Zobrazeno 1 - 10
of 93
pro vyhledávání: '"William R Crum"'
Autor:
Michel Modo, William R Crum, Madeline Gerwig, Anthony C Vernon, Priya Patel, Michael J Jackson, Sarah Rose, Peter Jenner, Mahmoud M Iravani
Publikováno v:
PLoS ONE, Vol 12, Iss 7, p e0180733 (2017)
Parkinson's disease (PD) is the second most common neurodegenerative disorder producing a variety of motor and cognitive deficits with the causes remaining largely unknown. The gradual loss of the nigrostriatal pathway is currently considered the piv
Externí odkaz:
https://doaj.org/article/91148428799c41da9497d54eaabb1f5a
Autor:
Ivan Rattray, Edward J Smith, William R Crum, Thomas A Walker, Richard Gale, Gillian P Bates, Michel Modo
Publikováno v:
PLoS ONE, Vol 12, Iss 1, p e0168556 (2017)
A variety of mouse models have been developed that express mutant huntingtin (mHTT) leading to aggregates and inclusions that model the molecular pathology observed in Huntington's disease. Here we show that although homozygous HdhQ150 knock-in mice
Externí odkaz:
https://doaj.org/article/02a1eb9f87a24ff0bf3fe0e6e3785ecf
Autor:
Ivana Rosenzweig, Matthew J Kempton, William R Crum, Martin Glasser, Milan Milosevic, Sandor Beniczky, Douglas R Corfield, Steven C Williams, Mary J Morrell
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e83173 (2013)
The full impact of multisystem disease such as obstructive sleep apnoea (OSA) on regions of the central nervous system is debated, as the subsequent neurocognitive sequelae are unclear. Several preclinical studies suggest that its purported major cul
Externí odkaz:
https://doaj.org/article/b6a5bc63229d446f8288743bcadc1aba
Autor:
Ivan Rattray, Edward J Smith, William R Crum, Thomas A Walker, Richard Gale, Gillian P Bates, Michel Modo
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e84726 (2013)
Huntington's disease (HD) is caused by the expansion of a CAG repeat in the huntingtin (HTT) gene. The R6 mouse models of HD express a mutant version of exon 1 HTT and typically develop motor and cognitive impairments, a widespread huntingtin (HTT) a
Externí odkaz:
https://doaj.org/article/9aef2a1430684f44b41840a660bd8f54
Publikováno v:
PLoS ONE, Vol 6, Iss 2, p e17269 (2011)
Establishing the neurological basis of behavioural dysfunction is key to provide a better understanding of Parkinson's disease (PD) and facilitate development of effective novel therapies. For this, the relationships between longitudinal structural b
Externí odkaz:
https://doaj.org/article/6e8f3b54cb0d4d0797892facafc65426
Autor:
Marianna, Inglese, Neva, Patel, Kristofer, Linton-Reid, Flavia, Loreto, Zarni, Win, Richard J, Perry, Christopher, Carswell, Matthew, Grech-Sollars, William R, Crum, Haonan, Lu, Paresh A, Malhotra, Gail, Li
Alzheimer's disease, the most common cause of dementia, causes a progressive and irreversible deterioration of cognition that can sometimes be difficult to diagnose, leading to suboptimal patient care.We developed a predictive model that computes mul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67aff9a1a3ef401d67561c90b2cfb339
http://hdl.handle.net/10044/1/97726
http://hdl.handle.net/10044/1/97726
Autor:
Rohini Sharma, Haonan Lu, Paul D Tait, Neva H. Patel, Chandan Sanghera, William R. Crum, David J. Pinato, Suraiya Dubash, Eric O. Aboagye, Tara Barwick, Anthony Jen-Yu Chung, Marianna Inglese, Francesco Mauri
Publikováno v:
Journal of Nuclear Medicine. 61:1743-1748
Accurate disease monitoring is essential following transarterial chemoembolization (TACE) in hepatocellular carcinoma (HCC) due to potential for profound adverse event and large variation in survival outcome. Post-treatment changes on conventional im
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7781ff22c88fcfe078f44de62f653875
https://doi.org/10.2967/jnumed.119.240598
https://doi.org/10.2967/jnumed.119.240598
Autor:
Christina Fotopoulou, Andrea Rockall, Haonan Lu, Philippa Lee, Giacomo Avesani, Luca Russo, Federica Petta, Beyhan Ataseven, Kai-Uwe Waltering, Jens Albrecht Koch, William R. Crum, Paula Cunnea, Florian Heitz, Philipp Harter, Eric O. Aboagye, Andreas du Bois, Sonia Prader
Publikováno v:
British journal of cancer. 126(7)
Background Predictive models based on radiomics features are novel, highly promising approaches for gynaecological oncology. Here, we wish to assess the prognostic value of the newly discovered Radiomic Prognostic Vector (RPV) in an independent cohor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ade50dece925f9fdc9573f4cd94828cd
https://pubmed.ncbi.nlm.nih.gov/34923575
https://pubmed.ncbi.nlm.nih.gov/34923575
Autor:
Rohini, Sharma, Marianna, Inglese, Suraiya, Dubash, Haonan, Lu, David J, Pinato, Chandan, Sanghera, Neva, Patel, Anthony, Chung, Paul D, Tait, Francesco, Mauri, William R, Crum, Tara D, Barwick, Eric O, Aboagye
Publikováno v:
Journal of Nuclear Medicine
Accurate disease monitoring is essential after transarterial chemoembolization (TACE) in hepatocellular carcinoma (HCC) because of the potential for profound adverse events and large variations in survival outcome. Posttreatment changes on convention
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cdc14a1d03b5ca7c30f98dabb4694d32
https://pubmed.ncbi.nlm.nih.gov/32513905
https://pubmed.ncbi.nlm.nih.gov/32513905
Autor:
Johannes Streffer, Danai Dima, Anna J.E. Combes, Amanda Worker, Gareth J. Barker, Steven Einstein, William R. Crum, Owen O'Daly, Steven Williams, Mitul A. Mehta
Publikováno v:
Hum Brain Mapp
Worker, A, Dima, D, Combes, A, Crum, W R, Streffer, J, Einstein, S, Mehta, M A, Barker, G J, Williams, S C R & O'Daly, O 2018, ' Test-retest reliability and longitudinal analysis of automated hippocampal subregion volumes in healthy ageing and Alzheimer’s disease populations ', Human Brain Mapping . https://doi.org/10.1002/hbm.23948, https://doi.org/10.1002/hbm.23948
Worker, A, Dima, D, Combes, A, Crum, W R, Streffer, J, Einstein, S, Mehta, M A, Barker, G J, Williams, S C R & O'Daly, O 2018, ' Test-retest reliability and longitudinal analysis of automated hippocampal subregion volumes in healthy ageing and Alzheimer’s disease populations ', Human Brain Mapping . https://doi.org/10.1002/hbm.23948, https://doi.org/10.1002/hbm.23948
The hippocampal formation is a complex brain structure that is important in cognitive processes such as memory, mood, reward processing and other executive functions. Histological and neuroimaging studies have implicated the hippocampal region in neu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77731ca6f52f728b92726a57047907e2
https://europepmc.org/articles/PMC6866454/
https://europepmc.org/articles/PMC6866454/