:
https://doaj.org/article/23ae0f1dee614db78cab2741292bdeae
Autor:
Pooja Gupta, Sherine E. Thomas, Shaymaa A. Zaidan, Maria A. Pasillas, James Cory-Wright, Víctor Sebastián-Pérez, Ailidh Burgess, Emma Cattermole, Clio Meghir, Chris Abell, Anthony G. Coyne, William R. Jacobs, Jr., Tom L. Blundell, Sangeeta Tiwari, Vítor Mendes
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 19, Iss , Pp 3491-3506 (2021)
The L-arginine biosynthesis pathway consists of eight enzymes that catalyse the conversion of L-glutamate to L-arginine. Arginine auxotrophs (argB/argF deletion mutants) of Mycobacterium tuberculosis are rapidly sterilised in mice, while inhibition o
Externí odkaz:
https://doaj.org/article/0589d4fe9fbe444192900ca3afd6da59
Autor:
Estalina Báez-Ramírez, Luis Querales, Carlos Andres Aranaga, Gustavo López, Elba Guerrero, Laurent Kremer, Séverine Carrère-Kremer, Albertus Viljoen, Mamadou Daffé, Françoise Laval, Stewart T. Cole, Andrej Benjak, Pedro Alzari, Gwenaëlle André-Leroux, William R. Jacobs, Jr., Catherine Vilcheze, Howard E. Takiff
Publikováno v:
The Cell Surface, Vol 7, Iss , Pp 100060- (2021)
Four serine/threonine kinases are present in all mycobacteria: PknA, PknB, PknG and PknL. PknA and PknB are essential for growth and replication, PknG regulates metabolism, but little is known about PknL. Inactivation of pknL and adjacent regulator M
Externí odkaz:
https://doaj.org/article/611ee645f9a642f8b53d9cbe636b8cf3
Can today's innovative practices and molecular tools tame this ancient disease? One third of the world's population is infected with tuberculosis (TB), with about 10 million new cases annually. To combat TB and its agent, Mycobacterium tuberculosis,
A comprehensive collection of perspectives by experts in mycobacterial molecular biology Mycobacterium tuberculosis causes one in four avoidable deaths in the developing world and kills more adults than malaria, AIDS, and all tropical diseases combin
Autor:
Charles C Scherer, Janice J Endsley, Juliana deAguiar, William R Jacobs Jr., Michelle H Larsen, Mitchell V Palmer, Brian J Nonnecke, William T Golde, W Ray Waters, D Mark Estes
Publikováno v:
The Journal of Immunology. 182:81.10-81.10
Development of improved vaccines against tuberculosis (TB) is directly correlated to the investigation of new and better correlates of protection after vaccination. We examined the kinetics of granulysin, perforin, IFN-gamma and Fas-L responses to M.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::636e70f00cc7cdfc9f78785dc4a617a2
https://doi.org/10.4049/jimmunol.182.supp.81.10
https://doi.org/10.4049/jimmunol.182.supp.81.10
Autor:
William R. Jacobs, Jr.,‡,§, John S. Blanchard, Andréa Dessen, Annaik Quemard, Michelle Sugantino, and James C. Sacchettini
Publikováno v:
Journal of the American Chemical Society. 118:1561-1562
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6c0fddb78be3e7bd7665aa70e7b1c371
https://doi.org/10.1021/ja950998b
https://doi.org/10.1021/ja950998b