Zobrazeno 1 - 10
of 84
pro vyhledávání: '"William R Cannon"'
Autor:
William R Cannon
Publikováno v:
PLoS ONE, Vol 9, Iss 8, p e103582 (2014)
New methods are needed for large scale modeling of metabolism that predict metabolite levels and characterize the thermodynamics of individual reactions and pathways. Current approaches use either kinetic simulations, which are difficult to extend to
Externí odkaz:
https://doaj.org/article/b4d724c584c84659bf6e80becccb3d30
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract High performance computing has a great potential to provide a range of significant benefits for investigating biological systems. These systems often present large modelling problems with many coupled subsystems, such as when studying coloni
Externí odkaz:
https://doaj.org/article/a59004e3ece349299bc016c6c012678d
Publikováno v:
Frontiers in Systems Biology, Vol 3 (2023)
Elucidating cell regulation remains a challenging task due to the complexity of metabolism and the difficulty of experimental measurements. Here we present a method for prediction of cell regulation to maximize cell growth rate while maintaining the
Externí odkaz:
https://doaj.org/article/4cd7064f4bd74b86b26a51252d1be63d
Autor:
Lionel M. Raff, William R. Cannon
Publikováno v:
Physical chemistry chemical physics : PCCP. 23(27)
In 1994, an IUBMB–IUPAC joint committee recommended a revised formulation for standard chemical potentials and reaction free energies motivated by the fact that, in biochemistry, the reactants and products often exist in multiple charge states depe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::493bc60f3e2c33a5de3260a77a2b08fe
https://pubmed.ncbi.nlm.nih.gov/34196644
https://pubmed.ncbi.nlm.nih.gov/34196644
Autor:
Adrian Buganza Tepole, William W. Lytton, Linda R. Petzold, William R. Cannon, Salvador Dura-Bernal, Ellen Kuhl, Mark Alber, George Em Karniadakis, Krishna Garikipati, Suvranu De, Paris Perdikaris
Publikováno v:
npj Digital Medicine, Vol 2, Iss 1, Pp 1-11 (2019)
NPJ digital medicine, vol 2, iss 1
NPJ Digital Medicine
NPJ digital medicine, vol 2, iss 1
NPJ Digital Medicine
Fueled by breakthrough technology developments, the biological, biomedical, and behavioral sciences are now collecting more data than ever before. There is a critical need for time- and cost-efficient strategies to analyze and interpret these data to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85abd7dba255e2137deb9e02c4b552c9
http://link.springer.com/article/10.1038/s41746-019-0193-y
http://link.springer.com/article/10.1038/s41746-019-0193-y
Autor:
Lionel M. Raff, William R. Cannon
Publikováno v:
Journal of Chemical Education. 96:274-284
For 26 years, it has been assumed by some that the thermodynamics of open-system biochemical reactions must be executed by performing Legendre transformations on the terms involving the species whose concentrations are being held fixed. In contrast,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f26a5202bf976fee2d5f8599dddf82af
https://doi.org/10.1021/acs.jchemed.8b00795
https://doi.org/10.1021/acs.jchemed.8b00795
Publikováno v:
Proceedings of Entropy 2021: The Scientific Tool of the 21st Century.
Experimental measurement or computational inference/prediction of the enzyme regulation needed in a metabolic pathway is hard problem. Consequently, regulation is known only for well-studied reactions of central metabolism in a few organisms. In this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::63b6e042811c9b94dd0e97400f049ec1
https://doi.org/10.3390/entropy2021-09867
https://doi.org/10.3390/entropy2021-09867
Publikováno v:
Journal of the Royal Society, Interface, vol 17, iss 171
Journal of the Royal Society Interface
Journal of the Royal Society Interface
Experimental measurements or computational model predictions of the post-translational regulation of enzymes needed in a metabolic pathway is a difficult problem. Consequently, regulation is mostly known only for well-studied reactions of central met
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::927339d1d7ed62716bfbdab388617105
https://escholarship.org/uc/item/2k236090
https://escholarship.org/uc/item/2k236090
Experimental measurements or computational model predictions of the post-translational regulation of enzymes needed in a metabolic pathway is a difficult problem. Consequently, regulation is mostly known only for well-studied reactions of central met
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::209198e32b78525cf1528040b958026d
https://doi.org/10.1101/2020.04.06.028035
https://doi.org/10.1101/2020.04.06.028035
Autor:
Srividya Murali, William R. Cannon, Guanqi Zhao, Robert L. Hettich, Justin A. North, John A. Wildenthal, Weili Xiong, Kelly C. Wrighton, Kathryn M. Byerly, Sarah J. Young, Adrienne B. Narrowe, F. Robert Tabita
Publikováno v:
Science (New York, N.Y.). 369(6507)
Soil sulfur metabolism surprise Soil bacteria have a range of metabolic pathways that contribute to acquiring and recycling nutrients and carbon. Curiously, some of these organisms give off ethylene gas when starved for sulfur under anaerobic conditi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4aa3dabf75ad33b066329a552067fa92
https://pubmed.ncbi.nlm.nih.gov/32855335
https://pubmed.ncbi.nlm.nih.gov/32855335