Zobrazeno 1 - 10
of 71
pro vyhledávání: '"William R, Ewing"'
Autor:
Jeffrey M. Bozarth, Pancras C. Wong, Earl J. Crain, William R. Ewing, Joseph M. Luettgen, David A. Gordon, Ruth R. Wexler, Yiming Wu, Dilger Andrew K
Publikováno v:
Journal of Thrombosis and Haemostasis. 20:399-408
BACKGROUND Milvexian (BMS-986177/JNJ-70033093) is an orally bioavailable factor XIa (FXIa) inhibitor currently in phase 2 clinical trials. OBJECTIVES To evaluate in vitro properties and in vivo characteristics of milvexian. METHODS In vitro propertie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1676afb5bd0ef4a349d5e7addf749e89
https://doi.org/10.1111/jth.15588
https://doi.org/10.1111/jth.15588
Autor:
Jennifer X. Qiao, Steven Bloom, William R. Ewing, Daniel G. Oblinsky, Gregory D. Scholes, Richard Y.-C. Huang, Daniel K. Kim, Beryl X. Li, David W. C. MacMillan
Publikováno v:
Nature Chemistry. 13:902-908
The growing prevalence of synthetically modified proteins in pharmaceuticals and materials has exposed the need for efficient strategies to enable chemical modifications with high site-selectivity. While genetic engineering can incorporate non-natura
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6f126eb2baf200e603122655e4d146ad
https://doi.org/10.1038/s41557-021-00733-y
https://doi.org/10.1038/s41557-021-00733-y
Autor:
Kap-Sun Yeung, William R. Ewing, Jin-Quan Yu, Zhen Li, Shaoqun Qian, Nikita Chekshin, Zhen Wang, Jennifer X. Qiao, Peter T. W. Cheng
Publikováno v:
Science
Easing oxygen into arenes Although oxygen is all around us, it is often surprisingly difficult to use it for selective chemical oxidations, necessitating more expensive, wasteful alternatives. Li et al. report that careful ligand optimization produce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::caa3a3696a054fe406c7b78a9e81cb4a
https://doi.org/10.1126/science.abg2362
https://doi.org/10.1126/science.abg2362
Publikováno v:
Angew Chem Int Ed Engl
Fluorine is known to promote ortho-C-H metalation. Based upon this reactivity, we employed an activated norbornene that traps the ortho-palladation intermediate and is then relayed to the meta position, leading to meta-selective C-H arylation of fluo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13aa156d9c01d651b422480b6f8f51fe
https://doi.org/10.1002/ange.202002865
https://doi.org/10.1002/ange.202002865
Autor:
Arunachalam Arumugam, Dietmar A. Seiffert, Arvind Mathur, Joanna J. Zheng, Ruth R. Wexler, Jeon Yoon T, Premsai Rai Neithnadka, Earl J. Crain, Paul J. Gilligan, Patrick Y.S. Lam, Yiming Wu, Mahammed Kaspady, Pancras C. Wong, Tianan Fang, Silvi A. Chacko, William R. Ewing, Pabbisetty Kumar Balashanmuga, Zhen Lou, Steven Sheriff, Joseph M. Luettgen, Joseph E. Myers, Wu Yang, Karen A. Rossi, Richard Rampulla, James R. Corte, Amy Lai, Charles G. Clark, Jeffrey M. Bozarth, Yufeng Wang, Sivashankaran Raju
Publikováno v:
Journal of Medicinal Chemistry. 63:7226-7242
Oral factor XIa (FXIa) inhibitors may provide a promising new antithrombotic therapy with an improved benefit to bleeding risk profile over existing antithrombotic agents. Herein, we report application of a previously disclosed cyclic carbamate P1 li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58ab508367fcb2f182343eb9240eeb1b
https://doi.org/10.1021/acs.jmedchem.0c00464
https://doi.org/10.1021/acs.jmedchem.0c00464
Autor:
David J. Donnelly, Eric W. Webb, Erin L. Cole, William R. Ewing, Samuel J. Bonacorsi, Abigail G. Doyle, John B. Park
Publikováno v:
Journal of the American Chemical Society. 142:9493-9500
We report a redox-neutral method for nucleophilic fluorination of N-hydroxyphthalimide esters using an Ir photocatalyst under visible light irradiation. The method provides access to a broad range of aliphatic fluorides, including primary, secondary,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::986fad4cf8e0261fa22a7649c4db7c47
https://doi.org/10.1021/jacs.0c03125
https://doi.org/10.1021/jacs.0c03125
Autor:
Minyan Li, Jennifer X. Qiao, Jason S. Chen, Jin-Quan Yu, Jeremy M. Richter, Martin D. Eastgate, Shaoqun Qian, William R. Ewing, Zi-Qi Li, Steven R. Wisniewski
Publikováno v:
Organic Letters. 22:3960-3963
Pd(II)-catalyzed C-H lactonization of o-methyl benzoic acid substrates has been achieved using molecular oxygen as the oxidant. This finding provides a rare example of C-H oxygenation through Pd(II)/Pd(0) catalysis as well as a method to construct bi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::38799de0c7c216e28fdfda9b0bc79676
https://doi.org/10.1021/acs.orglett.0c01243
https://doi.org/10.1021/acs.orglett.0c01243
Publikováno v:
Angewandte Chemie International Edition. 59:9594-9600
The use of chiral transient directing groups (TDGs) is a promising approach for developing PdII -catalyzed enantioselective C(sp3 )-H activation reactions. However, this strategy is challenging because the stereogenic center on the TDG is often far f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bc863587f0e7bbac228adc80c08006e
https://doi.org/10.1002/anie.202000532
https://doi.org/10.1002/anie.202000532
Autor:
Shuang Liu, Zhe Zhuang, Jennifer X. Qiao, Kap-Sun Yeung, Shun Su, Emily C. Cherney, Zheming Ruan, William R. Ewing, Michael A. Poss, Jin-Quan Yu
Publikováno v:
J Am Chem Soc
γ-Lactams form important structural cores of a range of medicinally-relevant natural products and clinical drugs, principal examples being the new generation of immunomodulatory imide drugs (IMiDs) and the brivaracetam family. Compared to convention
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6e435084c43e9a77b57719fbe46530c
https://europepmc.org/articles/PMC9116424/
https://europepmc.org/articles/PMC9116424/
Autor:
Jacques Y. Roberge, Guixue Yu, Amarendra Mikkilineni, Ximao Wu, Yeheng Zhu, R. Michael Lawrence, William R. Ewing
Publikováno v:
ARKIVOC, Vol 2007, Iss 12, Pp 132-147 (2007)
Externí odkaz:
https://doaj.org/article/354d14f1bfc542a0ac1e7157fd9b7867