Zobrazeno 1 - 10
of 70
pro vyhledávání: '"William R, Wolter"'
Autor:
Bette S. Pollard, Mark. A. Suckow, William R. Wolter, Joshua M. Starr, Ofer Eidelman, Clifton L. Dalgard, Parameet Kumar, Sharmistha Battacharyya, Meera Srivastava, Roopa Biswas, Matthew D. Wilkerson, Xijun Zhang, Qingfeng Yang, Harvey B. Pollard
Publikováno v:
Frontiers in Oncology, Vol 9 (2019)
Castration Resistant Prostate Cancer (CRPC) is thought to be driven by a collaborative mechanism between TNFα/NFκB and TGFβ signaling, leading to inflammation, Epithelial-to-Mesenchymal-Transition (EMT), and metastasis. Initially, TGFβ is a tumor
Externí odkaz:
https://doaj.org/article/835f8a6f1f46486a86a13beb23b54efd
Autor:
Jeshina Janardhanan, Choon Kim, Yuanyuan Qian, Jingdong Yang, Jayda E. Meisel, Derong Ding, Enrico Speri, Valerie A. Schroeder, William R. Wolter, Allen G. Oliver, Shahriar Mobashery, Mayland Chang
Publikováno v:
Proceedings of the National Academy of Sciences. 120
Clostridioides difficile infection (CDI) is the most lethal of the five CDC urgent public health treats, resulting in 12,800 annual deaths in the United States alone [ Antibiotic Resistance Threats in the United States, 2019 (2019), www.cdc.gov/DrugR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5315e7eae115be15f759b068aa19d109
https://doi.org/10.1073/pnas.2304110120
https://doi.org/10.1073/pnas.2304110120
Autor:
Mayland Chang, Enrico Speri, Valerie A. Schroeder, Elena Lastochkin, Cesar Masitas, Jeshina Janardhanan, Shahriar Mobashery, William R. Wolter, Jed F. Fisher
Publikováno v:
ACS Infectious Diseases. 6:2362-2368
A major challenge for chemotherapy of bacterial infections is perturbation of the intestinal microbiota. Clostridioides difficile is a Gram-positive bacterium of the gut that can thrive under this circumstance. Its production of dormant and antibioti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a7f01523b20a6443800c50dd14abd7bf
https://doi.org/10.1021/acsinfecdis.0c00479
https://doi.org/10.1021/acsinfecdis.0c00479
Autor:
Kiran V. Mahasenan, Jeshina Janardhanan, Sara Tejera, Elena Lastochkin, Shahriar Mobashery, Yuanyuan Qian, William R. Wolter, Giuseppe Allegretta, Zhihong Peng, Melissa Malia N. Gozun, Mayland Chang, Rhona Feltzer, Valerie A. Schroeder
Publikováno v:
Journal of Medicinal Chemistry. 63:5287-5296
We report herein the syntheses of 79 derivatives of the 4(3H)-quinazolinones and their structure-activity relationship (SAR) against methicillin-resistant Staphylococcus aureus (MRSA). Twenty one analogs were further evaluated in in vitro assays. Sub
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6291ab9052c87a4a8a8d6f64b0fe64be
https://doi.org/10.1021/acs.jmedchem.0c00153
https://doi.org/10.1021/acs.jmedchem.0c00153
Autor:
Trung T. Nguyen, Mayland Chang, Ming Gao, Valerie A. Schroeder, Bowen Anderson, William R. Wolter, Mark A. Suckow, Major Gooyit
Publikováno v:
ACS Pharmacol Transl Sci
[Image: see text] Matrix metalloproteinases (MMPs) play important roles in wound healing, but attribution of their functions in repair of wounds has been challenging. Commonly used tools such as MMP-knockout mice and zymography often confound analysi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f03c4b6ac6af8502d7ec779d1b675100
https://doi.org/10.1021/acsptsci.9b00109
https://doi.org/10.1021/acsptsci.9b00109
Autor:
Mayland Chang, Enrico Speri, Allen G. Oliver, Elena Lastochkin, Man Wang, Jed F. Fisher, Jeshina Janardhanan, Stefania De Benedetti, Yuanyuan Qian, Shahriar Mobashery, Cesar Masitas, Valerie A. Schroeder, William R. Wolter
Publikováno v:
ACS Med Chem Lett
[Image: see text] Clostridioides difficile is a leading health threat. This pathogen initiates intestinal infections during gut microbiota dysbiosis caused by oral administration of antibiotics. C. difficile is difficult to eradicate due to its abili
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55082532619fb3ef047df3b2e1cb42df
https://europepmc.org/articles/PMC8201750/
https://europepmc.org/articles/PMC8201750/
Autor:
Enrico, Speri, Jeshina, Janardhanan, Cesar, Masitas, Valerie A, Schroeder, Elena, Lastochkin, William R, Wolter, Jed F, Fisher, Shahriar, Mobashery, Mayland, Chang
Publikováno v:
ACS Infect Dis
A major challenge for chemotherapy of bacterial infections is perturbation of the intestinal microbiota. Clostridioides difficile is a Gram-positive bacterium of the gut that can thrive under this circumstance. Its production of dormant and antibioti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ec0ebab81942731f766dd2a3920ed7cd
https://pubmed.ncbi.nlm.nih.gov/32786277
https://pubmed.ncbi.nlm.nih.gov/32786277
Autor:
Zhihong, Peng, Trung T, Nguyen, Wei, Song, Bowen, Anderson, William R, Wolter, Valerie A, Schroeder, Dusan, Hesek, Mijoon, Lee, Shahriar, Mobashery, Mayland, Chang
Publikováno v:
ACS Pharmacol Transl Sci
[Image: see text] Diabetic foot ulcers (DFUs) are a common complication of diabetes that are recalcitrant to healing due to persistent inflammation. The majority of DFUs have bacterial biofilms, with Staphylococcus epidermidis as a predominant bacter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8f138650725d3398d08d6bad356d6bfa
https://pubmed.ncbi.nlm.nih.gov/33615165
https://pubmed.ncbi.nlm.nih.gov/33615165
Autor:
Yuanyuan, Qian, Giuseppe, Allegretta, Jeshina, Janardhanan, Zhihong, Peng, Kiran V, Mahasenan, Elena, Lastochkin, Melissa Malia N, Gozun, Sara, Tejera, Valerie A, Schroeder, William R, Wolter, Rhona, Feltzer, Shahriar, Mobashery, Mayland, Chang
Publikováno v:
J Med Chem
We report herein the syntheses of 79 derivatives of the 4(3H)-quinazolinones and their structure–activity relationship (SAR) against methicillin-resistant Staphylococcus aureus (MRSA). Twenty one analogs were further evaluated in in vitro assays. S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::152bc927bf3a7db1e25ac82eece1fd30
https://pubmed.ncbi.nlm.nih.gov/32343145
https://pubmed.ncbi.nlm.nih.gov/32343145
Autor:
Matthew M. Champion, Dusan Hesek, Trung T. Nguyen, Rocio L. Pérez, Valerie A. Schroeder, Mark A. Suckow, Mijoon Lee, Shahriar Mobashery, William R. Wolter, Derong Ding, Mayland Chang
Publikováno v:
European Journal of Pharmacology. 834:77-83
Chronic wounds are a complication of diabetes. Treatment for diabetic foot ulcers is complex with little clinical recourse, resulting in 108,000 lower-limb amputations annually in the United States alone. Matrix metalloproteinases (MMPs) play importa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3c4978b2adec3d38d97a0867b1738c7
https://doi.org/10.1016/j.ejphar.2018.07.014
https://doi.org/10.1016/j.ejphar.2018.07.014